Issue 8, 2016

Angiotensin II analogs comprised of Pro-Amb (γ-turn scaffold) as angiotensin II type 2 (AT2) receptor agonists

Abstract

We describe herein the design, synthesis and conformational investigation of Pro-Amb (proline-3-amino-2-methoxybenzoic acid) incorporated Angiotensin II and its truncated analogues. Solution-state NMR and CD studies suggest γ-turn-like conformation in Pro-Amb analogs in aqueous solution. Furthermore, Pro-Amb analogs have been shown to act as AT2 receptor agonists.

Graphical abstract: Angiotensin II analogs comprised of Pro-Amb (γ-turn scaffold) as angiotensin II type 2 (AT2) receptor agonists

  • This article is part of the themed collection: Foldamers

Supplementary files

Article information

Article type
Communication
Submitted
23 Қар. 2015
Accepted
26 Қар. 2015
First published
26 Қар. 2015

Chem. Commun., 2016,52, 1645-1648

Angiotensin II analogs comprised of Pro-Amb (γ-turn scaffold) as angiotensin II type 2 (AT2) receptor agonists

G. S. Jedhe, A. S. Kotmale, P. R. Rajamohanan, S. Pasha and G. J. Sanjayan, Chem. Commun., 2016, 52, 1645 DOI: 10.1039/C5CC09687A

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