Micelle enabled C(sp2)–C(sp3) cross-electrophile coupling in water via synergistic nickel and copper catalysis

Ning Ye; Bin Wu; Kangming Zhao; Xiaobin Ge; Yu Zheng; Xiaodong Shen; Lei Shi; Margery Cortes-Clerget; Morgan Louis Regnier; Michael Parmentier; Fabrice Gallou

doi:10.1039/D1CC02885E

Micelle enabled C(sp²)–C(sp³) cross-electrophile coupling in water via synergistic nickel and copper catalysis†

Ning Ye,

*^a Bin Wu,

*^a Kangming Zhao,‡^a Xiaobin Ge,‡^a Yu Zheng,^a Xiaodong Shen,^a Lei Shi,^a Margery Cortes-Clerget,^b Morgan Louis Regnier,^b Michael Parmentier

^b and Fabrice Gallou

*^b

Author affiliations

* Corresponding authors

^a Chemical & Analytical Development, Suzhou Novartis Technical Development Co., Ltd, Changshu, Jiangsu 215537, China
E-mail: ning.ye@novartis.com, bin-3.wu@novartis.com

^b Chemical & Analytical Development, Novartis Pharma AG, Basel 4056, Switzerland
E-mail: fabrice.gallou@novartis.com

Abstract

A robust and sustainable C(sp²)–C(sp³) cross-electrophile coupling was developed via nickel/copper synergistic catalysis under micellar conditions. This protocol provided a general method to access alkylated arenes with good to excellent yields on a very large scale.

This article is part of the themed collection: Green Synthesis

Chemical Communications

Micelle enabled C(sp²)–C(sp³) cross-electrophile coupling in water via synergistic nickel and copper catalysis†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Micelle enabled C(sp²)–C(sp³) cross-electrophile coupling in water via synergistic nickel and copper catalysis

Social activity

Search articles by author

Spotlight

Advertisements

Chemical Communications