Issue 40, 2015

Systematic evaluation of natural scaffolds in cutaneous wound healing

Abstract

Current strategies to improve wound healing are often created from multiple components that may include a scaffold, cells, and bioactive cues. Acellular natural hydrogels are an attractive approach since the material's intrinsic biological activity can be paired with mechanical properties similar to soft tissue to induce a host's response toward healing. In this report, a systematic evaluation was conducted to study the effect of hydrogel scaffold implantation in skin healing using a human-relevant murine wound healing model. Fibrin, microporous hyaluronic acid, and composite hydrogels were utilized to study the effect of conductive scaffolds on the wound healing process. Composite hydrogels were paired with plasmin-degradable VEGF nanocapsules to investigate its impact as an inductive composite hydrogel on tissue repair. By 7 days, wound healing and vessel maturation within the newly formed tissue was significantly improved by the inclusion of porous scaffold architecture and VEGF nanocapsules.

Graphical abstract: Systematic evaluation of natural scaffolds in cutaneous wound healing

Supplementary files

Article information

Article type
Paper
Submitted
01 Мам. 2015
Accepted
21 Там. 2015
First published
21 Там. 2015

J. Mater. Chem. B, 2015,3, 7986-7992

Systematic evaluation of natural scaffolds in cutaneous wound healing

C. Cam, S. Zhu, N. F. Truong, P. O. Scumpia and T. Segura, J. Mater. Chem. B, 2015, 3, 7986 DOI: 10.1039/C5TB00807G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements