Issue 51, 2012
From the journal:

Chemical Communications

Solvent dependence of helix stability in aromatic oligoamide foldamers†‡

Ting Qi,ab   Victor Maurizot,ab   Hiroki Noguchi,c   Thiraporn Charoenraks,c   Brice Kauffmann,def   Makoto Takafuji,cg   Hirotaka Iharacg  and  Ivan Huc*ab  

* Corresponding authors

a Univ. Bordeaux, CBMN, UMR 5248, Institut Européen de Chimie et Biologie, 2 rue Escarpit, F-33600 Pessac, France
E-mail: i.huc@iecb.u-bordeaux.fr
Fax: +33 54000 2215
Tel: +33 54000 2219

b CNRS, CBMN, UMR 5248, Institut Européen de Chimie et Biologie, 2 rue Escarpit, F-33600 Pessac, France

c Department of Applied Chemistry and Biochemistry, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555, Japan

d Univ. Bordeaux, IECB, UMS 3033, F-33600 Pessac, France

e CNRS, IECB, UMS 3033, F-33600 Pessac, France

f INSERM, IECB, US 0001, F-33600 Pessac, France

g Kumamoto Institute for Photo-Electro Organics (PHOENICS), Japan

Abstract

A new helical aromatic oligoamide foldamer, bearing triethyleneglycol side chains for solubility in a broad range of media, was prepared. The stability of the helical conformation was assessed in various solvents and shown to vary greatly and unexpectedly. Stability was remarkably enhanced in methanol–water mixtures.

Graphical abstract: Solvent dependence of helix stability in aromatic oligoamide foldamers

  • This article is part of the themed collection: Chirality
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Article information

DOI
https://doi.org/10.1039/C2CC31533E
Article type
Communication
Submitted
29 Feb 2012
Accepted
10 Apr 2012
First published
11 Apr 2012

Chem. Commun., 2012,48, 6337-6339

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Solvent dependence of helix stability in aromatic oligoamide foldamers

T. Qi, V. Maurizot, H. Noguchi, T. Charoenraks, B. Kauffmann, M. Takafuji, H. Ihara and I. Huc, Chem. Commun., 2012, 48, 6337 DOI: 10.1039/C2CC31533E

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