Discovery of natural products that modulate signaling in patient-derived cells

Joseph A. Balsamo, Hannah L. Thirman, Kathryn E. Penton, Jordan T. Froese, Benjamin J. Reisman, Sierra M. Lima, Madeline J. Grider-Hayes, Chad R. Potts, Jonathan M. Irish, P. Brent Ferrell and Brian O. Bachmann

RSC Chem. Biol., 2026
DOI: 10.1039/D5CB00203F

Biosynthesis of reveromycin derivatives by altering the regioselectivity of cytochrome P450revI

Ya Fen Yong, Song Liu, Katsuyuki Sakai, Keisuke Fujiyama, Hiroshi Takagi, Yushi Futamura, Takeshi Shimizu, Hiroyuki Osada, Eugene Boon Beng Ong and Shunji Takahashi

Chem. Sci., 2025, 16, 13106
DOI: 10.1039/D5SC01355K

Isolation and total synthesis of a cytotoxic polyketide lead from Aspergillus sp. YUD22001 associated with Panax notoginseng rhizosphere

Yan Zhang, Hong-Tao Li, Yan Geng, Hai-Xia Dong, Tian-Peng Xie, Dan-Dan Xia, Xing-Mi Lin, Ling Ma, Min Yin, Hao Zhou and Zhong-Tao Ding

Org. Biomol. Chem., 2025, 23, 9430
DOI: 10.1039/D5OB01364J

Pyroptosis induced by natural products and their derivatives for cancer therapy

Yingfei Wen, You Li, Bin-bin Li, Peng Liu, Miaojuan Qiu, Zihang Li, Jiaqi Xu, Bo Bi, Shiqiang Zhang, Xinyi Deng, Kaiyuan Liu, Shangbo Zhou, Qiang Wang and Jing Zhao

Biomater. Sci., 2024, 12, 5656
DOI: 10.1039/D4BM01023J

Progress on targeted discovery of microbial natural products based on the predictions of both structure and activity

Yuwei Zhang, Jianfa Zong, Yufeng Liu, Keyu Zhou, Haibo Shi, Wen-Bing Yin, Ling Liu and Yihua Chen

Nat. Prod. Rep., 2025, 42, 1651
DOI: 10.1039/D5NP00008D

Thienopyrimidine scaffolds as promising antimicrobial agents: synthesis, biological evaluation, DFT analysis and molecular docking

Mostafa Sayed, Menna A. Naguib, Ahmed A. K. Mohammed, Reda Hassanien, Mahmoud S. Tolba and Mostafa Ahmed

RSC Adv., 2026, 16, 5606
DOI: 10.1039/D5RA09678B

Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering

Biyan Chen, Emre F. Bülbül, SeoungGun Bang, Hannah A. Minas and Kenan A. J. Bozhüyük

Nat. Prod. Rep., 2026, 43, 352
DOI: 10.1039/D5NP00041F

Huangshui polysaccharides from baijiu fermentation by-products: Emerging structures, functional activities, structure-function relationships and green valorization perspectives

Wei Cheng, Qiang Chang, Yongqing Li, Xuefeng Chen and Yuxi Guo

Journal of Functional Foods, 2025, 133, 107004
DOI: 10.1016/j.jff.2025.107004

Integrated Computer-Aided Drug Design: Advances in GPCR Natural Ligand Discovery

Abdullahi Ibrahim Uba

Cell Biochem Biophys, 2025, 84, 179
DOI: 10.1007/s12013-025-01902-3

Phytochemical analysis and bioactivities of different organs of Bunium ferulaceum Sm

Achraf Khaldi, Abdelkader Elhadj Berrezig, Amina Mazeri, Mehdi Kheira and Rahima Hadjer Gouabi

Chem. J. Mold., 2025, 20, 65
DOI: 10.19261/cjm.2025.1369

SAR studies of chabrolonaphthoquinone B via rational design and synthesis of analogues - Cytotoxicity evaluation uncovers anticancer activity via mRNA splicing modulation

