N-Sulfenyl phthalimides as efficient radicalophile reagents is herein reported to enable the Markovnikov hydrothiolation of unactivated alkenes by cobalt catalysis with exclusive regio-selectivity and wide functional group tolerance.
Based on experimental results and DFT studies, a detailed reaction mechanism is presented for the CuNPs/TiO2-catalysed hydrothiolation of activated alkynes with thiols bearing a catechol group.
A copper-catalyzed syn-hydrothiolation of internal alkynes with thiosulfonates and silanes has been disclosed, which offers regio- and stereoselective access to (E)-vinyl sulfides.
A new light-promoted cobalt-catalyzed protocol has been developed for the radical Markovnikov hydrothiolation of alkenes, using Hantzsch ester as a mild reducing agent and N-arylsulfenyl phthalimides as thiyl radical precursors.
Functionalization of the [(C^C)Au(dppe)]+ core through an efficient, chemoselective and functional group tolerant hydrothiolation reaction was achieved.