Issue 96, 2023

Concurrent Cu(ii)-initiated Fenton-like reaction and glutathione depletion to escalate chemodynamic therapy

Abstract

Chemodynamic therapy is an evolving therapeutic strategy but there are certain limitations associated with its treatment. Herein, we present de novo synthesis and mechanistic evaluation of HL1–HL8 ligands and their corresponding CuII(L1)2–CuII(L8)2. The most active Cu(L2)2 (IC50 = 5.3 μM, MCF-7) complex exclusively depletes glutathione while simultaneously promoting ROS production. Cu(L2)2 also affects other macromolecules like the mitochondrial membrane and DNA while activating the unfolded protein response cascade.

Graphical abstract: Concurrent Cu(ii)-initiated Fenton-like reaction and glutathione depletion to escalate chemodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
12 Қыр. 2023
Accepted
25 Қаз. 2023
First published
27 Қаз. 2023

Chem. Commun., 2023,59, 14305-14308

Concurrent Cu(II)-initiated Fenton-like reaction and glutathione depletion to escalate chemodynamic therapy

A. Kumar, A. Chaudhary, B. Agrahari, K. Chaudhary, P. Kumar and R. G. Singh, Chem. Commun., 2023, 59, 14305 DOI: 10.1039/D3CC04519F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements