Issue 50, 2018

Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

Abstract

Since the first isolation of pseurotin A in 1976, over twenty five spirocyclic PKS-NRPS-based (polyketide synthase-nonribosomal peptide synthetase-based) fungal natural products have been discovered to date. The common 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione core of this family of natural products has served as a platform for the development of novel chemistry and resulted in the development of numerous new reactivities and synthetic strategies. Herein, we delineate all reported syntheses of spirocyclic PKS-NRPS-based fungal metabolites including our own recent contributions on this subject. We showcase how a biosynthetic consideration could lead to concise synthetic routes to this family of natural products.

Graphical abstract: Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

Article information

Article type
Feature Article
Submitted
23 Нау. 2018
Accepted
30 Мам. 2018
First published
30 Мам. 2018

Chem. Commun., 2018,54, 6750-6758

Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

D. Jo and S. Han, Chem. Commun., 2018, 54, 6750 DOI: 10.1039/C8CC02315H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements