Electrosynthesis deamination functionalization via C-N bond cleavage and radical formation

Abstract

The C-N bond cleavage of amines have gained attention in the scientific community due to their numerous synthetic applications. In the traditional methods, the requirements for toxic oxidants and costly catalysts affect their costeffectiveness and sustainability. However, recent advances in synthetic organic electrochemistry allow for the in situ activation of the C-N bonds, affording different functionalizations under mild reaction conditions and with a shorter reaction time. In light of the ever-increasing importance of electrosynthesis spanning most disciplines of the chemical sciences, we review the recent development of electrochemically promoted radical deamination functionalization over the past decade years (from 2015 to 2025). Special emphasis is put on various electrochemical transformation paths and propoesd mechanisms.