This review highlights advances in one-pot multicomponent synthesis of naphthyridine derivatives, focusing on efficient, atom-economical methods, diverse scaffolds and mechanistic insights fostering innovation in organic synthesis.
A series of novel 2,7-naphthyridine derivatives were designed with potential applications in optical switching. The electronic properties and nonlinear optical properties of the designed compounds were extensively studied using DFT.
A silver-catalyzed one-pot, regio- and chemoselective synthesis of benzo[b][1,7]- and benzo[c][2,7]-naphthyridines via Michael addition–cyclization is reported, supported by NMR evidence and enabling access to novel perlolidine analogs.
In this investigation, we synthesized pyridonaphthyridines, as a new class of fused heterocyclic compounds, through an efficient multicomponent reaction.
An 131I-labeled α-amylase inhibitor shows exceptional stomach retention (59.6% ID per g) and sustained intestinal uptake, highlighting its promise as a GI-targeted antidiabetic agent and potential GI imaging probe.