KHMDS mediated ring-opening/reconstruction of anthranils with arylacetonitriles: synthesis of multisubstituted 2-aminoquinoline N-oxides

Abstract

A convenient and atom-economical protocol for the construction of multisubstituted 2-aminoquinoline N-oxides using readily available starting materials anthranil and arylacetonitrile has been reported.

Rational identification of a catalytically promiscuous nitrilase by predicting a unique catalytic triad motif feature through an in silico strategy

Abstract

A key motif of a catalytically promiscuous nitrilase (CP-NLase) was identified by mimicking active site features from cyanide hydratases (CHTs) in combination with structural analysis.

Reductive ortho-cyanomethylation of aryl iodanes with MeCN via one-pot iodonium-Claisen rearrangement

Abstract

The one-pot iodonium-Claisen rearrangement of aryl iodanes with acetonitrile facilitates the simultaneous incorporation of cyanomethyl and iodide groups into arenes.

Correction: Blue-light induced iron-catalyzed chemoselective α-alkylation and α-olefination of arylacetonitriles with alcohols

Base metal complexes featuring a new pyrazole-derived PCP pincer ligand

Abstract

The syntheses of various base metal complexes featuring a new pyrazole-derived pincer ligand containing a 1-methylpyrazole backbone tethered to two di(isopropyl)phosphine moieties via phenylene spacers are described.