Pyrogallol, Corilagin and Chebulagic acid target the “fuzzy coat” of alpha-synuclein to inhibit the fibrillization of the protein

Mandar Bopardikar, Sri Rama Koti Ainavarapu and Ramakrishna V. Hosur

RSC Adv., 2022, 12, 35770
DOI: 10.1039/D2RA04358K

Sequence-based identification of amyloidogenic β-hairpins reveals a prostatic acid phosphatase fragment promoting semen amyloid formation

Laetitia F. Heid, Emil Dandanell Agerschou, Asuka A. Orr, Tatsiana Kupreichyk, Walfried Schneider, Michael M. Wördehoff, Melanie Schwarten, Dieter Willbold, Phanourios Tamamis, Matthias Stoldt and Wolfgang Hoyer

Computational and Structural Biotechnology Journal, 2024, 23, 417
DOI: 10.1016/j.csbj.2023.12.023

Rationally designed amyloid inhibitors based on amyloid-related structural studies

Jinjian Hu, Yufen Zhao and Yanmei Li

Chinese Chemical Letters, 2023, 34, 107623
DOI: 10.1016/j.cclet.2022.06.046

A RaPID Macrocyclic Peptide That Inhibits the Formation of α‐Synuclein Amyloid Fibrils

Tatsuya Ikenoue, Miki Oono, Masatomo So, Hodaka Yamakado, Toshiaki Arata, Ryosuke Takahashi, Yasushi Kawata and Hiroaki Suga

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202300320

Fibril core regions in engineered α-synuclein dimer are crucial for blocking of fibril elongation

Celina M. Schulz, Anne Pfitzer and Wolfgang Hoyer

BBA Advances, 2023, 4, 100110
DOI: 10.1016/j.bbadva.2023.100110

Research Progress of α-Synuclein Aggregation Inhibitors for Potential Parkinson’s Disease Treatment

Iqra Kalsoom, Yuanhao Wang, Bo Li and Hongliang Wen

MRMC, 2023, 23, 1959
DOI: 10.2174/1389557523666230517163501

Rationally Designed Protein-Based Inhibitor of α-Synuclein Fibrillization in Cells

Anastasiia Priss, Kseniia Afitska, Maksym Galkin, Dmytro A. Yushchenko and Volodymyr V. Shvadchak

J. Med. Chem., 2021, 64, 6827
DOI: 10.1021/acs.jmedchem.1c00086

Nucleation of α-Synuclein Amyloid Fibrils Induced by Cross-Interaction with β-Hairpin Peptides Derived from Immunoglobulin Light Chains

Laetitia F. Heid, Tatsiana Kupreichyk, Marie P. Schützmann, Walfried Schneider, Matthias Stoldt and Wolfgang Hoyer

IJMS, 2023, 24, 16132
DOI: 10.3390/ijms242216132

Dopamine-Induced Oligomers of α-Synuclein Inhibit Amyloid Fibril Growth and Show No Toxicity

Maksym Galkin, Oleksandra Topcheva, Anastasiia Priss, Tatiana Borisova and Volodymyr V. Shvadchak

ACS Chem. Neurosci., 2023, 14, 2027
DOI: 10.1021/acschemneuro.2c00815

Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo

Anne K. Braczynski, Marc Sevenich, Ian Gering, Tatsiana Kupreichyk, Emil D. Agerschou, Yannick Kronimus, Pardes Habib, Matthias Stoldt, Dieter Willbold, Jörg B. Schulz, Jan-Philipp Bach, Björn H. Falkenburger and Wolfgang Hoyer

Biomolecules, 2022, 12, 469
DOI: 10.3390/biom12030469

Molecular Mechanisms of Inhibition of Protein Amyloid Fibril Formation: Evidence and Perspectives Based on Kinetic Models

Igor Sedov and Diliara Khaibrakhmanova

IJMS, 2022, 23, 13428
DOI: 10.3390/ijms232113428

Disordered regions of inhibitor-bound α-synuclein suppress seed-induced fibril nucleation in cells

Celina M. Schulz, Emil D. Agerschou, Luis Gardon, Miriam Alexander, Matthias Stoldt, Henrike Heise, Gültekin Tamgüney and Wolfgang Hoyer

Cell Reports Physical Science, 2024, 5, 102180
DOI: 10.1016/j.xcrp.2024.102180

β-Turn exchanges in the α-synuclein segment 44-TKEG-47 reveal high sequence fidelity requirements of amyloid fibril elongation

Emil Dandanell Agerschou, Marie P. Schützmann, Nikolas Reppert, Michael M. Wördehoff, Hamed Shaykhalishahi, Alexander K. Buell and Wolfgang Hoyer

Biophysical Chemistry, 2021, 269, 106519
DOI: 10.1016/j.bpc.2020.106519

FRET‐based assay for intracellular evaluation of α‐synuclein aggregation inhibitors

Maksym Galkin, Anastasiia Priss, Oleksandra Topcheva, Dmytro A. Yushchenko and Volodymyr V. Shvadchak

Journal of Neurochemistry, 2021, 159, 901
DOI: 10.1111/jnc.15528

Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases

Dillon J. Rinauro, Fabrizio Chiti, Michele Vendruscolo and Ryan Limbocker

Mol Neurodegeneration, 2024, 19
DOI: 10.1186/s13024-023-00651-2

Navigating α‐Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets

Maksym Galkin, Anastasiia Priss, Yevhenii Kyriukha and Volodymyr Shvadchak

The Chemical Record, 2024, 24
DOI: 10.1002/tcr.202300282