Issue 30, 2016

Self-assembly of a 5-fluorouracil-dipeptide hydrogel

Abstract

The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23.

Graphical abstract: Self-assembly of a 5-fluorouracil-dipeptide hydrogel

  • This article is part of the themed collection: Foldamers

Supplementary files

Article information

Article type
Communication
Submitted
05 Ақп. 2016
Accepted
04 Нау. 2016
First published
09 Нау. 2016

Chem. Commun., 2016,52, 5254-5257

Self-assembly of a 5-fluorouracil-dipeptide hydrogel

Y. Sun, J. A. Kaplan, A. Shieh, H. Sun, C. M. Croce, M. W. Grinstaff and J. R. Parquette, Chem. Commun., 2016, 52, 5254 DOI: 10.1039/C6CC01195K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements