Issue 35, 2013
From the journal:

Chemical Communications

Enantioselective tandem reaction of chromone-derived Morita–Baylis–Hillman carbonates with benzylamines catalyzed by a trifunctional organocatalyst: the synthesis of chiral 3-aminomethylene-flavanones†

Neng-jun Zhong,ab   Li Liu,*a   Dong Wanga  and  Yong-Jun Chen*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: lliu@iccas.ac.cn
Fax: +86 10 6255 4449
Tel: +86 10 6255 4614

b Graduate School of Chinese Academy of Sciences, Beijing 100049, China

Abstract

An enantioselective tandem reaction of chromones-derived MBH carbonates (1) with benzylamines (2) catalyzed by a trifunctional organocatalyst, cinchonidine–amide–thiourea, has been developed in moderate to good yields (50–87%) and enantioselectivities (up to 89% ee).

Graphical abstract: Enantioselective tandem reaction of chromone-derived Morita–Baylis–Hillman carbonates with benzylamines catalyzed by a trifunctional organocatalyst: the synthesis of chiral 3-aminomethylene-flavanones

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Article information

DOI
https://doi.org/10.1039/C3CC41011K
Article type
Communication
Submitted
06 Feb 2013
Accepted
11 Mar 2013
First published
13 Mar 2013

Chem. Commun., 2013,49, 3697-3699

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Enantioselective tandem reaction of chromone-derived Morita–Baylis–Hillman carbonates with benzylamines catalyzed by a trifunctional organocatalyst: the synthesis of chiral 3-aminomethylene-flavanones

N. Zhong, L. Liu, D. Wang and Y. Chen, Chem. Commun., 2013, 49, 3697 DOI: 10.1039/C3CC41011K

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