Novel, fluorinated glycopeptide antibiotics (GPAs) have been generated using mutasynthesis approaches. This also expands our knowledge of the tolerance of modified phenylglycine amino acid residues by the GPA biosynthetic assembly machinery.
6,8-Ditrifluoromethyl halogenated phenazine potently eradicates Gram-positive bacterial biofilm communities that demonstrate innate tolerance to all classes of conventional antibiotics.
A rapid and simple multicolor immunosensor was developed for monitoring of vancomycin concentration, and the immunosensor presented good color stability, user friendliness and portability.
Drug-resistant bacteria are a rising menace, rendering many antibiotics powerless. This review explores the role of DNA-encoded chemical libraries as a game-changer, uncovering new antibacterial agents and sparking hope in the battle against antimicrobial resistance.
The split-aptamer assay exploits the balance between aptamer affinity and structure for real-time monitoring of vancomycin on SPR. Further optimization improved sensitivity, while retaining repeatability under physiologically relevant conditions.