Varnavas Y. Charalambous, Ioanna Sigala, Konstantinos A. Ouzounthanasis, Stergios R. Rizos, Christiana Mantzourani, Maroula G. Kokotou, Konstantina C. Fylaktakidou, Thomas Giannakouros, Eleni Nikolakaki and Alexandros E. Koumbis

European Journal of Medicinal Chemistry, 2025, 300, 118175
DOI: 10.1016/j.ejmech.2025.118175

Rational design, synthesis of some quinolinone-Schiff bases/ pyridazino[4,5-c]quinolinones with potent anti-lung cancer and antituberculosis performance

Eslam A. Ghaith, Nedaa N. Elnaggar and Wafaa S. Hamama

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-22255-0

Cancer chemoprevention: signaling pathways and strategic approaches

Junling Ren, Guangli Yan, Le Yang, Ling Kong, Yu Guan, Hui Sun, Chang Liu, Lei Liu, Ying Han and Xijun Wang

Sig Transduct Target Ther, 2025, 10
DOI: 10.1038/s41392-025-02167-1

Leveraging molecular graphs for natural product classification

Alessia Lucia Prete, Barbara Toniella Corradini, Filippo Costanti, Franco Scarselli and Monica Bianchini

Comput Struct Biotechnol J, 2025, 27, 3837
DOI: 10.1016/j.csbj.2025.08.031

Breaking the antimicrobial resistance dilemma: marine natural products, a treasure trove for the development of new anti-Staphylococcus aureus drugs

Peng-Jie Li, Liu-Xia Lv, Xi-Zhen Cao, Jian-Yu Liu, Ji-Xiu Gao, Hao-Ran Li, Gulab Said, Dan Chen, Bo Yao, Xin Liu, Mei-Yan Wei, Xiao-Ping Yang, Tong-Yi Xu, Yu-Cheng Gu and Chang-Lun Shao

Mar Life Sci Technol, 2026
DOI: 10.1007/s42995-026-00355-8

Isolation, biosynthesis, and biological activity of pradimicins from actinomycetes

Yuhua Guo, Fulai Yu, Gang Li, Tiaokun Fu and Chao Yuan

Bioorganic Chemistry, 2025, 164, 108884
DOI: 10.1016/j.bioorg.2025.108884

Discovery of new 1,2,3,4-tetrahydro-β-carboline derivatives decorated with 3-N-substituted propionyl moiety flexibly bridged-chain as reactive oxygen species inducer for efficient antibacterial treatment

Yike Yang, Shanshan Su, Zhaoju Sun, Zhouqing Long, Xichun Fu, Jiao Meng, Xiang Zhou, Liwei Liu and Song Yang

Bioorganic Chemistry, 2025, 160, 108473
DOI: 10.1016/j.bioorg.2025.108473

Genome-Guided Metabolomic Profiling of Peptaibol-Producing Trichoderma

Arseniy A. Sinichich, Danil V. Krivonos, Anna A. Baranova, Mikhail Y. Zhitlov, Olga A. Belozerova, Vladislav A. Lushpa, Andrey V. Vvedensky, Marina V. Serebryakova, Anastasia I. Kalganova, Arsen M. Kudzhaev, Yuri A. Prokopenko, Sofia S. Sinelnikova, Ekaterina A. Trusova, Sergey I. Kovalchuk, Elena N. Ilina, Stanislav S. Terekhov and Vera A. Alferova

IJMS, 2025, 26, 5599
DOI: 10.3390/ijms26125599

Artificial intelligence in natural products research

Xiao Yuan, Xiaobo Yang, Qiyuan Pan, Cheng Luo, Xin Luan and Hao Zhang

Chinese Journal of Natural Medicines, 2025, 23, 1342
DOI: 10.1016/S1875-5364(25)60902-2

A tri-scale in silico framework integrating pharmacovigilance and mechanistic modeling suggests tepotinib-associated acute kidney injury risk

Rubin Zheng, Jiaxi Chen, Jinfen Han, Jiayi Lyu, Qin Wang, Miao Deng, Jing Lu and Zhixun Bai

Renal Failure, 2026, 48
DOI: 10.1080/0886022X.2025.2610895

Comprehensive Characterization and Hepatotoxicity Prediction of Pyrrolizidine Alkaloids from Emilia sonchifolia (L.) DC. via Building Block Molecular Networking and Network Toxicology

