N-Sulfenyl phthalimides as efficient radicalophile reagents is herein reported to enable the Markovnikov hydrothiolation of unactivated alkenes by cobalt catalysis with exclusive regio-selectivity and wide functional group tolerance.
A new light-promoted cobalt-catalyzed protocol has been developed for the radical Markovnikov hydrothiolation of alkenes, using Hantzsch ester as a mild reducing agent and N-arylsulfenyl phthalimides as thiyl radical precursors.
A Re(I)-catalysed dual hydroalkylation method enables Markovnikov-selective O–C(sp2)–H functionalisation of phenols and anti-Markovnikov hydroalkylation of thiophenols. Biologically important phenols also undergo efficient ortho-functionalisation.
Metal-catalyzed highly Markovnikov-type selective hydrofunctionalization of terminal alkynes providing a straightforward and atom-economical route to access 1,1-disubstituted alkenes has been summarized.
Based on experimental results and DFT studies, a detailed reaction mechanism is presented for the CuNPs/TiO2-catalysed hydrothiolation of activated alkynes with thiols bearing a catechol group.