Recent advances in microwave-assisted synthesis of triazoles and their derivatives: a green approach toward sustainable development methods

Suman Swami, Neelam Sharma, Garvit Sharma and Rahul Shrivastava

RSC Adv., 2025, 15, 2361
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Green synthesis of 1,4-disubstituted 1,2,3-triazoles: a sustainable approach

Sachin Kumar, Bajrang Lal and Ram Kumar Tittal

Green Chem., 2024, 26, 1725
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Recent developments on microwave-assisted organic synthesis of nitrogen- and oxygen-containing preferred heterocyclic scaffolds

Ghanshyam Tiwari, Ashish Khanna, Vinay Kumar Mishra and Ram Sagar

RSC Adv., 2023, 13, 32858
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Click synthesis of novel 6-((1H-1,2,3-triazol-4-yl)methyl)-6H-indolo[2,3-b]quinoxalines for in vitro anticancer evaluation and docking studies

Tamer El Malah, Ahmed A. El-Rashedy, Mohamed Ibrahim Hegab, Hanem M. Awad and Ahmed Hussien Shamroukh

New J. Chem., 2024, 48, 11064
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Novel isatin–triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies

Alia Mushtaq, Rabbia Asif, Waqar Ahmed Humayun and Muhammad Moazzam Naseer

RSC Adv., 2024, 14, 14051
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Synthesis and antibiofilm activity of 1,2,3-triazole-pyridine hybrids against methicillin-resistant Staphylococcus aureus (MRSA)

Tamer El Malah, Hanan A. Soliman, Bahaa A. Hemdan, Randa E. Abdel Mageid and Hany F. Nour

New J. Chem., 2021, 45, 10822
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Synthesis, in vitro antimicrobial evaluation, and molecular docking studies of new isatin-1,2,3-triazole hybrids

Tamer El Malah, Hanaa Farag, Bahaa A. Hemdan, Randa E. Abdel Mageid, Mohamad T. Abdelrahman, May A. El-Manawaty and Hany F. Nour

Journal of Molecular Structure, 2022, 1250, 131855
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Anticancer Activity and Molecular Docking of 1,2,3-Triazole Hybrids of Phenol and 4-Methoxy-2-methylphenyl: Synthesis via Click Chemistry

A. K. Alshamari

Russ J Org Chem, 2023, 59, 455
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Unlocking bacterial defense: Exploring the potent inhibition of NorA efflux pump by coumarin derivatives in Staphylococcus aureus

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One-pot three-component condensation for the synthesis of 2,4,6-triarylpyridines and evaluation of their antimicrobial activity

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J Chem Sci, 2021, 133
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Synthesis of Some 1,2,3-triazole-bridged glycosides with benzoquniline-3-carbonitriles via click chemistry for anticancer, and docking evaluation

Tamer El Malah, Mohamed N. El-Bayaa, Mohamad Taha Abdelrahman, Hanem M. Awad and Hanan A. Soliman

Journal of Molecular Structure, 2025, 1321, 139681
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Synthesis of 1,2,3‐Triazole‐Containing 2,3‐Dihydrofuran Derivatives, Evaluation of Anticancer Activity and Molecular Docking Studies

Anil Kumar Sabhavath, Sarasija Madderla, Ravinder Dharavath, Vishnu Thumma, Gugulothu Thara, Srinivas Gundu and Ashok Dongamanti

ChemistrySelect, 2022, 7
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Click chemistry beyond metal‐catalyzed cycloaddition as a remarkable tool for green chemical synthesis of antifungal medications

Azar Tahghighi and Parisa Azerang

Chem Biol Drug Des, 2024, 103
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Microwave assisted synthesis of 4‐methyl‐3‐arylpyrano[2,3‐f]chromen‐2(8H)‐one derivatives, evaluation of antiproliferative, and antimicrobial activities

Ravinder Dharavath, Madderla Sarasija, Makthal Ram Reddy, Nagaraju Nalaparaju, Ramakrishna Katta and Dongamanti Ashok

Journal of Heterocyclic Chem, 2020, 57, 3943
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Microwave assisted synthesis of N‐substituted acridine‐1,8‐dione derivatives: Evaluation of antimicrobial activity

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Journal of Heterocyclic Chem, 2022, 59, 1180
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Nanometals: As click catalysts for 1,4-triazole cycloaddition (2020-till date)

Keshav Taruneshwar Jha, Chahat and Pooja A. Chawla

Sustainable Chemistry and Pharmacy, 2023, 35, 101195
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Synthesis of new 1,2,3-triazole-linked pyrimidines by click reaction

Forough Cheldavi, Mohammad Bakherad, Ali Keivanloo and Mohsen Nikpour

Phosphorus, Sulfur, and Silicon and the Related Elements, 2024, 199, 725
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Microwave Assisted Synthesis of Flavonoid Based 1,2,3-Triazole and Isoxazole Derivatives, Their Antibacterial, Antioxidant, and Anticancer Activities

Dongamanti Ashok, Gugulothu Thara, Ravinder Dharavath, Bhukya Kirankumar, Madderla Sarasija and Bhukya Bhima

Russ J Gen Chem, 2022, 92, 718
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Design and synthesis of novel xanthone-thiazole hybrid derivatives as potent anti-inflammatory agent

Lokman Ali Ahmed, Babita Deka, Hiyashree Sharmah, Pooja Patowary, Bhargab Jyoti Sahariah and Apurba Talukdar

Computational Biology and Chemistry, 2025, 119, 108523
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A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)

Mahrokh Marzi, Mojtaba Farjam, Zahra Kazeminejad, Abolfazl Shiroudi, Amin Kouhpayeh, Elham Zarenezhad and Vinod Kumar Tiwari

Journal of Chemistry, 2022, 2022, 1
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Contemporary advances of cyclic molecules proposed for inflammation

Kumari Neha and Sharad Wakode

European Journal of Medicinal Chemistry, 2021, 221, 113493
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Coumarin Triazoles as Potential Antimicrobial Agents

Siddappa A. Patil, Aravind R. Nesaragi, Raúl R. Rodríguez-Berrios, Sydney M. Hampton, Alejandro Bugarin and Shivaputra A. Patil

Antibiotics, 2023, 12, 160
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Review on Contemporary Synthetic Recipes to Access Versatile Coumarin Heterocycles

Suliphuldevara Mathada Basavarajaiah, Nagesh Gunavanthrao Yernale, Munianjinappa Punith Kumar and Budimath Rakesh

Polycyclic Aromatic Compounds, 2024, 44, 3576
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Microwave-assisted Amination Reactions: An Overview

Sankaran Radhika, Mohan Neetha, Thaipparambil Aneeja and Gopinathan Anilkumar

COC, 2020, 24, 2235
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Benzothiazole-tethered 1,2,3-triazoles: Synthesis, antimicrobial, antioxidant, and molecular docking studies

Tamer El Malah, Mohamed I. Hegab, Hassan M. Awad, Mohamad T. Abdelrahman, Farouk M.E. Abdel-Megeid, Ahmed H. Shamroukh, Randa E. Abdel Mageid and Hany F. Nour

Journal of Molecular Structure, 2022, 1266, 133417
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Recent advances in the microwave- and ultrasound-assisted green synthesis of coumarin-heterocycles

Biplob Borah, Kartikey Dhar Dwivedi, Bhupender Kumar and L. Raju Chowhan

Arabian Journal of Chemistry, 2022, 15, 103654
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Emerging Approaches for Synthesis of 1,2,3-Triazole Derivatives. A Review

Shivangi Jaiswal, Meenu Devi, Neha Sharma, Komal Rathi, Jaya Dwivedi and Swapnil Sharma

Organic Preparations and Procedures International, 2022, 54, 387
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Development of Novel Indole and Coumarin Derivatives as Antibacterial Agents That Target Histidine Kinase in S. aureus

Lisha K. Poonacha, Rashmi Ramesh, Akshay Ravish, Arunkumar Mohan, Pradeep M. Uppar, Prashant K. Metri, Nanjunda Swamy Shivananju, Santosh L. Gaonkar, Shubha Gopal, Alexey Yu Sukhorukov, Vijay Pandey, Priya Babu Shubha and Basappa Basappa

