Issue 14, 2021

Recent advances in transition metal-catalyzed reactions of carbamoyl chlorides

Abstract

The development of carbamoyl chlorides as synthons for various amide-containing molecules and heterocycles has been summarized and discussed in this review article. Carbamoyl chlorides can participate in a diverse range of transition metal-catalyzed transformations including radical initiated reactions and cross-coupling and annulation reaction modes as well as C–H functionalization to access amide-functionalized organic frameworks having extensive applications in pharmaceutical and natural product synthesis. This review mainly highlights the advancements of carbamoyl chlorides as a powerful synthetic tool in transition-metal catalyzed reactions over the last two decades. In addition, transition-metal catalyzed reactions of their corresponding structural analogs, carbamoyl fluorides and cyanides, with respect to their chemical behavior are also briefly reviewed.

Graphical abstract: Recent advances in transition metal-catalyzed reactions of carbamoyl chlorides

Article information

Article type
Review Article
Submitted
13 Қаң. 2021
Accepted
07 Сәу. 2021
First published
19 Сәу. 2021

Org. Chem. Front., 2021,8, 4024-4045

Recent advances in transition metal-catalyzed reactions of carbamoyl chlorides

M. Shrestha, X. Wu, W. Huang, J. Qu and Y. Chen, Org. Chem. Front., 2021, 8, 4024 DOI: 10.1039/D0QO01648A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements