Drug-like molecules designed by fragment growing strategy on isocytosine and acyl guanidine warheads as BACE1 inhibition. In vivo characterization of top-active benzimidazoles (16a, 16k) showed Aβ/oxidation stress reduction and brain/liver safety.
This review highlights the potential of multi-target-directed strategies that address amyloid-β aggregation, metal ion dyshomeostasis, and enzyme dysfunction, offering a comprehensive and effective approach to treating Alzheimer's disease.
Fucoxanthin ameliorates Aβ pathology, including Aβ and pE3-Aβ expression, by modulating APP processing and suppressing QC via PI3K/Akt/GSK-3β signaling, ultimately leading to cognitive improvement.
New phosphazine and triazole derivatives were synthesized and evaluated as potential anti-Alzheimer's agents. The compounds modulate ROS/JNK and Wnt/β-catenin pathways, showing promising neuroprotective activities.
Dietary eicosapentaenoic acid (EPA) mitigates the cognitive decline from chronic sleep deprivation via multi-target regulation of the gut–brain cerebral β-amyloid axis showing EPA-enriched functional foods could be used to manage sleep disturbance.