Shujun Shan, Peipei Du, Su Zheng, Congcong Liu and Guirong Chen

Processes, 2026, 14, 786
DOI: 10.3390/pr14050786

Alterbrassacids A and B: Two Novel Fusicoccane Diterpenoids with Protective Activity Against H2O2-Induced Cardiomyocyte Injury from the Fungus Alternaria brassicicola

Rui Jiang, Shenglan Yang, Jiayi Guo, Xiaoqi Jin, Jiangchun Wei, Weiguang Sun, Jieru Guo, Yonghui Zhang and Zhengxi Hu

Synlett, 2025, 36, 2029
DOI: 10.1055/s-0043-1775448

Recent progress in chemistry and bioactivity of novel enzyme inhibitors from natural products: A comprehensive review

Chengqian Pan and Hideaki Kakeya

European Journal of Medicinal Chemistry, 2025, 289, 117481
DOI: 10.1016/j.ejmech.2025.117481

Total Synthesis and Functional Analysis of Loihichelin C: Structural Basis for Mn(III) Stabilization and Mn(II) Oxidation

Mizuki Sawada, Hiromu Kakizawa, Aoi Takeuchi, Hiroaki Itoh and Masayuki Inoue

JACS Au, 2026, 6, 1868
DOI: 10.1021/jacsau.5c01730

Traditional Chinese medicine in the treatment of breast Cancer

Peng Song, Tongtong Liu, Yinfang Zhang, Tingting Shao, Rongkun Li, Chaoxia An, Lu-Qi Cao, Zhe-Sheng Chen, Wenjing Guo and Dongzhu Duan

Mol Cancer, 2025, 24
DOI: 10.1186/s12943-025-02416-5

Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors

Kun Li, Yue Zeng, Yi-da Xiong, Hao-chen Wu, Sui Fang, Zhi-yan Qu, Yan Zhu, Bo Du, Zhao-bing Gao and Wen-bin Hu

Acta Pharmacol Sin, 2025, 46, 3116
DOI: 10.1038/s41401-025-01580-0

Genomic Investigation of a Rhizosphere Isolate, Streptomyces sp. JL1001, Associated with Polygonatum cyrtonema Hua

Lin Jiang, Zixian Zeng, Zhi Wang, Min Tang, Sai Jiang, Qingxian Ma, Zhong Wang, Dian Peng, Shunxiang Li and Hong Pu

Curr Microbiol, 2024, 81
DOI: 10.1007/s00284-024-03887-3

New drug discovery and development from natural products: Advances and strategies

Yixin Wang, Fan Wang, Wenxiu Liu, Yifei Geng, Yahong Shi, Yu Tian, Bin Zhang, Yun Luo and Xiaobo Sun

Pharmacology & Therapeutics, 2024, 264, 108752
DOI: 10.1016/j.pharmthera.2024.108752

New Phthalide Derivatives With Cardioprotective Effects From the Marine Fungus Diaporthe phaseolorum HZ‐2

Ran‐Qi Feng, Yan‐Qiu Hu, Xin‐Yu Wang, Zhen Gao, Han‐Bin Lin and Xu‐Wen Li

Chemistry & Biodiversity, 2026, 23
DOI: 10.1002/cbdv.202503780

Patient-derived organoids: Advancing research on bioactive natural compounds in lung cancer

Xiao Chen and Xian Lin

Journal of Holistic Integrative Pharmacy, 2025, 6, 204
DOI: 10.1016/j.jhip.2025.06.008

A comprehensive review of the phytochemical and pharmacological potential of Alnus glutinosa (L.) Gaertn., (Black Alder)

Atif Ali Khan Khalil, Salsabila and Hanhong Bae

Med Chem Res, 2025, 34, 2052
DOI: 10.1007/s00044-025-03473-7

Feruloyl substitution is associated with distinct neurogenic and metabolic signatures in cinnamoylquinic acid derivatives: An integrated transcriptomic–metabolomic analysis

