2,3-Dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones as broad-spectrum cytotoxic agents and their impact on tubulin polymerisation

Nicholas S. O'Brien, Jayne Gilbert, Adam McCluskey and Jennette A. Sakoff

RSC Med. Chem., 2024,15, 1686-1708

Abstract

Simple synthesis, binds and inhibits tubulin, and potent broad-spectrum cytotoxicity.

An efficient approach for the green synthesis of biologically active 2,3-dihydroquinazolin-4(1H)-ones using a magnetic EDTA coated copper based nanocomposite

Sahil Kohli, Garima Rathee, Sunita Hooda and Ramesh Chandra

RSC Adv., 2023,13, 1923-1932

Abstract

The fabricated catalyst Fe₃O₄@EDTA/CuI facilitates the synthesis of 2,3-dihydroquinazolin-4(1H)-ones under sustainable conditions with ideal values of green metrics in a short reaction time.

Aluminium-based ionic liquid grafted on biochar as a heterogeneous catalyst for the selective synthesis of tetrazole and 2,3-dihydroquinazolin 4(1H)-one derivatives

Masoomeh Norouzi, Parisa Moradi and Maryam Khanmoradi

RSC Adv., 2023,13, 35569-35582

Abstract

2,3-Dihydroquinazolin-4(1H)-one and tetrazole are a class of nitrogen-containing heterocyclic compounds that play an important role in drug design and are an important part of many biological and industrial compounds.

Green chemistry approach to the synthesis of 2-aryl/heteroaryl substituted 2,3-dihydroquinazolin-4(1H)-ones using lemon juice under concentrated solar radiations as a renewable source

Rehana A. Khan, Vishnu A. Adole, Thansing B. Pawar and Bapu S. Jagdale

RSC Adv., 2024,14, 32350-32357

Abstract

This study explores a novel and eco-friendly synthesis of 22 derivatives of 2-aryl/heteroaryl substituted 2,3-dihydroquinazolin-4(1H)-ones using concentrated solar radiation (CSR) and lemon juice as a natural catalyst.

Introduction of [C₄(DABCO)₂]·(CuCl₄) as an efficient catalyst for the green synthesis of pyrano[2,3-d]pyrimidinones and dihydropyrano[3,2-c]chromenes and dual pathway synthesis of 2,3-dihydroquinazolinone derivatives

Fatemeh Mirzaei Eslamlou, Maryam Mousapour and Farhad Shirini

New J. Chem., 2025,49, 17285-17299

Abstract

In this study, an environmentally friendly and highly efficient one-pot procedure was introduced for the synthesis of pyrano[2,3-d]pyrimidinones via a three-component reaction featuring malononitrile, aldehydes, and barbituric acid.

2,3-Dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones as broad-spectrum cytotoxic agents and their impact on tubulin polymerisation

Abstract

An efficient approach for the green synthesis of biologically active 2,3-dihydroquinazolin-4(1H)-ones using a magnetic EDTA coated copper based nanocomposite

Abstract

Aluminium-based ionic liquid grafted on biochar as a heterogeneous catalyst for the selective synthesis of tetrazole and 2,3-dihydroquinazolin 4(1H)-one derivatives

Abstract

Green chemistry approach to the synthesis of 2-aryl/heteroaryl substituted 2,3-dihydroquinazolin-4(1H)-ones using lemon juice under concentrated solar radiations as a renewable source

Abstract

Introduction of [C4(DABCO)2]·(CuCl4) as an efficient catalyst for the green synthesis of pyrano[2,3-d]pyrimidinones and dihydropyrano[3,2-c]chromenes and dual pathway synthesis of 2,3-dihydroquinazolinone derivatives

Abstract

Introduction of [C₄(DABCO)₂]·(CuCl₄) as an efficient catalyst for the green synthesis of pyrano[2,3-d]pyrimidinones and dihydropyrano[3,2-c]chromenes and dual pathway synthesis of 2,3-dihydroquinazolinone derivatives