Ethyl 3-oxo-3-phenylpropanoate reacts with phenyl(pyridin-2-yl)methanamine to afford a selective product via the site-selective C–C bond cleavage of ethyl 3-oxo-3-phenylpropanoate by adjusting reaction parameters.
We developed a CBr4-mediated, sustainable, solvent-free method to synthesize 2-arylimidazo[1,2-a]pyridines from 2-aminopyridines and acetophenones, enabling one-pot, oxidant-free C3 amino-functionalization and C3 bromo-functionalization using K2S2O8.
A series of 3-(2,2-dialkyl-2H-chromen-4-yl)-2-phenylimidazo[1,2-a]pyridine derivatives were synthesis. Molecular docking studies and antibacterial evaluation validates as potent druggable antibacterial agents in future.
A series of novel phenothiazine-containing imidazo[1,2-a]pyridine derivatives were designed and synthesized under metal-free conditions in excellent yield.
A click-based oxime protocol to extend small molecule microarray-derived TDP1 inhibitory platform to project into the DNA and TOP1 peptide substrate-binding channels.