Issue 17, 2022

Transition metal-free advanced synthetic approaches for isoindolinones and their fused analogues

Abstract

Isoindolinones are the core structures of many natural products and drug molecules and are useful in materials science as fluorescent probes and synthetic dyes. The fused analogues of these blended lactams also have a wide range of applications in medicinal chemistry and chemical biology. Different synthetic approaches and the use of versatile reagents have been reported for the synthesis of these novel molecules. Different research groups have focused their efforts on improving synthetic protocols towards the synthesis of the isoindolinone frame both in the presence and absence of transition metals. However, the transition metal-based pathway requires hazardous conditions, which are toxic to the environment. In particular, the transition metal-free synthetic protocols for isoindolinones and their fused analogues are highly fascinating due to several advantages for the industrial production of these bio-active molecules. These concepts encouraged us to write this review to highlight the recent advancements in the synthetic methods involving transition-metal-free approaches from 2007 to 2021. As the main feature of this review, we summarize the synthetic pathways for the isoindolinones, highlighting the synthetic precursors, which include different ortho-substituted aromatic substrates via multistep or tandem protocols, under metal-free conditions. We also discuss the mechanistic pathway of each methodology for the formation of isoindolinones.

Graphical abstract: Transition metal-free advanced synthetic approaches for isoindolinones and their fused analogues

Article information

Article type
Perspective
Submitted
27 Қаң. 2022
Accepted
02 Сәу. 2022
First published
05 Сәу. 2022

New J. Chem., 2022,46, 7780-7830

Transition metal-free advanced synthetic approaches for isoindolinones and their fused analogues

S. Samanta, S. A. Ali, A. Bera, S. Giri and K. Samanta, New J. Chem., 2022, 46, 7780 DOI: 10.1039/D2NJ00475E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements