Themed collection Journal of Materials Chemistry B Recent Review Articles

Designing iron oxide & silver nanocomposites with phyto- and fungo chemicals for biomedicine: lessons learned
This work summarises our findings regarding multifunctional complex iron oxide and silver nanoparticles produced with the plants Z. officinale, H. perforatum and mushrooms A. muscaria, S. crispa.
J. Mater. Chem. B, 2025,13, 1500-1517
https://doi.org/10.1039/D4TB02284J
Unleashing the antibacterial potential of ZIFs and their derivatives: mechanistic insights
Exploring the mechanisms underlying the antibacterial activity of Zeolitic Imidazolate Frameworks (ZIFs) and their derivatives.
J. Mater. Chem. B, 2025,13, 3270-3291
https://doi.org/10.1039/D4TB02682A
Beyond DAD: proposing a one-letter code for nucleobase-mediated molecular recognition
This perspective outlines some key considerations for formulating a unified shorthand to describe nucleobase-mediated molecular recognition across chemical, biological, and materials contexts and proposes a naming scheme consistent therewith.
J. Mater. Chem. B, 2025,13, 485-495
https://doi.org/10.1039/D4TB01999G

Polymeric nanocarriers for cancer treatment: the promise of sensitive poly(2-(diisopropylamino)ethyl methacrylate)
Poly(2-(diisopropylamino)ethyl methacrylate) is a pH-responsive polymer and its copolymers can form nanosystems for the treatment of different types of cancer through gene therapy, drug delivery or photodynamic therapy.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D5TB00268K
Sacrificial MOFs on usage: Multifunctional compounds
J. Mater. Chem. B, 2025, Accepted Manuscript
https://doi.org/10.1039/D5TB00764J
Iodine-containing materials for biomedical applications
J. Mater. Chem. B, 2025, Accepted Manuscript
https://doi.org/10.1039/D5TB00534E
Key challenges and coping strategies for the detection of bacteria at ultralow concentrations
Research advances and effective coping strategies toward detection of bacteria with ultralow concentrations are presented.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D5TB00176E
Recent progress in ZIF–polymer composites for advanced drug delivery applications
This review article highlights recent advances in ZIF–polymer composites for drug delivery, emphasizing their applications across diverse routes including pulmonary, ocular, transdermal, gastrointestinal, and ortho delivery.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D5TB00147A
Progress of nanomaterials in the treatment of ischemic heart disease
This review constructs a dynamic and progressive pathological framework for the development of IHD, from MI to IRI and eventually to HF, systematically revealing the multidimensional therapeutic strategies of nanomaterials.
J. Mater. Chem. B, 2025,13, 6021-6043
https://doi.org/10.1039/D5TB00471C
Synthesis of versatile fluorescent isoquinolinium salts and their applications
This review highlights recent advances in fluorescent isoquinolinium salts, focusing on their applications in bioimaging, DNA binding, theranostics, and sensing.
J. Mater. Chem. B, 2025,13, 6044-6060
https://doi.org/10.1039/D5TB00286A
Chemical imaging for biological systems: techniques, AI-driven processing, and applications
Visualization of chemical compositions in biological samples has advanced through technologies such as single-molecule imaging, mass spectrometry, photoacoustic, Raman, and electrochemical microscopies, chemical probes, and AI-assisted processing.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D4TB02876G
Advanced 3D scaffolds for corneal stroma regeneration: a preclinical progress
Corneal stromal defects cause global blindness and entail unmet solutions beyond transplants. This review highlights scaffolds, biomaterials, and signaling cues in corneal stroma engineering to advance next-generation vision therapies.
J. Mater. Chem. B, 2025,13, 5980-6020
https://doi.org/10.1039/D5TB00090D
Versatility of LNPs across different administration routes for targeted RNA delivery
J. Mater. Chem. B, 2025, Accepted Manuscript
https://doi.org/10.1039/D5TB00575B
Surface Functionalization Strategies of ROS-Scavenging Nanozymes for Synergistic Therapy and Efficient Delivery
J. Mater. Chem. B, 2025, Accepted Manuscript
https://doi.org/10.1039/D5TB00877H
Ultrasound-responsive nanoweapons: covalent organic frameworks for cancer sonodynamic therapy
This review summarizes recent advancements in covalent organic framework (COF)-based cancer sonodynamic therapy, with an emphasis on the development of COF-based sonosensitizers and their significant roles in enhancing combination therapies.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D5TB00618J
Biomolecular interactions of carbon nanotubes with amyloid-β proteins
The primary CNT–Aβ binding dynamics include conjugation, hydrophobic interactions, Schiff base formation, hydrogen bonding, hydroxylation, Michael addition, biological reaction, and amidation reactions.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D5TB00153F
Influence of material format and surface chemistry for the sustained delivery and efficacy of silk drug delivery systems in vivo
In this study, the influence of material format and surface chemistry on the drug release and effectivity were evaluated to give insights on how silk drug delivery systems can be improved based on the target application.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D4TB02756F
A superior method for antitumor therapy and application: dual-ligand nanomedicines
Schematic illustration of dual-ligand nanomedicines navigating the tumor microenvironment and selectively targeting tumor cells through enhanced binding affinity and cellular uptake.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D5TB00044K
In vitro diagnosis based on SERS–LFIA: research hotspots, increase sensitivities, combined detection, multimodal detection and related patents
The schematic overview of in vitro diagnosis based on SERS-LFIA.
J. Mater. Chem. B, 2025,13, 5746-5761
https://doi.org/10.1039/D4TB02721C

The combined application of exosomes/exosome-based drug preparations and ultrasound
Exosomes are small extracellular vesicle, secreted by cells. Ultrasound can assist in the preparation of exosomes, drug loading into exosomes, targeted delivery of exosome-based drug formulations, cellular uptake, and adjuvant therapy.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D4TB01530D

Recent advances in 3D models for multiparametric blood–brain barrier detection in microfluidic systems
Microfluidics has emerged as a valuable technology for modeling the blood–brain barrier (BBB) to study physiological or pathological conditions and plays an important role in neuroscience and pharmaceutical research.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D4TB02499K
Differentiated strategies for nanovaccines in lymphoma immunotherapy: Advances and challenges
J. Mater. Chem. B, 2025, Accepted Manuscript
https://doi.org/10.1039/D5TB00528K
Photo-responsive antibacterial metal organic frameworks
Metal organic frameworks with diverse photo-responsive antibacterial mechanisms for biomedical applications are summarized.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D5TB00105F
Reprogramming and targeting of cholesterol metabolism in tumor-associated macrophages
This manuscript innovatively takes macrophages as the carrier and cholesterol metabolism as the core, describing in detail the topic of immune escape. It also reviews nanomaterials and clinical strategies for targeting cholesterol metabolism.
J. Mater. Chem. B, 2025,13, 5494-5520
https://doi.org/10.1039/D5TB00236B
miRNAs Electrochemical Biosensors based on MXene and MBene Nanomaterials: Recent Advances and Future Perspectives
J. Mater. Chem. B, 2025, Accepted Manuscript
https://doi.org/10.1039/D5TB00472A
Nanovehicles for delivery of antigens and adjuvants as cancer nanovaccines
This review summarizes cancer nanovaccine delivery via inorganic nanoparticles, polymeric nanovehicles, nanoengineered coordination polymers, lipid nanovehicles, biomimetic nanovehicles, virus-like particles, and self-assembled peptide vehicles.
J. Mater. Chem. B, 2025, Advance Article
https://doi.org/10.1039/D5TB00293A
Revolutionizing biosensing with wearable microneedle patches: innovations and applications
Wearable microneedle (MN) patches have emerged as a transformative platform for biosensing, offering a minimally invasive and user-friendly approach to real-time health monitoring and disease diagnosis.
J. Mater. Chem. B, 2025,13, 5264-5289
https://doi.org/10.1039/D5TB00251F
Recent advances in structural and functional design of electrospun nanofibers for wound healing
A schematic overview of electrospinning technology and the structure of electrospun nanofibers.
J. Mater. Chem. B, 2025,13, 5226-5263
https://doi.org/10.1039/D4TB02718C
Optimizing processes and unveiling the therapeutic potential of electrospun gelatin nanofibers for biomedical applications
Versatile gelatin nanofibers: revolutionizing biomedical innovations.
J. Mater. Chem. B, 2025,13, 5202-5225
https://doi.org/10.1039/D4TB02769H
Recent developments in polymer chemistry, medicinal chemistry and electro-optics using Ni and Pd-based catalytic systems
Catalytic systems based on transition metal ions, especially palladium and nickel ions, have gained great interest, due to the variety of their structures, their ability to bind with other molecules and to stabilize active centers to form catalysts.
J. Mater. Chem. B, 2025,13, 4964-4993
https://doi.org/10.1039/D4TB02859G
Re-engineering bone: pathogenesis, diagnosis and emerging therapies for osteoporosis
Understanding and exploring pathogenesis, diagnosis and emerging therapies for osteoporosis treatment.
J. Mater. Chem. B, 2025,13, 4938-4963
https://doi.org/10.1039/D4TB02628D
Vegetable oil-derived functional polymers in biomedical applications: hurdles and possibilities
Vegetable oil-derived sustainable alternatives to petrochemical-based synthetic polymers for biomedical applications.
J. Mater. Chem. B, 2025,13, 4994-5022
https://doi.org/10.1039/D4TB02648A
Strategic use of nanomaterials as double-edged therapeutics to control carcinogenesis via regulation of dysbiosis and bacterial infection: current status and future prospects
The present review focusses on an innovative therapeutic approach utilizing nanoparticle based strategies to simultaneously combat bacterial and cancer cell progression via targeting common cell surface receptors.
J. Mater. Chem. B, 2025,13, 4770-4790
https://doi.org/10.1039/D4TB02409E
Nanostructured conductive polymers: synthesis and application in biomedicine
This mini-review provides an overview of nanostructured conductive polymers, focusing on their synthesis methodologies and burgeoning applications in biomedicine.
J. Mater. Chem. B, 2025,13, 4739-4769
https://doi.org/10.1039/D4TB02513J
The design principle of natural polysaccharide hydrogels for promoting wound healing: a prospective review
Schematic illustration of multifunctional polysaccharide-based hydrogels for enhanced wound healing.
J. Mater. Chem. B, 2025,13, 4722-4738
https://doi.org/10.1039/D4TB02576H
Ultrasound-responsive smart biomaterials for bone tissue engineering
Bone defects resulting from trauma, tumors, or other injuries significantly impact human health and quality of life.
J. Mater. Chem. B, 2025,13, 4527-4543
https://doi.org/10.1039/D5TB00109A
Heterogeneous piezo-self-Fenton material design: an intersecting solution for pollutant degradation and tumor therapy
The commonalities and differences of EPSF catalysts in organic pollutant degradation and tumor-targeted therapy are summarized, focusing on catalytic mechanisms, material systems, performance enhancement strategies, and catalyst design.
J. Mater. Chem. B, 2025,13, 4544-4569
https://doi.org/10.1039/D4TB02558J
Advancements in regenerative medicine: a comprehensive review of stem cell and growth factor therapies for osteoarthritis
The regenerative potential of stem cells and growth factors and their promising roles in revolutionizing osteoarthritis treatment. The image was generated using BioRender.
J. Mater. Chem. B, 2025,13, 4494-4526
https://doi.org/10.1039/D4TB01769B
Sequential drug release nanocomposites for synergistic therapy in disease treatment
This review introduces the sequential drug release categories and release strategies of diverse nanocomposites and summarizes their sequential drug release emerging trends and challenges.
J. Mater. Chem. B, 2025,13, 4313-4329
https://doi.org/10.1039/D5TB00026B
MXenes and MXene-based composites for biomedical applications
MXenes, a novel class of two-dimensional materials, have recently emerged as promising candidates for biomedical applications due to their specific structural features and exceptional physicochemical and biological properties.
J. Mater. Chem. B, 2025,13, 4279-4312
https://doi.org/10.1039/D4TB02834A
Urease-coupled systems and materials: design strategies, scope and applications
This review illustrates the various ways for urease immobilization on solid supports. It also highlights how compartmentalized urease-driven reaction networks offer a viable platform for developing next-generation materials and chemical systems.
J. Mater. Chem. B, 2025,13, 4252-4278
https://doi.org/10.1039/D4TB02853H

Oral mucosa: anti-inflammatory function, mechanisms, and applications
The oral mucosa exhibits promise for scar-free tissue repair by rapid healing and anti-fibrosis. Its anti-inflammatory properties, combined with cell therapies and bioengineering, enable regenerative strategies for extra-oral applications.
J. Mater. Chem. B, 2025,13, 4059-4072
https://doi.org/10.1039/D4TB02845G
Tailoring nanovectors for optimal neoantigen vaccine efficacy
Insight into the advancements of neoantigen vaccine formulations. A comprehensive summary is presented on nanovectors designed to stimulate neoantigen-specific cytotoxic T cells for optimizing neoantigen vaccine efficacy.
J. Mater. Chem. B, 2025,13, 4045-4058
https://doi.org/10.1039/D4TB02547D
Functionalized ZIF-8 as a versatile platform for drug delivery and cancer therapy: strategies, challenges and prospects
This review discusses the functionalization strategies of ZIF-8 and challenges and future developments in ZIF-8-based platforms for drug delivery and cancer therapy.
J. Mater. Chem. B, 2025,13, 3758-3785
https://doi.org/10.1039/D4TB02289K
Comprehensive insights into electrochemical nicotine sensing technologies
Electrochemical sensing of nicotine using nanostructured materials modified electrodes.
J. Mater. Chem. B, 2025,13, 3831-3851
https://doi.org/10.1039/D4TB02753A
Bacterial outer membrane vesicles in tumor prevention and treatment: advancements in research and application
As one of the major challenges to global health, the innovation of prevention and treatment methods for tumors has consistently been a focal point in medical research.
J. Mater. Chem. B, 2025,13, 3786-3805
https://doi.org/10.1039/D4TB01899K

Metallic nanomaterials in Parkinson's disease: a transformative approach for early detection and targeted therapy
This review article illustrates and discusses the application of metallic nanomaterials (MNMs) in the detection and treatment of PD, as well as theranostic MNMs.
J. Mater. Chem. B, 2025,13, 3806-3830
https://doi.org/10.1039/D4TB02428A
Advancements in 3D gel culture systems for enhanced angiogenesis in bone tissue engineering
Various processing technologies for a 3D gel culture system used in bone tissue angiogenesis: bioprinting, organ decellularization, microfluidics, photolithography and electrospinning.
J. Mater. Chem. B, 2025,13, 3516-3527
https://doi.org/10.1039/D4TB01139B
Application of silk fibroin-based composite films in biomedicine and biotechnology
This article provides a comprehensive examination of recent advancements in silk fibroin-based composite films, with a focus on their applications in bone regeneration, wound healing, and health monitoring.
J. Mater. Chem. B, 2025,13, 3494-3515
https://doi.org/10.1039/D4TB02616K
Precision therapeutics for inflammatory bowel disease: advancing ROS-responsive nanoparticles for targeted and multifunctional drug delivery
This review discusses ROS-responsive nanoparticles in IBD therapy, highlighting challenges, solutions, and the “layered programmable delivery” strategy for enhanced drug delivery and localized treatment.
J. Mater. Chem. B, 2025,13, 3245-3269
https://doi.org/10.1039/D4TB02868F
Next-generation biopolymer gels: innovations in drug delivery and theranostics
Theranostic use of smart gels for precise treatment and drug delivery.
J. Mater. Chem. B, 2025,13, 3222-3244
https://doi.org/10.1039/D4TB02068E
Nanomaterials and clinical SERS technology: broad applications in disease diagnosis
In this review, we highlight the advancements in clinical SERS diagnostics, the role of NMs-SERS and AI in enhancing SERS data analysis for precise diagnosis of chronic diseases and improving detection sensitivity, specificity, and reproducibility.
J. Mater. Chem. B, 2025,13, 2890-2911
https://doi.org/10.1039/D4TB02525C
Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting the limitations of current cuproptosis related copper-based nanomaterials.
J. Mater. Chem. B, 2025,13, 2978-2999
https://doi.org/10.1039/D4TB02746A
Representative modeling of biocompatible MXene nanocomposites for next-generation biomedical technologies and healthcare
MXenes are a class of 2D transition metal carbides and nitrides (Mn+1XnT) that have attracted significant interest owing to their remarkable potential in various fields.
J. Mater. Chem. B, 2025,13, 2912-2951
https://doi.org/10.1039/D4TB02478H
Xanthene-based NIR organic phototheranostics agents: design strategies and biomedical applications
Near-infrared fluorescence imaging is key in biological exploration. Short emission wavelengths of xanthene dyes limit their use. Structural modifications shift emissions to the NIR-I/II range, enhancing their biomedical applications.
J. Mater. Chem. B, 2025,13, 2952-2977
https://doi.org/10.1039/D4TB02480J
Mechanistic understanding of pH as a driving force in cancer therapeutics
The development of pH-directed nanoparticles for tumor targeting represents a significant advancement in cancer biology and therapeutic strategies.
J. Mater. Chem. B, 2025,13, 2640-2657
https://doi.org/10.1039/D4TB02083A
Versatile hydrogels prepared by microfluidics technology for bone tissue engineering applications
This review comprehensively discusses the progress and future applications of microfluidic hydrogel technology in bone regeneration, especially their advantages over traditionally prepared hydrogels in bone tissue engineering.
J. Mater. Chem. B, 2025,13, 2611-2639
https://doi.org/10.1039/D4TB02314E

Programmable short peptides for modulating stem cell fate in tissue engineering and regenerative medicine
The schematic representation of biomedical applications of short peptides in cancer therapy, regenerative medicine, and tissue engineering.
J. Mater. Chem. B, 2025,13, 2573-2591
https://doi.org/10.1039/D4TB02102A
Advances in adhesion of microneedles for bioengineering
Microneedles require robust adhesion to perform well in challenging environments. Advanced adhesion mechanisms enable specialized designs, ensuring comfort and effectiveness for diverse medical and therapeutic applications.
J. Mater. Chem. B, 2025,13, 2592-2610
https://doi.org/10.1039/D4TB02517B
Exploring the multifaceted roles of metal–organic frameworks in ecosystem regulation
This review provides a comprehensive analysis on the applications of various MOFs in both microbial eradication and protection, emphasizing their potential as promising smart materials in the field of ecosystem regulation.
J. Mater. Chem. B, 2025,13, 2272-2294
https://doi.org/10.1039/D4TB01882F

Evolution of branched peptides as novel biomaterials
Branched peptide-based systems mimic dendritic structures to improve biomaterial performance for medical applications with slower degradation, greater stiffness, and self-assembly capabilities.
J. Mater. Chem. B, 2025,13, 2226-2241
https://doi.org/10.1039/D4TB01897D
Biodegradable semiconducting polymer nanoparticles for phototheranostics
This review summarizes recent advances in biodegradable semiconducting polymer nanoparticles for phototheranostics, such as tumor imaging, lymph node imaging, as well as phototherapy, photo-immunotherapy, and anti-infection therapy.
J. Mater. Chem. B, 2025,13, 2242-2253
https://doi.org/10.1039/D4TB02437K
Plant-derived exosome-like nanoparticles in tissue repair and regeneration
This article reviews the extraction and characterization of ELNs, discussing their structure-function relationship. It examines recent advances in ELNs for tissue regeneration and highlights challenges and future directions in tissue repair and regeneration.
J. Mater. Chem. B, 2025,13, 2254-2271
https://doi.org/10.1039/D4TB02394C
A promising mesoporous silica carrier material for the diagnosis and treatment of liver diseases: recent research advances
The therapeutic diagnosis of liver diseases has garnered significant interest within the medical community.
J. Mater. Chem. B, 2025,13, 1935-1960
https://doi.org/10.1039/D4TB01822B

Collagen as a bio-ink for 3D printing: a critical review
The significance of three-dimensional (3D) bioprinting in the domain of regenerative medicine and tissue engineering is readily apparent.
J. Mater. Chem. B, 2025,13, 1890-1919
https://doi.org/10.1039/D4TB01060D
The application of aptamers in the repair of bone, nerve, and vascular tissues
Schematic diagram of the application of aptamers in the repair of bone, nerve, and vascular tissues.
J. Mater. Chem. B, 2025,13, 1872-1889
https://doi.org/10.1039/D4TB02180K
Drug delivery systems loaded with plant-derived natural products for dental caries prevention and treatment
Schematic diagram of drug delivery system for dental caries prevention and treatment.
J. Mater. Chem. B, 2025,13, 1920-1934
https://doi.org/10.1039/D4TB01924E
Advances in nanozymes with peroxidase-like activity for biosensing and disease therapy applications
This review explores the different types of nanozymes with POD-like activity and discusses their activity regulation, particularly emphasizing their latest development trends and advances in biosensing and disease treatment.
J. Mater. Chem. B, 2025,13, 1599-1618
https://doi.org/10.1039/D4TB02315C
Exosomes of different cellular origins: prospects and challenges in the treatment of acute lung injury after burns
The unique properties of exosomes and their applications in ALI, particularly in the delivery of diverse drug molecules, are summarized. Additionally, the current challenges of the use of exosomes in the treatment of ALI are proposed.
J. Mater. Chem. B, 2025,13, 1531-1547
https://doi.org/10.1039/D4TB02351J
Emerging biosensing platforms based on metal–organic frameworks (MOFs) for detection of exosomes as diagnostic cancer biomarkers: case study for the role of the MOFs
The different roles of MOFs as carriers, labels, electrode modifiers, and fluorescence quenchers for the detection of exosomes are discussed.
J. Mater. Chem. B, 2025,13, 1586-1598
https://doi.org/10.1039/D4TB02465F
About this collection
This collection contains recent Review-type articles published by Journal of Materials Chemistry B, the home for high impact applications, properties and synthesis of exciting new materials for biology and medicine.
New articles will be added to this collection as soon as possible after publication.