Trends of antimalarial marine natural products: progresses, challenges and opportunities

Yang Hai, Zi-Mu Cai, Peng-Jie Li, Mei-Yan Wei, Chang-Yun Wang, Yu-Cheng Gu and Chang-Lun Shao

Nat. Prod. Rep., 2022, 39, 969
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Future antimalarials fromArtemisia? A rationale for natural product mining against drug-refractoryPlasmodiumstages

Alexandre Maciuk, Dominique Mazier and Romain Duval

Nat. Prod. Rep., 2023, 40, 1130
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The emergence of the C–H functionalization strategy in medicinal chemistry and drug discovery

Ranjan Jana, Hasina Mamataj Begam and Enakshi Dinda

Chem. Commun., 2021, 57, 10842
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4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives

Prisca Lagardère, Romain Mustière, Nadia Amanzougaghene, Sébastien Hutter, Jean-François Franetich, Nadine Azas, Patrice Vanelle, Pierre Verhaeghe, Nicolas Primas, Dominique Mazier, Nicolas Masurier and Vincent Lisowski

Pharmaceuticals, 2022, 15, 820
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Exosomes: A novel insight into traditional Chinese medicine

Chao Mo, Jie Zhao, Jingyan Liang, Huiling Wang, Yu Chen and Guodong Huang

Front. Pharmacol., 2022, 13
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Indoloquinoline Alkaloids as Antimalarials: Advances, Challenges, and Opportunities

Prakash T. Parvatkar, Khaly Diagne, Yingzhao Zhao and Roman Manetsch

ChemMedChem, 2024
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Structural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agents

Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han and Wanjoo Chun

Malar J, 2025, 24
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Design, Synthesis, Antitumor, and Antiplasmodial Evaluation of New 7-Chloroquinoline–Benzimidazole Hybrids

Luka Krstulović, Vesna Rastija, Lais Pessanha de Carvalho, Jana Held, Zrinka Rajić, Zorislava Živković, Miroslav Bajić and Ljubica Glavaš-Obrovac

Molecules, 2024, 29, 2997
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A progress report in advancements of heterocyclic compounds as novel antimalarial agents over the last 5 years

Sumit Tahlan, Sucheta Singh, Meenakshi Kaira, Hrithik Dey and Kailash C. Pandey

European Journal of Medicinal Chemistry, 2025, 289, 117393
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Emerging nanotechnology-driven drug delivery solutions for malaria: Addressing drug resistance and improving therapeutic success

Anuradha Mishra, Firdaus Qamar, Kudsiya Ashrafi, Saman Fatima, Mohammed Samim, Asif Mohmmed and Malik Zainul Abdin

International Journal of Pharmaceutics, 2025, 670, 125163
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Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8+ T cells in cerebral malaria

Yi Wang, Yan Shen, Jiao Liang, Shubiao Wang, Yuxiao Huang, Qinghao Zhu, Xizhi Zhang, Kangjie Yu, Guodong Tong, Chao Yang, Yinghui Li, Jun Wang and Ya Zhao

J Neuroinflammation, 2024, 21
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Phytochemical and pharmacological properties of Xanthium species: a review

Jingwen Wang, Dongsheng Wang, Bingrong Wu, Jing Han and Ninghua Tan

Phytochem Rev, 2025, 24, 773
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Synthesis and antiplasmodial activity of regioisomers and epimers of second-generation dual acting ivermectin hybrids

Lovepreet Singh, Diana Fontinha, Denise Francisco, Miguel Prudêncio and Kamaljit Singh

Sci Rep, 2022, 12
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Application Prospects of Triphenylphosphine-Based Mitochondria-Targeted Cancer Therapy

Xiaoxia Cheng, Dong Feng, Junyu Lv, Xiaoman Cui, Yichen Wang, Qun Wang and Lei Zhang

Cancers, 2023, 15, 666
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Endoperoxidases in biosynthesis of endoperoxide bonds

