A novel route to various substituted isothiazolo[4,5-b]pyridines was established. The compounds completely lacked GAK affinity, which was explained by in silico analysis.
This manuscript reports the synthesis and X-ray characterization of a series of 3-substituted 4,5-dichloroisothiazoles and the analysis of recurrent motifs.
A direct one-pot synthesis for novel heterocycles, isothiazole-3-thiones and isoselenazole-3-selenones via the annulation of ferrocenyl/phenyl-β-chloro acrylaldehyde, amines and chalcogen powder (S and Se) has been established.
A new two-step, one-pot synthesis of benzo[f][1,2]thiazepine 1,1-dioxides was developed based on a visible-light mediated aza Paternò–Büchi reaction and a Lewis acid catalyzed ring-expansion of azetidine.
Two different series of europium(III), terbium(III) and gadolinium(III) complexes with 4,5-dichloroisothiazole-3-carboxylic acid (HL) were obtained.