Benzothiazoles are an important class of heterocycles for the synthesis of pharmaceuticals. This review describes many direct and green methods for the synthesis of 2-substituted benzothiazoles under transition metal catalysis or metal-free systems.
The need for diverse essential chemicals and resources has markedly risen alongside the advancement of civilization.
This review highlights the recent synthetic developments of benzothiazole based anti-tubercular compounds. Structure activity relationship of benzothiazole derivatives with molecular docking studies of selected compounds have been discussed against the target DprE1.
A series of 2-arylbenzothiazoles and their derivatives were prepared in high yields by visible light-induced intramolecular cyclization under mild conditions using TAPT-TP-COF as a photocatalyst.
The optimal photosynthesis of 2-arylbenzothiazoles over hexaazatrinaphthylene-based porous aromatic frameworks (HATN-PAFs) is achieved in high yields (up to 99%) with a broad substrate scope (20 examples) and good recyclability (10 cycles).