Issue 25, 2016

Therapeutic application of anti-angiogenic nanomaterials in cancers

Abstract

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, plays a vital role in physiological and pathological processes (embryonic development, wound healing, tumor growth and metastasis). The overall balance of angiogenesis inside the human body is maintained by pro- and anti-angiogenic signals. The processes by which drugs inhibit angiogenesis as well as tumor growth are called the anti-angiogenesis technique, a most promising cancer treatment strategy. Over the last couple of decades, scientists have been developing angiogenesis inhibitors for the treatment of cancers. However, conventional anti-angiogenic therapy has several limitations including drug resistance that can create problems for a successful therapeutic strategy. Therefore, a new comprehensive treatment strategy using antiangiogenic agents for the treatment of cancer is urgently needed. Recently researchers have been developing and designing several nanoparticles that show anti-angiogenic properties. These nanomedicines could be useful as an alternative strategy for the treatment of various cancers using anti-angiogenic therapy. In this review article, we critically focus on the potential application of anti-angiogenic nanomaterial and nanoparticle based drug/siRNA/peptide delivery systems in cancer therapeutics. We also discuss the basic and clinical perspectives of anti-angiogenesis therapy, highlighting its importance in tumor angiogenesis, current status and future prospects and challenges.

Graphical abstract: Therapeutic application of anti-angiogenic nanomaterials in cancers

Supplementary files

Article information

Article type
Review Article
Submitted
09 Қар. 2015
Accepted
17 Нау. 2016
First published
21 Нау. 2016

Nanoscale, 2016,8, 12444-12470

Therapeutic application of anti-angiogenic nanomaterials in cancers

S. Mukherjee and C. R. Patra, Nanoscale, 2016, 8, 12444 DOI: 10.1039/C5NR07887C

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