Applied Microbiology, 2023, 3, 1214
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Enhanced in vivo antimalarial activity of artemether by clotrimazole against drug-sensitive and resistant Plasmodium berghei

Franklin C. Kenechukwu , Mumuni A. Momoh , Wilfred I. Ugwuoke , Daniel O. Nnamani , Joy I. Nwobodo , Jude E. Ogbonna , Ezichim F. Nzekwe , Linda C. Nweke , Mary U. Obila , Tochukwu Odoh , Bonaventure A. Odo, Chinekwu S. Nwagwu , Celestine C. Anikwe , Joshua C. Okachi and Anthony A. Attama

J. Drug Delivery Ther., 2025, 15, 1
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Click Chemistry in Natural Product Modification

Xiang Zhang, Shuning Zhang, Songfeng Zhao, Xuan Wang, Bo Liu and Hongtao Xu

Front. Chem., 2021, 9
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Microwave-assisted synthesis and evaluation of their antiproliferative, antimicrobial, activities and DNA Binding studies of (3-Methyl-7H-furo[2,3-f]chromen-2-yl)(aryl)methanones

Ravinder Dharavath, M. Sarasija, M. Ram Reddy, K. Naga Prathima, N. Nagarju, K. Ramakrishna, D. Ashok and Sreenu Daravath

Med Chem Res, 2022, 31, 993
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Design, Synthesis and In Silico Molecular Docking Evaluation of New Series of 1,2,3‐Triazole Derivatives as Potent Antimicrobial Agents

Venkatesan Vellaiyan, Honnappa Nagarajaiah, Adamshafi Shaik, Pilli V. V. N Kishore and Shravan Kumar Gunda

ChemistrySelect, 2024, 9
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Click Chemistry-Based Synthesis, Characterization, and DFT Studies of Some Novel 2-Acetylphenoxy-1,2,3-Triazoles

Tamer El Malah, Hanaa Farag, Mohamed A. Abdelati and Mohamed I. Hegab

Polycyclic Aromatic Compounds, 2024, 44, 5070
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Design and Click Synthesis of Novel 1- Substituted-4-(3,4-Dimethoxyphenyl)-1 H -1,2,3-Triazole Hybrids for Anticancer Evaluation and Molecular Docking

Tamer El Malah, Hanaa Farag, Hanem Mohamed Awad, Mohamad Taha Abdelrahman and Ahmed Hussien Shamroukh

Polycyclic Aromatic Compounds, 2023, 43, 7547
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Microwave-assisted protocol towards synthesis of heterocyclic molecules: a comparative analysis with conventional synthetic methodologies (years 2019–2023): a review

Iffat Almas, Ayesha Malik, Nasir Rasool, Aqsa Kanwal, Tahira Khalid and Hamna Nawaz

Mol Divers, 2025, 29, 2717
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Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance

Harish C. Upadhyay

CTMC, 2021, 21, 737
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Click-coupling synthesis of new 1-phenacyl-4-substituted 1,2,3-triazoles

Saloomeh Maleki, Mohammad Bakherad, Hossein Nasr-Isfahani, Esmaiel Dehghanibavani and Leila Kamrani Tamardash

Monatsh Chem, 2025, 156, 655
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Microwave-assisted synthesis of (6-((1-(4-aminophenyl)-1H-1,2,3-triazol-4-yl)methoxy)substituted benzofuran-2-yl)(phenyl)methanones, evaluation of in vitro anticancer, antimicrobial activities and molecular docking on COVID-19

Ravinder Dharavath, M. Sarasija, K.N. Prathima, M. Ram Reddy, Shyam Panga, Vishnu Thumma and D. Ashok

Results in Chemistry, 2022, 4, 100628
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Synthesis, Antimicrobial Evaluation, and In Silico Molecular Docking Studies of Chalcone-Based 1,2,3-Triazoles

Ch. Prasad, P. Nagesh, Ch. Kishan, V. Murali Krishna, A. Balaswamy, V. Manga, B. Prashanth and Y. Aparna

