Known for its widespread outbreaks, including the 2013–2016 epidemic that resulted in around 11 300 deaths, Ebola virus (EBOV) and related filoviruses remain a current threat as consecutive filoviral outbreaks have occurred between 2021 through 2025.
Next-generation POCT devices for infectious diseases will improve disease management.
The structure of the VP40 dimer interface was used to design a series of constrained peptides that mimic the interaction. Constrained peptides were probed for VP40 binding affinity and ability to shift VP40 dimer–monomer equilibrium.
DC-SIGN and L-SIGN are C-type lectin receptors that act as viral coreceptors for SARS-CoV-2. Their distinct tissue localization justifies the search for a selective ligand for L-SIGN, despite their high homology suggesting the task hard to achieve.
This highlight explores the key role of thiophene-based compounds in organic electronics, sensors, medicinal chemistry, solid-state reactions, crystal engineering, and supramolecular helices, using X-ray, DFT, and microscopy techniques.