Issue 8, 2019

Non-viral nanocarriers for intracellular delivery of microRNA therapeutics

Abstract

MicroRNAs are small regulatory noncoding RNAs that regulate various biological processes associated with neurological disorders, cardiovascular diseases, cancer and viral infection. MiRNA-based therapeutics have broad applications including cancer immunotherapy, genomic engineering and protein replacement therapy. Until now, a variety of materials have been proved to be promising as non-viral nanocarriers for intracellular delivery of miRNAs, such as polymeric nanoparticles, lipid nanocapsules, and inorganic nanoparticles, etc. In this review, we will present the strategies for intracellular miRNA delivery, and specially focus on rationally designed routes, their mechanisms of action, and potential therapeutics used in the host cells or in vivo studies. Futhermore, we will also make a conclusion based on the current development. The perspective on the new generation of delivery systems toward the emerging area of miRNA-based therapeutics will be discussed as well.

Graphical abstract: Non-viral nanocarriers for intracellular delivery of microRNA therapeutics

Article information

Article type
Review Article
Submitted
08 Қар. 2018
Accepted
07 Қаң. 2019
First published
07 Қаң. 2019

J. Mater. Chem. B, 2019,7, 1209-1225

Non-viral nanocarriers for intracellular delivery of microRNA therapeutics

Z. Bai, J. Wei, C. Yu, X. Han, X. Qin, C. Zhang, W. Liao, L. Li and W. Huang, J. Mater. Chem. B, 2019, 7, 1209 DOI: 10.1039/C8TB02946F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements