Saponins Based on Medicinal and Edible Homologous Plants: Biological Activity, Delivery Systems and Its Application in Healthy Foods

Siwen Chen, Ying Zhou, Huiliang Li, Lijun You, Sandra Pedisić and Ping Shao

Food Bioengineering, 2024, 3, 464
DOI: 10.1002/fbe2.12111

Vitamin K is involved in liver protection and repair: Mitigating hepatotoxicity induced by the nitrite environment in grass carp (Ctenopharyngodon idella) by modulating Golgi function, hepatic stellate cells and mitochondrial dynamics

Jian-Fei Wang, Wei-Dan Jiang, Pei Wu, Yao-Bin Ma, Hong-Yun Zhang, Yang Liu, Lu Zhang, Hai-Feng Mi, Lin Feng and Xiao-Qiu Zhou

Aquaculture, 2026, 615, 743635
DOI: 10.1016/j.aquaculture.2026.743635

Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatment of diabetes and its complications: An update since 2010

Qian-Ru Lin, Lian-Qun Jia, Ming Lei, Di Gao, Nan Zhang, Lei Sha, Xu-Han Liu and Yu-Dan Liu

Pharmacological Research, 2024, 200, 107054
DOI: 10.1016/j.phrs.2023.107054

Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway

Yan Long, Xiaodong Ge, Liangliang Ma, Junhua Guo and Yong Zhu

Open Medicine, 2024, 19
DOI: 10.1515/med-2024-1036

Cross-cultural comparison of antidiabetic medicinal plants used in Algeria and Morocco

Sarra Maamri, Mourad Djeziri, Souhila Mendil and Lydia Terfi

Journal of Herbal Medicine, 2025, 53, 101043
DOI: 10.1016/j.hermed.2025.101043

Natural small molecules regulating the mitophagy pathway counteract the pathogenesis of diabetes and chronic complications

Du Ye, Junping Zhu, Siya Su, Yunfeng Yu, Jun Zhang, Yuman Yin, Chuanquan Lin, Xuejiao Xie, Qin Xiang and Rong Yu

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1571767

A natural products solution to diabetic nephropathy therapy

Qichao Hu, Lan Jiang, Qi Yan, Jinhao Zeng, Xiao Ma and Yanling Zhao

Pharmacology & Therapeutics, 2023, 241, 108314
DOI: 10.1016/j.pharmthera.2022.108314

Identification of endoplasmic reticulum stress-related biomarkers of diabetes nephropathy based on bioinformatics and machine learning

Jiaming Su, Jing Peng, Lin Wang, Huidi Xie, Ying Zhou, Haimin Chen, Yang Shi, Yan Guo, Yicheng Zheng, Yuxin Guo, Zhaoxi Dong, Xianhui Zhang and Hongfang Liu

Front. Endocrinol., 2023, 14
DOI: 10.3389/fendo.2023.1206154

Diosgenin Targets CaMKK2 to Alleviate Type II Diabetic Nephropathy through Improving Autophagy, Mitophagy and Mitochondrial Dynamics

Yujie Zhong, Ruyi Jin, Ruilin Luo, Jiayu Liu, Luting Ren, Yinghan Zhang, Zhongguo Shan and Xiaoli Peng

Nutrients, 2023, 15, 3554
DOI: 10.3390/nu15163554

Modulating the gut microbiota and inflammation is involved in the effect of diosgenin against diabetic nephropathy in rat

Jiang Shanshan, Pan Shu, Hu Xiao, Kudelaidi Kuerban, Zhu Hao, Wang Yujie, Wang Rong, Shi Yuhuan and Yuan Yongfang

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1555849

Saponin monomers: Potential candidates for the treatment of type 2 diabetes mellitus and its complications

Lvzhuo Zhang, Shifeng He, Lian Liu and Jiangrong Huang

Phytotherapy Research, 2024, 38, 3564
DOI: 10.1002/ptr.8229

Mitochondria-targeting therapeutic strategies for chronic kidney disease

Annie Sun, Carol A. Pollock and Chunling Huang

Biochemical Pharmacology, 2025, 231, 116669
DOI: 10.1016/j.bcp.2024.116669

New concepts drive the development of delivery tools for sustainable treatment of diabetic complications

Jianan Zheng, Ru Wang and Yibing Wang

Biomedicine & Pharmacotherapy, 2024, 171, 116206
DOI: 10.1016/j.biopha.2024.116206

Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism

Tianyu Zhang, Wenjuan Sun, Lixin Wang, Hui Zhang, Yuansong Wang, Baochao Pan, Hanzhou Li, Ziang Ma, Kai Xu, Huantian Cui, Shuquan Lv and Rosa Fernandes

Journal of Diabetes Research, 2023, 2023, 1
DOI: 10.1155/2023/9164883

A peptide from Boletus griseus‐Hypomyces chrysospermus protects against hypertension and associated cardiac and renal damage through modulating RAAS and intestinal microbiota

Pengtao Huan, Liping Sun, Shupeng Chen, Yujie Zhong and Yongliang Zhuang

Journal of Food Science, 2025, 90
DOI: 10.1111/1750-3841.17617

Effect of the glucagon-like peptide-1 receptor agonists dulaglutide on kidney outcomes in db/db mice

Fengyi Deng, Ping Zhang, Huaiyun Li, Xingyu Fan, Yijun Du, Xing Zhong, Nuojin Wang, Meiwen He, Yue Wang and Tianrong Pan

Cellular Signalling, 2025, 127, 111603
DOI: 10.1016/j.cellsig.2025.111603

Isoliquiritigenin Alleviates Diabetic Kidney Disease via Oxidative Stress and the TLR4/NF‐κB/NLRP3 Inflammasome Pathway

Yanhong Wang, Jia Yang, Xinyue Chang, Yuan Xue, Gaohong Liu, Tingting Zhang, Weihao Chen, Weiping Fan, Jihua Tian and Xiaojun Ren

Molecular Nutrition Food Res, 2024, 68
DOI: 10.1002/mnfr.202400215

Dioscin improves fatty liver hemorrhagic syndrome by promoting ERα-AMPK mediated mitophagy in laying hens

Yuxiao Xing, Benzeng Huang, Ziyi Cui, Quanwei Zhang and Haitian Ma

Phytomedicine, 2024, 135, 156056
DOI: 10.1016/j.phymed.2024.156056

Molecular Mechanistic Pathways Targeted by Natural Compounds in the Prevention and Treatment of Diabetic Kidney Disease

Kaixuan Zhou, Xue Zi, Jiayu Song, Qiulu Zhao, Jia Liu, Huiwei Bao and Lijing Li

Molecules, 2022, 27, 6221
DOI: 10.3390/molecules27196221

Nephroprotective effects of honokiol in a high-fat diet-streptozotocin rat model of diabetic nephropathy

Ishfaq Ahmad Rather, Nadeem Khan, Ajay Singh Kushwah, Gurunath Surampalli and Manish Kumar

Life Sciences, 2023, 320, 121543
DOI: 10.1016/j.lfs.2023.121543

Anacardic acid ameliorates insulin resistance and diabetic nephropathy: network pharmacology, in vivo and molecular docking studies targeting TNF- α / TGFβR1 signaling

Gehad Elshamy, Hany M. El-Bassossy, Shimaa M. Elshazly and Nesreen M. I. M. Elkomy

J Nat Med, 2025
DOI: 10.1007/s11418-025-01960-0

Responses of bitter melon saponins to oxidative stress and aging via the IIS pathway linked with sir‐2.1 and hlh‐30

Jinfu Zhang, Linzhao He, Anlin Wang, Beiqi Wu, Peixi Zhang, Ying Zhu, Ya Jiang, Juan Bai and Xiang Xiao

Journal of Food Biochemistry, 2022, 46
DOI: 10.1111/jfbc.14456

Comprehensive review of tujia “Lian” medicinal botanical drugs: traditional classification system, phytochemical, and pharmacological profile

Nan Kuang, Yu Mao, Muhammad Aamer, Piaopiao Jiang, Feibing Huang, Yupei Yang, Wenbing Sheng, Caiyun Peng, Wei Wang and Bin Li

Front. Pharmacol., 2026, 17
DOI: 10.3389/fphar.2026.1747999

Modified Zn-MOF multifunctional nanoparticles for combination therapy of DN and exploratory study of the nephroprotective effect

Yuna Tong, Xiuxiu Li, Yuxuan Zhu, Xiaohui Liao and Ling Zhang

Biomedicine & Pharmacotherapy, 2025, 192, 118713
DOI: 10.1016/j.biopha.2025.118713

Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling

Shuang Wang, Yingce Zheng, Shengzi Jin, Yunwei Fu and Yun Liu

Antioxidants, 2022, 11, 2443
DOI: 10.3390/antiox11122443

Natural compounds improve diabetic nephropathy by regulating the TLR4 signaling pathway

Jiabin Wu, Ke Li, Muge Zhou, Haoyang Gao, Wenhong Wang and Weihua Xiao

Journal of Pharmaceutical Analysis, 2024, 14, 100946
DOI: 10.1016/j.jpha.2024.01.014

Therapeutic potential of common Phytoestrogens found in traditional Chinese medicine in chronic kidney diseases

Tongtong Liu and Minghan Li

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1599097

Mitochondrial quality control in diabetes mellitus and complications: molecular mechanisms and therapeutic strategies

Yanling Chen, Xun Liu, Yixuan Liu, Yujia Li, Dingxiang Li, Zhigang Mei and Yihui Deng

Cell Death Dis, 2025, 16
DOI: 10.1038/s41419-025-07936-y

Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy

Fengzhao Liu, Zhenyu Yang, Jixin Li, Tao Wu, Xiangyu Li, Lijuan Zhao, Wenru Wang, Wenfei Yu, Guangheng Zhang and Yunsheng Xu

Mol Med, 2024, 30
DOI: 10.1186/s10020-024-01020-5

N-acetyl-L-cysteine alleviates FUNDC1-mediated mitophagy by regulating mitochondrial dynamics in type 1 diabetic nephropathy canine

Feiyang Ma, Huayu Li, Haihua Huo, Qingyue Han, Jianzhao Liao, Hui Zhang, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo and Zhaoxin Tang

Life Sciences, 2023, 313, 121278
DOI: 10.1016/j.lfs.2022.121278

Dioscin regulates oxidative stress and autophagy in uric acid-induced HK-2 cells through the P62-KEAP1-NRF2 signaling pathway

Jiashu Feng, Weiliang Zhang, Ruiqi Liu, Ting Xiang and Xinlin Wu

BMC Nephrol, 2025, 26
DOI: 10.1186/s12882-025-04311-z

Melatonin alleviates renal injury in diabetic rats by regulating autophagy

Na Luo, Yangyang Wang, Yonggang Ma, Yu Liu and Zongping Liu

Mol Med Rep, 2023, 28
DOI: 10.3892/mmr.2023.13101

Dioscin alleviates Alzheimer's disease through regulating RAGE/NOX4 mediated oxidative stress and inflammation

Linshu Guan, Zhang Mao, Sen Yang, Guanlin Wu, Yurong Chen, Lianhong Yin, Yan Qi, Lan Han and Lina Xu

Biomedicine & Pharmacotherapy, 2022, 152, 113248
DOI: 10.1016/j.biopha.2022.113248

The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications

Ziwei Zhang, Qingxia Huang, Daqing Zhao, Fengmei Lian, Xiangyan Li and Wenxiu Qi

Front. Endocrinol., 2023, 14
DOI: 10.3389/fendo.2023.1112363

Mechanism of dioscin ameliorating renal fibrosis through NF‑κB signaling pathway‑mediated inflammatory response

Yang Wang, Peng Liu, Guijie Ma, Chenguang Wu, Wenhui Zhu, Pengce Sun, Wenya Lu, Xinyu Yang, Yilun Zhang, Na Liu and Ping Li

Mol Med Rep, 2023, 27
DOI: 10.3892/mmr.2023.12980

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

Fengzhao Liu, Lijuan Zhao, Tao Wu, Wenfei Yu, Jixin Li, Wenru Wang, Chengcheng Huang, Zhihao Diao and Yunsheng Xu

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1364616

Challenging directions in pediatric diabetes - the place of oxidative stress and antioxidants in systemic decline

Vasile Valeriu Lupu, Ingrith Miron, Laura Mihaela Trandafir, Elena Jechel, Iuliana Magdalena Starcea, Ileana Ioniuc, Otilia Elena Frasinariu, Adriana Mocanu, Florin Dumitru Petrariu, Ciprian Danielescu, Alin Horatiu Nedelcu, Delia Lidia Salaru, Ninel Revenco and Ancuta Lupu

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1472670

Dioscin pretreatment ameliorates ferroptosis in cardiomyocytes after myocardial infarction via inhibiting endoplasmic reticulum stress

Chang Wu, Xueping Shen, Pan Lou and Dongyan Song

Mol Med, 2025, 31
DOI: 10.1186/s10020-025-01102-y

New Insights into Baicalein’s Effect on Chlorpyrifos-Induced Liver Injury in Carp: Involving Macrophage Polarization and Pyropto sis

Jing Liu, Wenyue Zhang, Xiaojing Li and Shiwen Xu

J. Agric. Food Chem., 2023, 71, 4132
DOI: 10.1021/acs.jafc.2c08580

Autophagy and the pancreas: Healthy and disease states

Zixian Zhou, Pengcheng Zhang, Juan Li, Jiaqi Yao, Yuhong Jiang, Meihua Wan, Wenfu Tang and Ling Liu

Front. Cell Dev. Biol., 2024, 12
DOI: 10.3389/fcell.2024.1460616

Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products

Guo Chen, Ya Zhang, Yaqiao Zhou, Hao Luo, Hongzhi Guan and Baiping An

JIR, 2024, Volume 17, 10421
DOI: 10.2147/JIR.S501270

Selective Autophagy in Kidney Diseases: The Tip of the Iceberg

Qiaofei Zhang, Xinyue Zhang, Hongyong Su, Ning An, Siqiao Gong, Xiaocui Chen, Mahyar Khazaeli, Huafeng Liu and Chen Yang

Integr Med Nephrol Androl, 2025, 12
DOI: 10.1097/IMNA-D-24-00036

Nox4 as a novel therapeutic target for diabetic vascular complications

Dongxia Wang, Jiaying Li, Gang Luo, Juan Zhou, Ning Wang, Shanshan Wang, Rui Zhao, Xin Cao, Yuxia Ma, Gang Liu and Liping Hao

Redox Biology, 2023, 64, 102781
DOI: 10.1016/j.redox.2023.102781

Based on network pharmacology, the mechanism of Dioscin in alleviating renal tubular epithelial cell injury induced by calcium oxalate crystals was explored

Hu Liang, Yuexian Xu, Shuai Sun, Yang Chen, Wei Wang and Zongyao Hao

Urolithiasis, 2024, 53
DOI: 10.1007/s00240-024-01673-1

Bioactive compounds from Polygonatum genus as anti-diabetic agents with future perspectives

Yan Shi, Dun Si, Donghong Chen, Xinfeng Zhang, Zhigang Han, Qiang Yu, Jingjing Liu and Jinping Si

Food Chemistry, 2023, 408, 135183
DOI: 10.1016/j.foodchem.2022.135183

Planting a path to kidney health: The vegetarian diet and diabetic nephropathy

Mudasir Maqbool, Mohd Altaf Dar and Irfat Ara

Open Health, 2023, 4
DOI: 10.1515/ohe-2023-0011

Allium hookeri extracts inhibit cisplatin-induced apoptosis and inflammation in human kidney HEK-293 cells

Ha-Rin Moon, Wooje Lee and Jung-Mi Yun

Food & Nutrition Research, 2025, 69
DOI: 10.29219/fnr.v69.10764

Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy

Yujie Zhong, Lei Wang, Ruyi Jin, Jiayu Liu, Ruilin Luo, Yinghan Zhang, Lin Zhu and Xiaoli Peng

Nutrients, 2023, 15, 2164
DOI: 10.3390/nu15092164

Thinned young apple powder prevents obesity-induced neuronal apoptosis via improving mitochondrial function of cerebral cortex in mice

Jiacheng Fang, Peng Jiang, Xincen Wang, Zhongshi Qi, Xin He, Lei Chen, Yurong Guo, Xiaoyun Xu, Run Liu and Duo Li

The Journal of Nutritional Biochemistry, 2024, 126, 109588
DOI: 10.1016/j.jnutbio.2024.109588

Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease

Peng Liu, Wenhui Zhu, Yang Wang, Guijie Ma, Hailing Zhao and Ping Li

Front. Endocrinol., 2023, 14
DOI: 10.3389/fendo.2023.1142805

Dioscin: Therapeutic potential for diabetes and complications

Haoyang Gao, Ze Wang, Danlin Zhu, Linlin Zhao and Weihua Xiao

Biomedicine & Pharmacotherapy, 2024, 170, 116051
DOI: 10.1016/j.biopha.2023.116051

Jiangniaosuan formula inhibits hyperuricemia-induced apoptosis of renal tubular epithelial cells via ROS/HIF-1α/EZH2 pathway: A network pharmacology analysis and experimental validation

