Multicomponent reactions for the synthesis of novel chromeno[1,6]naphthyridine derivatives via condensation reactions of salicylaldehyde derivatives, malononitrile dimer, and active methylene compounds in PEG-400.
A silver-catalyzed one-pot, regio- and chemoselective synthesis of benzo[b][1,7]- and benzo[c][2,7]-naphthyridines via Michael addition–cyclization is reported, supported by NMR evidence and enabling access to novel perlolidine analogs.
A series of novel 2,7-naphthyridine derivatives were designed with potential applications in optical switching. The electronic properties and nonlinear optical properties of the designed compounds were extensively studied using DFT.
Twenty-eight compounds, viz., 1,8-naphthyridine-3-carbonitrile (ANC and ANA) derivatives, were designed and synthesized through a molecular hybridization approach. The designed compounds were evaluated for anti-TB activity against Mtb H37Rv strain.
Given the high toxicity of inorganic inhibitors, organic substances, primarily heterocycles, have been proven to be one of the most efficient, cost-effective, and practical alternatives.