Russ J Gen Chem, 2023, 93, 1162
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Design and Synthesis of Novel 1,2,3-Triazole Levonorgestrel Derivatives via Click Chemistry. Anticancer Activity and Molecular Docking

A. K. Alshamari

Russ J Org Chem, 2022, 58, 1878
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Synthesis of Isatin-Schiff Base and 1,2,3-Triazole Hybrids as Anti-SARS-CoV-2 Agents: DFT, Molecular Docking, and ADMET Studies

Tamer El Malah, Ahmed A. El-Rashedy, Omnia Kutkat, Rabeh A. El Shesheny, Aymn E. Rashad and Ahmed H. Shamroukh

Polycyclic Aromatic Compounds, 2025, 1
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The Emerging Landscape of Tubercular Targets: A Medicinal Chemistry Approach

Baji Baba Shaik, Kimeshni Moodley, Safiyah Ghumran, Muhammad D. Bala, Parvesh Singh and Rajshekhar Karpoormath

Medicinal Research Reviews, 2025, 45, 1077
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Microwave‐Assisted Synthesis of Bis‐1,2,3‐Triazole‐Based Benzophenones, In Vitro Antimicrobial Activity, and Molecular Docking Studies

Ravinder Dharavath, Ravila Meena, Amit Ranjan and Vishnu Thumma

Chemistry & Biodiversity, 2025, 22
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An updated review on 1,2,3-/1,2,4-triazoles: synthesis and diverse range of biological potential

Anirudh Pratap Singh Raman, Mohd. Aslam, Amardeep Awasthi, Anas Ansari, Pallavi Jain, Kashmiri Lal, Indra Bahadur, Prashant Singh and Kamlesh Kumari

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Coumarins: Chemical Synthesis, Properties and Applications

Safa Elmusa, Muna Elmusa, Benan Elmusa and Rahmi Kasımoğulları

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Environmentally benign synthesis of 1,4-disubstituted 1,2,3-triazoles: Recent advances and future prospectives

Lokesh Kumar, Riya Bajaj, Jyoti Sangwan, Kashmiri Lal and Jayant Sindhu

Sustainable Chemistry One World, 2025, 5, 100051
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Application of triazoles in the structural modification of natural products

Hong-Yan Guo, Zheng-Ai Chen, Qing-Kun Shen and Zhe-Shan Quan

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36, 1115
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Ultra speed synthesis of carbon quantum dots (GCQDs) and Gold (GCQDs-Au) Nano composites, for the Catalytic reduction of MG Dye, Microbial activity and stability studies

Yaku Gugulothu, Paluri Anjaiah, M. Prashanthi and Umesh Kumar Utkoor

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Synthesis, and antimicrobial activity of some novel 1, 2, 3-triazol-4-yl conjugated indolin-2-one derivatives

S. Shahjahan, Narjis Fatima, Md. Farveen, Ayub Shaik, Dasari Ayodhya and Ahmed Kamal

J IRAN CHEM SOC, 2025, 22, 997
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Design and synthesis of new coumarin-1,2,3-triazole hybrids as new antidiabetic agents: In vitro α-amylase, α-glucosidase inhibition, anti-inflammatory, and docking study

Vinayaka Chandrappa Barangi, Lokesh Anand Shastri, Prakasha Kothathi Chowdegowda, Rohini Sangappanavar, Karthik Inamdar, Nagarjuna Prakash Dalbanjan, Delicia Avilla Barretto and Vinay Sunagar

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An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Francesca Annunziata, Cecilia Pinna, Sabrina Dallavalle, Lucia Tamborini and Andrea Pinto

IJMS, 2020, 21, 4618
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An overview of microwave assisted cyanation reactions

Jaleel Fairoosa, Salahudeen Shamna, Mohan Neetha and Gopinathan Anilkumar

Applied Organom Chemis, 2021, 35
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Synthesis and anticancer activity of novel coumarin-stilbene hybrids with different hydrocarbon chains as linkers

Lamya A. Al-lehaib, Ehab M. M. Ali, Khalid O. Al-Footy and Reda M. El-Shishtawy

Med Chem Res, 2024, 33, 764
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Coumarin-indole hybrids: synthesis, characterization & anti-inflammatory evaluation

