Mixed-linker approach employing a flexible monomer for constructing highly crystalline multiple-component covalent organic frameworks.
Oxepanes and thiepanes are central motifs and tenants of many biologically important molecules. This comprehensive review covers synthetic methods for their preparation and use in the total synthesis of polyoxygenated oxepane natural products.
Molecular descriptors and machine learning are useful tools for extracting structure–property relationships from large, complex polymer data, and accelerating the design of novel polymers with tailored functionalities.
This review details enantioselective methods for the Mukaiyama–Michael reaction, a powerful approach for the formation of C–C bonds and hindered stereocenters, and highlights applications in the total synthesis of natural products.
A decade of ingenuity in total synthesis is captured through diverse strategies – Diels–Alder reactions, radical cascades, [2 + 2 + 2] cycloadditions, and Ir-catalysed allylations – for intricate rubriflordilactones A–C.