Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems

Alisa Ugodnikov, Henrik Persson and Craig A. Simmons

Lab Chip, 2024, 24, 3199
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Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications

Kristin Fabre, Brian Berridge, William R. Proctor, Sherry Ralston, Yvonne Will, Szczepan W. Baran, Gorm Yoder and Terry R. Van Vleet

Lab Chip, 2020, 20, 1049
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Microfluidic arrays of dermal spheroids: a screening platform for active ingredients of skincare products

Zhengkun Chen, Sina Kheiri, Albert Gevorkian, Edmond W. K. Young, Valerie Andre, Ted Deisenroth and Eugenia Kumacheva

Lab Chip, 2021, 21, 3952
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The frontline of alternatives to animal testing: novel in vitro skin model application in drug development and evaluation

He Zhao, Zhaozeng Chen, Xingchen Kang, Bo Yang, Peihua Luo, Hui Li and Qiaojun He

Toxicological Sciences, 2023, 196, 152
DOI: 10.1093/toxsci/kfad093

Advances in tissue engineering and biofabrication for in vitro skin modeling

Sarah C. Wistner, Layla Rashad and Gymama Slaughter

Bioprinting, 2023, 35, e00306
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Microphysiological Systems: Stakeholder Challenges to Adoption in Drug Development

Passley Hargrove-Grimes, Lucie A. Low and Danilo A. Tagle

Cells Tissues Organs, 2022, 211, 269
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Complex in vitro models positioned for impact to drug testing in pharma: a review

Serah Kang, Eugene C Chen, Helen Cifuentes, Julia Y Co, Gabrielle Cole, Jessica Graham, Rebecca Hsia, Tomomi Kiyota, Jessica A Klein, Katharina T Kroll, Lenitza M Nieves Lopez, Leah M Norona, Heshan Peiris, Ratnakar Potla, Monica Romero-Lopez, Julien G Roth, Min Tseng, Aaron M Fullerton and Kimberly A Homan

Biofabrication, 2024, 16, 042006
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In vitro 3D skin culture and its sustainability in toxicology: a narrative review

Syafira Masri, Mh Busra Fauzi, Nor Fadilah Rajab, Wing-Hin Lee, Diana Atiqah Zainal Abidin and Ee Ling Siew

Artificial Cells, Nanomedicine, and Biotechnology, 2024, 52, 476
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The Combination of Cell Cultured Technology and In Silico Model to Inform the Drug Development

Zhengying Zhou, Jinwei Zhu, Muhan Jiang, Lan Sang, Kun Hao and Hua He

Pharmaceutics, 2021, 13, 704
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Organs-on-chips: into the next decade

Lucie A. Low, Christine Mummery, Brian R. Berridge, Christopher P. Austin and Danilo A. Tagle

Nat Rev Drug Discov, 2021, 20, 345
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Key Properties for the Toxicity Classification of Chemicals: A Comparison of the REACH Regulation and Scientific Studies Trends

Mª Pilar Garralaga, Laura Lomba, Estefanía Zuriaga, Sonia Santander and Beatriz Giner

Applied Sciences, 2022, 12, 11710
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Integrating spheroid‐on‐a‐chip with tubeless rocker platform: A high‐throughput biological screening platform

Sina Kheiri, Zhengkun Chen, Ilya Yakavets, Faeze Rakhshani, Edmond W. K. Young and Eugenia Kumacheva

Biotechnology Journal, 2023, 18
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Towards in vitro models for reducing or replacing the use of animals in drug testing

David M. Stresser, Anna K. Kopec, Philip Hewitt, Rhiannon N. Hardwick, Terry R. Van Vleet, Prathap Kumar S. Mahalingaiah, Denice O’Connell, Gary J. Jenkins, Rhiannon David, Jessica Graham, Donna Lee, Jason Ekert, Aaron Fullerton, Remi Villenave, Piyush Bajaj, James R. Gosset, Sherry L. Ralston, Manti Guha, Alejandro Amador-Arjona, Kainat Khan, Saket Agarwal, Catrin Hasselgren, Xiaoting Wang, Khary Adams, Gaurav Kaushik, Arkadiusz Raczynski and Kimberly A. Homan

Nat. Biomed. Eng, 2023, 8, 930
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Global expansion of microphysiological systems (MPS) and Japan's initiatives: Innovation in pharmaceutical development and path to regulatory acceptance

Daiju Yamazaki and Seiichi Ishida

Drug Metabolism and Pharmacokinetics, 2025, 60, 101047
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A multi-strain human skin microbiome model provides a testbed for disease modeling

Angela L. Maloney, Tyler Crawford, Jordan Hurlbut, Monica Martinez, Thomas J. Mulhern, Elizabeth L. Wiellette, Else M. Vedula and Vidhya Vijayakumar

Front. Microbiomes, 2025, 4
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A call to action: Advancing new approach methodologies (NAMs) in regulatory toxicology through a unified framework for validation and acceptance

G. Ouedraogo, N. Alépée, B. Tan and C.S. Roper

Regulatory Toxicology and Pharmacology, 2025, 162, 105904
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Recent advances in 3D printed microneedles and their skin delivery application in the treatment of various diseases

Rabinarayan Parhi

Journal of Drug Delivery Science and Technology, 2023, 84, 104395
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The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary

Thomas K. Baker, Terry R. Van Vleet, Prathap Kumar Mahalingaiah, Taraka Sai Pavan Grandhi, Raymond Evers, Jason Ekert, James R. Gosset, Silvi A. Chacko and Anna K. Kopec

Drug Metabolism and Disposition, 2024, 52, 198
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Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment—A Review

Yvonne Kohl, Elise Rundén-Pran, Espen Mariussen, Michelle Hesler, Naouale El Yamani, Eleonora Marta Longhin and Maria Dusinska

Nanomaterials, 2020, 10, 1911
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Evaluation of in vitro human skin models for studying effects of external stressors and stimuli and developing treatment modalities

Emily Sutterby, Peter Thurgood, Sara Baratchi, Khashayar Khoshmanesh and Elena Pirogova

VIEW, 2022, 3
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Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities

Tengku Ibrahim Maulana, Nienke R. Wevers, Theodora Kristoforus, Morgan Chandler, Henriette L. Lanz, Jos Joore, Paul Vulto, Remi Villenave, Stefan Kustermann, Peter Loskill and Kristin M. Bircsak

Annual Review of Pharmacology and Toxicology, 2025, 65, 47
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Anatomy of a bioengineered human pigmented skin equivalent to provide fundamental insights into skin tone melanin dynamics

Paola De Los Santos Gomez, Ranjit Rai, Pamela Ritchie, Lucy Smith, Amy Simpson, Kirsty Goncalves and Stefan Przyborski

Journal of Anatomy, 2025
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The Use of MPS in Three Rs and Regulatory Applications: Perspectives From Developers on Stakeholder Responsibilities

Megan R. LaFollette, Szczepan W. Baran, J. Lowry Curley, Anne M. Dickinson, Trivia Frazier, Nina Hobi, Ming-I Huang, Victoria Hutter, Benoît G.C. Maisonneuve, Graham A. Marsh, Rhamiya Mahendran, Iris Müller, Xiaohua Qian, Dharaminder Singh, William R. Thelin, Jelena Vukasinovic, Pelin L. Candarlioglu and Clive S. Roper

Altern Lab Anim, 2025, 53, 26
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Applications of Genome-wide Screening of CRISPR/Cas9 Knockout Library in Identifying Novel Molecular Targets for Xenobiotics

Simin Lang, Xueyang Lin, Shengran Wang, Weiqiang Sun, Yufeng Yang, Chen Yang, Zhenghao Bao, Wenya Feng, Yongan Wang and Yuan Luo

Environ. Health, 2025
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Assessment of Skin Toxicity in an in Vitro Reconstituted Human Epidermis Model Using Deep Learning

Fangyao Hu, Sara F. Santagostino, Dimitry M. Danilenko, Min Tseng, Jochen Brumm, Philip Zehnder and Kai Connie Wu