Hiyashree Sharmah, Pooja Patowary, Lokman Ali Ahmed, Babita Deka, Abu Saif Mustaque and Bhargab Jyoti Sahariah

Journal of the Indian Chemical Society, 2025, 102, 102018
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Cascade chemo-enzymatic synthesis of disubstituted 1,2,3-triazole derivatives: Enhancing the activity by immobilized enzyme on g-C3N4

Zeinab Piraman and Hamid R. Kalhor

Molecular Catalysis, 2025, 585, 115361
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Synthesis and biological evaluation of novel 2‐arylquinoline‐3‐fused thiazolo[2,3‐c]1,2,4‐triazole heterocycles as potential antiproliferative and antimicrobial agents

Ramulu Dhanavath, Ravinder Dharavath, Devender Kothula, Sampath Bitla, Gugulothu Yaku, Saritha Birdaraju, Muralidhar Reddy Puchakayala and Krishnam Raju Atcha

Journal of Heterocyclic Chem, 2022, 59, 1198
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Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity

Zaozao Xiao, Yuang Gu, Hewei Dong, Bo Liu, Weiwei Jin, Jie Li, Peixiang Ma, Hongtao Xu and Wei Hou

European Journal of Medicinal Chemistry Reports, 2023, 9, 100113
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Coumarin Derivatives: Microwave Synthesis and Biological Properties—A Review

Wissam Habibi, Soumaya Talbi, Salha Hamri, Abderrafia Hafid and Mostafa Khouili

Journal of Heterocyclic Chem, 2024, 61, 2070
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3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade

Maria J. Matos, Eugenio Uriarte and Lourdes Santana

Molecules, 2021, 26, 6755
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Bis 1, 2, 3‐ Triazoles Linked Deoxybenzoin Hybrids as Antimicrobial Agents: Synthesis, In Vitro and In Silico Screening

Shalini Aitha, Vishnu Thumma, Shankaraiah Ambala, Raghavender Matta, Shyam Panga and Jalapathi Pochampally

ChemistrySelect, 2023, 8
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Microwave-Assisted Synthesis of Heterocyclic Scaffolds

Sanjeev Kumar, Anand Maurya and Alka Agarwal

SynOpen, 2024, 08, 138
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Mitigating Antimicrobial Resistance through Strategic Design of Multimodal Antibacterial Agents Based on 1,2,3-Triazole with Click Chemistry

Shabin N. Chathangad, Vishnu N. Vijayan, Jissy Anna George and Sushabhan Sadhukhan

ACS Bio Med Chem Au, 2025, 5, 486
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Click synthesis, anticancer and molecular docking evaluation of some hexahydro-6H-indolo[2,3-b]quinoxalines incorporated triazole moiety

Tamer El Malah, Randa El-Sayed Abd El-Mageid, Ahmed Hussien Shamroukh, Aymn Elsayed Rashad, Ahmed A. El-Rashedy, Hanem Mohamed Awad, Farouk Mohamed E. Abdel-Megeid and Mohamed Ibrahim Hegab

Journal of Molecular Structure, 2024, 1303, 137573
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The Riveting Chemistry of Poly‐aza‐heterocycles Employing Microwave Technique: A Decade Review

Jay Prakash Soni, Swanand Vinayak Joshi, Krishna Sowjanya Chemitikanti and Nagula Shankaraiah

Eur J Org Chem, 2021, 2021, 1476
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Microwave accelerated green approach for tailored 1,2,3–triazoles via CuAAC

Nancy George, Gurleen Singh, Riddima Singh, Gurjaspreet Singh, Anita Devi, Harminder Singh, Gurpreet Kaur and Jandeep Singh

Sustainable Chemistry and Pharmacy, 2022, 30, 100824
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Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery

Rameshwar S. Cheke, Harun M. Patel, Vaishali M. Patil, Iqrar Ahmad Ansari, Jaya P. Ambhore, Sachin D. Shinde, Adel Kadri, Mejdi Snoussi, Mohd Adnan, Prashant S. Kharkar, Visweswara Rao Pasupuleti and Prashant K. Deshmukh

Antibiotics, 2022, 11, 566
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