Jiashun Cheng, Pinhong Chen and Guosheng Liu
Org. Chem. Front., 2014,1, 289-293
DOI:
10.1039/C4QO00002A,
Research Article
A facile Pd-catalyzed cascade cyclization of N-alkenylamine and pyruvic acids has been developed to construct spiro-N,O-acetals. This transformation was initiated by an intramolecular oxidative amination of alkenes, followed by hydrolysis to give a ketone intermediate, which further reacts with pyruvic acid to deliver the final spiro-N,O-acetals.
