Intramolecular migration of [Pt(dien)]²⁺ (dien = 1,5-diamino-3-azapentane) from sulfur to imidazole-N¹ in histidylmethionine (his-metH)

Abstract

HPLC and NMR investigations of the kinetics of competitive binding by neighbouring side chains in his-metH demonstrate that at pH > 6 initial S coordination is followed by slow isomerization to an imidazole-N¹ bound complex through a dinuclear intermediate [{Pt(dien)}₂(his-metH-1κN¹ :2κS)]⁴⁺

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