Shaoshan Zhang, Bin He, Axiang Qu-Bie, Min Li, Mengting Luo, Mingkang Feng, Xinjia Yan, Huachun Sheng, Wenbing Li, Yan Gou and Yuan Liu

International Journal of Biological Macromolecules, 2024, 282, 136806
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Lecaniodiscus cupanioides leaf extract attenuates Plasmodium berghei-induced malaria infection in albino mice via modulation of serum biochemical and hematological markers

Aderonke A. Aderinola, Jane I. Ejiofor, Luqman O. Ogunjimi, Abdullahi A. Murtala, Oyinloye E. Oladapo and Farouk A. Oladoja

Pharmacological Research - Natural Products, 2025, 7, 100257
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Fluorene‐Chloroquine Hybrids: Synthesis, in vitro Antiplasmodial Activity, and Inhibition of Heme Detoxification Machinery of Plasmodium falciparum

Parth, Navpreet Kaur, Constance Korkor, Shaikh M. Mobin, Kelly Chibale and Kamaljit Singh

ChemMedChem, 2022, 17
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Total synthesis of natural products containing bicyclo[n.2.2] ring systems

Bao-Long Hou, Junyang Liu, Chuang Qiao and Chuang-Chuang Li

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Bridging the gaps: Prioritizing research strategies for enhanced malaria control and elimination

Rashed Alghamdi

Journal of Vector Borne Diseases, 2025, 62, 24
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Anti-plasmodial and toxicological effects of BEEMAR - a natural formulation of harnessed honeycomb bioactive compounds suspended in enhanced marine plasma

Samuel Adjei, Richard Obeng-Kyeremeh, Isaac Ackah, Constance Agbemelo-Tsomafo, Daniel Amoah, Stephen Asante Obeng, Frederick Asamoah, Susan Damanka, Kwabena Owusu Danquah, Michael Preko Ntiri, Monia Enyonam Honyo, Isaac Joe Erskine, Festus Kojo Acquah, Linda Eva Amoah and Kwadwo Asamoah Kusi

Front. Nat. Prod., 2025, 4
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In vitro and in vivo antiplasmodial activity of a synthetic dihydroartemisinin–eosin B hybrid

Hajar Karimi Askarani, Azar Tahghighi, Mahdieh Ahmadpoor and Zahra Zamani

Naunyn-Schmiedeberg's Arch Pharmacol, 2024, 397, 4013
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An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes

Monika Shukla, Komal Rathi, Mohammad Hassam, Dinesh Kumar Yadav, Manvika Karnatak, Varun Rawat and Ved Prakash Verma

Medicinal Research Reviews, 2024, 44, 66
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Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

Peng Tang, Tianze Shen, Hairong Wang, Ruihan Zhang, Xingjie Zhang, Xiaoli Li and Weilie Xiao

Biomedicine & Pharmacotherapy, 2023, 164, 114955
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Unsupervised machine learning, QSAR modelling and web tool development for streamlining the lead identification process of antimalarial flavonoids

J.H. Zothantluanga, D. Chetia, S. Rajkhowa and A.K. Umar

SAR and QSAR in Environmental Research, 2023, 34, 117
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The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria

Alexandra Bourgeois, Juliana Aline Souza Lemos, Stéphanie Roucheray, Audrey Sergerie and Dave Richard

Infectious Disease Reports, 2024, 16, 543
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Traditional Chinese medicine trade among RCEP countries: structural characteristics and determinants

Yue Fang, Meng Xue Tang and Xu Liu

Front. Public Health, 2025, 12
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Prospecting Pharmacologically Active Biocompounds from the Amazon Rainforest: In Vitro Approaches, Mechanisms of Action Based on Chemical Structure, and Perspectives on Human Therapeutic Use

Andryo O. de Almada-Vilhena, Oscar V. M. dos Santos, Milla de A. Machado, Cleusa Y. Nagamachi and Julio C. Pieczarka

Pharmaceuticals, 2024, 17, 1449
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