The sulfonamide scaffold is widely applied in drug discovery. In recent years, there has been growing investigation on cyclic sulfonamides (sultams) as they offer much potential in combating various diseases.
γ-Sultams bearing a trifluorinated ethyl- or an ene-gem-difluorinated tether were obtained from CF3-substituted N-allenamides; experimental and DFT calculations suggested that this transformation involves a 5-endo-dig cyclization on the ene-ynamide generated in situ.
Visible-light-induced three-component reactions, which were performed under extremely mild conditions without the need for any additional additives and catalysts and showed a broad substrate scope, gave the corresponding quinazoline-based hybrids in good to excellent yields.
A strategy has been developed to separate SO2 gas from other toxic gases. The cheletropic reaction between silica-supported α,β-unsaturated iminium salt LI@MOS with SO2 gas showed reversible adsorption–desorption as high as 20 mmolg−1.
The regiodivergent synthesis of exomethylene-bearing azatricyclic products was achieved via aza-[4 + 2] annulations of cyclic imines with a single C4 synthon, the α-vinyl MBH adduct.