Issue 9, 2023

In situ stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment

Abstract

The individual motifs that respond to specific stimuli for the self-assembly of nanomaterials play important roles. In situ constructed nanomaterials are formed spontaneously without human intervention and have promising applications in bioscience. However, due to the complex physiological environment of the human body, designing stimulus-responsive self-assembled nanomaterials in vivo is a challenging problem for researchers. In this article, we discuss the self-assembly principles of various nanomaterials in response to the tissue microenvironment, cell membrane, and intracellular stimuli. We propose the applications and advantages of in situ self-assembly in drug delivery and disease diagnosis and treatment, with a focus on in situ self-assembly at the lesion site, especially in cancer. Additionally, we introduce the significance of introducing exogenous stimulation to construct self-assembly in vivo. Based on this foundation, we put forward the prospects and possible challenges in the field of in situ self-assembly. This review uncovers the relationship between the structure and properties of in situ self-assembled nanomaterials and provides new ideas for innovative drug molecular design and development to solve the problems in the targeted delivery and precision medicine.

Graphical abstract: In situ stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment

Article information

Article type
Review Article
Submitted
19 Сәу. 2023
Accepted
12 Мау. 2023
First published
14 Мау. 2023

Mater. Horiz., 2023,10, 3197-3217

In situ stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment

Z. Yan, Y. Liu, L. Zhao, J. Hu, Y. Du, X. Peng and Z. Liu, Mater. Horiz., 2023, 10, 3197 DOI: 10.1039/D3MH00592E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements