Direct alteration of unactivated C–H bonds of organic building blocks.
Herein, we have demonstrated a comprehensive perspective and potential application of traceless directing group strategy.
Pd-catalyzed ortho-C(sp3)–H arylation of aromatic aldehydes using 2-amino-N-methyl-acetamide as a simple, efficient and commercially available L,L-type transient directing group (TDG) is reported.
In the last decade numerous techniques have been developed in Pd-catalysed distal C–H activation ranging from template-assisted to the use of inherent functional groups as the directing auxiliary including ligand-enabled transformations.
The site-selective cross-dehydrogenative coupling (CDC) of aromatic aldehydes and arenes enabled by heterogeneous glucose-based melanoidin-supported Pd single-atoms/clusters cocatalysts was reported.