Farhana Ferdousi, Yu Jia Chen, Kazunori Sasaki and Hiroko Isoda

Biomedicine & Pharmacotherapy, 2026, 198, 119255
DOI: 10.1016/j.biopha.2026.119255

Ailanthone: A multi-targeting Quassinoid from Ailanthus altissima for broad-spectrum cancer therapy - a comprehensive review of mechanisms, pharmacokinetics, and clinical prospects

Yongjun Huang, Haowei Chen, Yuhan Jiang, Ziwei Meng, Chun She, Zhiying Miao and Youlong Fan

Journal of Ethnopharmacology, 2026, 355, 120716
DOI: 10.1016/j.jep.2025.120716

Glycosylation Matters: Network Pharmacology-Based and Molecular Docking Analysis of Resveratrol Glycosylated Derivatives on Parkinson’s Disease

Lucia E. Schimith, Elvis Martis, Stéphane Teletchea, Ana Luiza Muccillo-Baisch, Corinne André-Miral and Mariana A. Hort

ACS Omega, 2026, 11, 7597
DOI: 10.1021/acsomega.5c08887

Targeting the Unfolded Protein Response with Natural Products: Therapeutic Potential in ER Stress-Related Diseases

Simona Martinotti and Elia Ranzato

IJMS, 2025, 26, 8814
DOI: 10.3390/ijms26188814

Benchmarking methods for measuring biosynthetic gene cluster similarity and determination of gene cluster families

Abiodun S Oyedele, Allison S Walker and Macha Nikolski

Bioinformatics, 2025, 41
DOI: 10.1093/bioinformatics/btaf636

Therapeutic potential of celastrol in bacterial infections: Current research advancements and future perspectives

Ziwei Meng, Qing Liu, Haowei Chen, Chun She and Yongjun Huang

Pharmacological Research, 2025, 216, 107774
DOI: 10.1016/j.phrs.2025.107774

Natural compounds regulating fatty acid oxidation in the treatment of diabetic kidney disease

Jianing Sun, Chengqian Yin, Zhe Li, Xiangyu Gao, Songlin Li, Hua Gao, Yan An, Peng Liu and Na Liu

Front. Nutr., 2025, 12
DOI: 10.3389/fnut.2025.1669557

How can nanoemulgels improve the therapeutic benefit of naturally derived compounds?

Denise Tiemi Uchida, Gabrielli Furlan, Maria Vitoria Gouveia Botan, Mariana Carla de Oliveira and Marcos Luciano Bruschi

Therapeutic Delivery, 2025, 16, 1207
DOI: 10.1080/20415990.2025.2580911

Effect of lathyrane-type diterpenoids in neural stem cell physiology: Microbial transformations, molecular docking and dynamics studies

Felipe Escobar-Montaño, Ricardo Gómez-Oliva, Abdellah Ezzanad, Sonia Vázquez de Górgolas, David Zorrilla, Antonio J. Macías-Sánchez, José M. Botubol-Ares, Pedro Nunez-Abades, Carmen Castro, Rosa Durán-Patrón and Rosario Hernández-Galán

Bioorganic Chemistry, 2024, 153, 107769
DOI: 10.1016/j.bioorg.2024.107769

Catharanthus roseus Phytochemicals as Multi-Target Modulators of Disability-Linked Neurodegeneration: Bio-Computational Insights

Qazi Mohammad Sajid Jamal, Ali H. Alharbi, Varish Ahmad and Khurshid Ahmad

Pharmaceuticals, 2025, 18, 1734
DOI: 10.3390/ph18111734

Phytoflavonoids as alternative therapeutic effect for melanoma: Integrative Network pharmacology, molecular dynamics and drug-likeness profiling for lead discovery

Manoj Kumar Prajapati, Abhilasha Mittal and Pritipadma Panda

Computational Biology and Chemistry, 2025, 117, 108390
DOI: 10.1016/j.compbiolchem.2025.108390

Recent Developments in Shono-Type Oxidation: Strategies for Modular α-C(sp3)–H Functionalization

Siyuan Su, Yahui Guo and Joseph Derosa

ACS Electrochem., 2026, 2, 14
DOI: 10.1021/acselectrochem.5c00443