Issue 24, 2021

Antitumor activity of tridentate pincer and related metal complexes

Abstract

Pincer complexes featuring tunable tridentate ligand frameworks are one of the most actively studied classes of metal-based complexes. Currently, growing attention is devoted to the cytotoxicity of pincer and related metal complexes. The antiproliferative activity of numerous pincer complexes has been reported. Pincer tridentate ligand scaffolds show different coordination modes and offer multiple options for directed structural modifications. This review summarizes the significant progress in the research studies of the antitumor activity of pincer and related platinum(II), gold(III), palladium(II), copper(II), iron(III), ruthenium(II), nickel(II) and some other metal complexes, in order to provide a reference for designing novel metal coordination drug candidates with promising antitumor activity.

Graphical abstract: Antitumor activity of tridentate pincer and related metal complexes

Article information

Article type
Review Article
Submitted
25 Нау. 2021
Accepted
04 Мам. 2021
First published
04 Мам. 2021

Org. Biomol. Chem., 2021,19, 5254-5273

Antitumor activity of tridentate pincer and related metal complexes

S. Wu, Z. Wu, Q. Ge, X. Zheng and Z. Yang, Org. Biomol. Chem., 2021, 19, 5254 DOI: 10.1039/D1OB00577D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements