Issue 35, 2023

3D printing-mediated microporous starch hydrogels for wound hemostasis

Abstract

Starch hydrogels with biodegradability and cytocompatibility are good alternatives to traditional dressings. Herein, oxidized starch hydrogel loaded with coagulation factor Ca2+ ions (CaOMS) is successfully constructed by green hot-extrusion 3D printing technology (HE-3DP). In vitro study demonstrated the good water absorbing capacity (845.15–1194.20%) and blood cell and platelet adhesion of CaOMS to assist hemostasis owing to the boosted network structure density, gel strength, and the release of activated Ca2+ ions. More importantly, in vivo experiments further demonstrated CaOMS could maintain the weight loss caused by blood loss from wounds and has excellent hemostatic (65 s) and wound healing properties by promoting the secretion of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) expression. The advantages of CaOMS, including rapid and effective hemostasis, effective wound healing, low cost, easy usage, and adaptability to fit various wound shapes, make it a promising biomaterial for achieving fast hemostasis and wound healing.

Graphical abstract: 3D printing-mediated microporous starch hydrogels for wound hemostasis

  • This article is part of the themed collection: #MyFirstJMCB

Supplementary files

Article information

Article type
Paper
Submitted
24 Мам. 2023
Accepted
03 Шіл. 2023
First published
04 Шіл. 2023

J. Mater. Chem. B, 2023,11, 8411-8421

3D printing-mediated microporous starch hydrogels for wound hemostasis

B. Zheng, Z. Qiu, J. Xu, X. Zeng, K. Liu and L. Chen, J. Mater. Chem. B, 2023, 11, 8411 DOI: 10.1039/D3TB01189E

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