This review explores linear cascade reactions by combining chemo-, photo- and biocatalysts for organic synthesis and strategies to overcome incompatibility issues.
Theoretical calculations, such as pKa-determinations, enabled the design of methods for the selective functionalization of the underexplored 6-chloroimidazo[1,2-a]pyrazine using readily available TMP-bases and organometallic reagents.
A novel synthetic strategy to construct pyrrolo[1,2-a]pyrazines has been developed utilizing a 1,5-dicarbonyl precursor through C–C bond formation between methylene group and ethyl cyanoformate under basic conditions.
Herein, we present the iodine catalyzed an efficient synthesis of imidazo[1,2-a]pyrazine and pyridine derivatives and studied their anticancer activities against in vitro cancer cell lines namely, Hep-2, HepG2, MCF-7, and A375.
By utilizing the dual reactivity function of N-aminopyridinium ylides, we developed a direct [3 + 2]-cycloaddition of N-aminopyridinium ylides and ynals to build the pyrazolo[1,5-a]pyridine core while introducing a cyano group.