The American Journal of Pathology, 2022, 192, 687
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Development of Skin-On-A-Chip Platforms for Different Utilizations: Factors to Be Considered

J. Ponmozhi, S. Dhinakaran, Zsófia Varga-Medveczky, Katalin Fónagy, Luca Anna Bors, Kristóf Iván and Franciska Erdő

Micromachines, 2021, 12, 294
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Microphysiological systems: What it takes for community adoption

Passley Hargrove-Grimes, Lucie A Low and Danilo A Tagle

Exp Biol Med (Maywood), 2021, 246, 1435
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Genetic variants affecting chemical mediated skin immunotoxicity

Isisdoris Rodrigues de Souza, Patrícia Savio de Araujo-Souza and Daniela Morais Leme

Journal of Toxicology and Environmental Health, Part B, 2022, 25, 43
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The Growing Importance of Three-Dimensional Models and Microphysiological Systems in the Assessment of Mycotoxin Toxicity

Veronica Zingales, Maria Rosaria Esposito, Noemi Torriero, Mercedes Taroncher, Elisa Cimetta and María-José Ruiz

Toxins, 2023, 15, 422
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Durability and physical characterization of anti-fogging solution for 3D-printed clear masks and face shields

Succhay Gadhar, Shaina Chechang, Philip Sales and Praveen Arany

PeerJ Materials Science, 2023, 5, e30
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Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip

Huub J. Weener, Heleen H. T. Middelkamp and Andries D. Van der Meer

Front. Toxicol., 2024, 6
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Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project

Seiichi Ishida

Front. Toxicol., 2021, 3
DOI: 10.3389/ftox.2021.657765

Research progress in the development of 3D skin models and their application to in vitro skin irritation testing

Hongxia Lu, Xulei Zuo, Jiayu Yuan, Zhuoying Xie, Lihong Yin, Yuepu Pu, Zaozao Chen and Juan Zhang

J of Applied Toxicology, 2024, 44, 1302
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Preclinical safety of tetrahydrocurcumin loaded lipidic nanoparticles incorporated into tacrolimus ointment: In vitro and in vivo evaluation

Komal Saini, Caamin Arora, Megha Saini, Saurabh Sharma, Deepak Chitkara and Vandita Kakkar

Food and Chemical Toxicology, 2022, 167, 113260
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Applicability of organ-on-chip systems in toxicology and pharmacology

Marlon R. Schneider, Michael Oelgeschlaeger, Tanja Burgdorf, Peter van Meer, Peter Theunissen, Anne S. Kienhuis, Aldert H. Piersma and Rob J. Vandebriel

Critical Reviews in Toxicology, 2021, 51, 540
DOI: 10.1080/10408444.2021.1953439

Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development

Lindsay Tomlinson, Diane Ramsden, Sofia Batista Leite, Sonja Beken, Jessica A. Bonzo, Paul Brown, Pelin L. Candarlioglu, Tom S. Chan, Eugene Chen, Colin K. Choi, Rhiannon David, Nathalie Delrue, Patrick J. Devine, Kevin Ford, Martha Iveth Garcia, James R. Gosset, Philip Hewitt, Kimberly Homan, Onyi Irrechukwu, Anna K. Kopec, Jennifer L. Liras, Sandhya Mandlekar, Arek Raczynski, Nakissa Sadrieh, Melanie Z. Sakatis, Jeffrey Siegel, Kyung Sung, Ilona Sunyovszki, Terry R. Van Vleet, Jason E. Ekert and Rhiannon N. Hardwick

Advanced Biology, 2024, 8
DOI: 10.1002/adbi.202300131

The beneficial activity of curcumin and resveratrol loaded in nanoemulgel for healing of burn-induced wounds

Abdullah Alyoussef, Riham I. El-Gogary, Rania F. Ahmed, Omar AH. Ahmed Farid, Rofanda M. Bakeer and Maha Nasr

Journal of Drug Delivery Science and Technology, 2021, 62, 102360
DOI: 10.1016/j.jddst.2021.102360