Jiabao Zhou, Feng Yang, Xuming Zhang, Chuanxu Wang, Zhiyuan Wu and Jiandong Gao

Bioorganic Chemistry, 2025, 159, 108363
DOI: 10.1016/j.bioorg.2025.108363

Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice

Wanying Cheng, Cenzhu Wang, Meican Ma and Yu Zhou

Front. Cell Dev. Biol., 2025, 13
DOI: 10.3389/fcell.2025.1529901

C3AR1 may aggravate diabetic nephropathy by mediating oxidative stress via ITGB2 regulation in renal tubular epithelial cells

Alex Abura, Shan Gao and Shinsuke Yuasa

PLoS One, 2025, 20, e0331900
DOI: 10.1371/journal.pone.0331900

Mitochondrial Dynamics in Diabetic Kidney Disease: Underlying Mechanisms and Novel Therapeutics

Nan Shao, Jinghan Wang, Jiaoying Liu, Junhua Zhang, Bin Zhang, Xiaobo Sun and Xiaoqiu Liu

IJMS, 2026, 27, 2429
DOI: 10.3390/ijms27052429

Rhizoma Dioscoreae Nipponicae Relieves Asthma by Inducing the Ferroptosis of Eosinophils and Inhibiting the p38 MAPK Signaling Pathway

Libin Jiang, Liying Xu, Huazuo Liu, Hanwen Chen and Weiyi Wang

Crit Rev Immunol, 2024, 44, 77
DOI: 10.1615/CritRevImmunol.2023050922

Dioscin exerts nephroprotective effects by attenuating oxidative stress and necroptosis-induced inflammation

Shuang Wang, Zhuofan Lei, Shan Chen, Anqi Xiang, Yanlu Zou and Yun Liu

International Immunopharmacology, 2024, 140, 112885
DOI: 10.1016/j.intimp.2024.112885

mTOR-mediated nutrient sensing and oxidative stress pathways regulate autophagy: a key mechanism for traditional Chinese medicine to improve diabetic kidney disease

Liu Li, Junju Zou, Tongyi Zhou, Xiu Liu, Danni Tan, Qin Xiang and Rong Yu

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1578400

Autophagy, Pyroptosis and Ferroptosis are Rising Stars in the Pathogenesis of Diabetic Nephropathy

Xiudan Li, Lifeng Gao, Xuyang Li, Jingdong Xia, Yurong Pan and Chunying Bai

DMSO, 2024, Volume 17, 1289
DOI: 10.2147/DMSO.S450695

NOX4-mediated oxidative stress in diabetic complications: Potential of natural products

Sachin Sharma, Ashwani Mittal and Manjusha Choudhary

Pharmacological Research - Natural Products, 2026, 10, 100515
DOI: 10.1016/j.prenap.2026.100515

Integrating network pharmacology and experimental validation to decipher the pharmacological mechanism of DXXK in treating diabetic kidney injury

Chenxu Zhang, Zhangxin Ji, Na Xu, Jingjing Yuan, Wen Zeng, Yadong Wang, Qing He, Jiaxing Dong, Xinyu Zhang, Dongmei Yang, Wei Jiang, Yibo Yan, Wencui Shang, Jun Chu and Quangen Chu

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-73642-y

Dioscin ameliorates silica-aggravated systemic lupus erythematosus via suppressing apoptosis and improving LC3-associated phagocytosis in MRL/lpr mice

Peng Zhang, Xue Lei, Liang Ou, Yuxing Cheng, Qianru Miao, Chao Li and Ying Chen

International Immunopharmacology, 2023, 116, 109814
DOI: 10.1016/j.intimp.2023.109814

Chinese botanical drugs targeting mitophagy to alleviate diabetic kidney disease, a comprehensive review

Leilei Ma, Jing Li, Xiaotian Zhang, Wei Zhang, Chen Jiang, Bo Yang and Hongtao Yang

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1360179

Mitochondrial fission protein 1 in the regulation of mitochondrial quality control: A cancer perspective

Chao Wei, Xiaoling Yuan, Xiaoli Liu, Jia Feng, Miao Song, Xuexue Liu, Jiahong Zhou and Jinbo Liu

Interdisciplinary Medicine, 2025, 3
DOI: 10.1002/INMD.20240033

AMPK-endoplasmic reticulum stress axis contributes to lipopolysaccharide-caused mitochondrial dysfunction by regulating mitochondria-associated membrane function in bovine hepatocytes

Wan Xie, Mengru Chen, Juan J. Loor, Xiaokun Song, Nana Ma, Shendong Zhou, Hongzhu Zhang, Guangjun Chang and Xiangzhen Shen

Journal of Dairy Science, 2023, 106, 5146
DOI: 10.3168/jds.2022-22879