Issue 10, 2016

Nanostructure-based surface-enhanced Raman scattering biosensors for nucleic acids and proteins

Abstract

Detection of nucleic acid and protein targets related to human health and safety has attracted widespread attention. Surface-enhanced Raman scattering (SERS) is a powerful tool for biomarker detection because of its ultrahigh detection sensitivity and unique fingerprinting spectra. In this review, we first introduce the development of nanostructure-based SERS-active substrates and SERS nanotags, which greatly influence the performance of SERS biosensors. We then focus on recent advances in SERS biosensors for DNA, microRNA and protein determination, including label-free, labeled and multiplex analyses as well as in vivo imaging. Finally, the prospects and challenges of such nanostructure-based SERS biosensors are discussed.

Graphical abstract: Nanostructure-based surface-enhanced Raman scattering biosensors for nucleic acids and proteins

Article information

Article type
Review Article
Submitted
13 Қаз. 2015
Accepted
13 Қаң. 2016
First published
13 Қаң. 2016

J. Mater. Chem. B, 2016,4, 1757-1769

Nanostructure-based surface-enhanced Raman scattering biosensors for nucleic acids and proteins

J. Chao, W. Cao, S. Su, L. Weng, S. Song, C. Fan and L. Wang, J. Mater. Chem. B, 2016, 4, 1757 DOI: 10.1039/C5TB02135A

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