Advances in adhesion of microneedles for bioengineering

Zhen Gu, Kaiyu Song, Heng An, Dadi Sun, Yinglei Ma, Hanyu Wang, Yanxia Chen, Qi Gu and Yongqiang Wen

J. Mater. Chem. B, 2025, 13, 2592
DOI: 10.1039/D4TB02517B

Intradermal delivery of an angiotensin II receptor blocker using a personalized microneedle patch for treatment of hypertrophic scars

Yihui Huang, Jingwen Li, Yan Wang, Danyang Chen, Jianglong Huang, Wubin Dai, Pan Peng, Liang Guo and Yifeng Lei

Biomater. Sci., 2023, 11, 583
DOI: 10.1039/D2BM01631A

Fabrication and application of microneedle systems for adipose tissue reduction

Tuling Cai, Minghao Guo, Si Qin, Dawei Sun, Xiao Yu, Chengyong Wang and Zhishan Yuan

Biomater. Sci., 2026, 14, 56
DOI: 10.1039/D5BM00716J

Penetration enhancers strengthen tough hydrogel bioadhesion and modulate locoregional drug delivery

Wenna Shi, Hui Xue, Tianwei Du, Jun-Li Liu, Victor Ling, Yuzhuo Wang, Zhenwei Ma and Zu-hua Gao

Biomater. Sci., 2024, 12, 5620
DOI: 10.1039/D4BM00807C

Recent Progress on the Application of Microneedles for In Situ Sampling in Surface-Enhanced Raman Scattering Detection

Weiqing Yang, Ying Chen, Xingliang Cheng, Shuojiang Liu, Huiqi Zhu and Yuling Hu

Biosensors, 2025, 15, 350
DOI: 10.3390/bios15060350

Micro Needle Drug Delivery Technology: A New Way to Break through Traditional Drug Delivery Methods

利群施

PI, 2024, 13, 125
DOI: 10.12677/pi.2024.132016

Lidocaine-Loaded Iontophoresis-Driven Fiber-Based Microneedle Patch for Controllable and Long-Lasting Transdermal Local Analgesia

Ting Wang, Xiaoyu Shi, Yue Wang, Hengda Sun, Yu Sun, Gang Wang and Hong Jiang

Adv. Fiber Mater., 2025, 7, 281
DOI: 10.1007/s42765-024-00486-6

Microneedle technology in analgesic therapy

Jie Jiao, Ze Qiang Zhao, Yu Ting He, Bin Bin Yu, Kejun Chen, Youchen Xia, Ruixing Yu, Bo Zhi Chen and Xin Dong Guo

Nano Research, 2025, 18, 94907083
DOI: 10.26599/NR.2025.94907083

Microneedle biomedical devices

Mengjia Zheng, Tao Sheng, Jicheng Yu, Zhen Gu and Chenjie Xu

Nat Rev Bioeng, 2023, 2, 324
DOI: 10.1038/s44222-023-00141-6

Microneedle: classification, preparation and applications

Jichuan Kong, Miao Shi, Feng Zhou, Liting Shi, Lingkai Cui, Chunhong Wu and Zongguang Tai

International Journal of Pharmaceutics, 2026, 696, 126826
DOI: 10.1016/j.ijpharm.2026.126826

Active integrated fabrication method and evaluation of polymer with microneedles LED light source integration

Xiaoning Zhang, Qingxin Han, Xiaoqing Hu, Lei Zhang, Xiaoya Kang, Ming Li, Qiang Gao, Fengyi Liu, Jingyao Sun, Jingxian Zhu and Jian Zhuang

Microsyst Technol, 2025, 31, 199
DOI: 10.1007/s00542-024-05731-x

HAMA/GelMA-based hydrogel microneedle patch via DLP 3D bioprinting for high-efficiency ISF extraction

Lujie Zhang, Qinghua Song, Peijing Yang and Zhanqiang Liu

International Journal of Pharmaceutics, 2025, 680, 125800
DOI: 10.1016/j.ijpharm.2025.125800

Industrializable approach for preparing hydrogel microneedles and their application in melanoma treatment

Mengzhen Xing, Guozhong Yang, Han Liu, Zequan Zhou, Suohui Zhang and Yunhua Gao

International Journal of Pharmaceutics, 2024, 653, 123883
DOI: 10.1016/j.ijpharm.2024.123883

Ulvan Microneedles Loaded with Photosensitizer 5-aminolevulinic Acid Inhibits Human Cervical Cancer HeLa Cells In vitro

Wenxin Hu, Jie Wei, Sen Zheng, Guan Jiang, Bei Zhang and Zhen Liang

ACAMC, 2025, 25, 1113
DOI: 10.2174/0118715206358815250224043946

Microneedle system for tissue engineering and regenerative medicines: a smart and efficient therapeutic approach

Muhammad Umar Aslam Khan, Muhammad Azhar Aslam, Mohd Faizal Bin Abdullah, Hilal Gul, Goran M Stojanović, Abdalla Abdal-Hay and Anwarul Hasan

Biofabrication, 2024, 16, 042005
DOI: 10.1088/1758-5090/ad6d90

Ultrasound-activatable and skin-associated minimally invasive microdevices for smart drug delivery and diagnosis

Qi Zeng, Guanyue Li and Wei Chen

Advanced Drug Delivery Reviews, 2023, 203, 115133
DOI: 10.1016/j.addr.2023.115133

Novel strategy for Poxviridae prevention: Thermostable combined subunit vaccine patch with intense immune response

Yuan Wen, Shuyue Deng, Tianmin Wang, Mengtian Gao, Wenlong Nan, Fang Tang, Qinghong Xue, Yanmin Ju, Jianjun Dai, Yurong Wei and Feng Xue

Antiviral Research, 2024, 228, 105943
DOI: 10.1016/j.antiviral.2024.105943

Conditioned medium of engineering macrophages combined with soluble microneedles promote diabetic wound healing

HongYu Wang, BaoHua Wei, Hasi WuLan, Bin Qu, HuiLong Li, Jing Ren, Yan Han, LingLi Guo and Zhengwei Huang

PLoS ONE, 2025, 20, e0316398
DOI: 10.1371/journal.pone.0316398

A smart closed-loop microneedle system for self-regulated blood glucose management

Xue Wang, Lin He, Zihan Li and Zongqian Hu

Biosensors and Bioelectronics, 2026, 308, 118561
DOI: 10.1016/j.bios.2026.118561

Microneedles integrated with crystallinity control for poorly water-soluble drugs: Enhanced bioavailability and innovative controlled release system

Mi Ran Woo, Jung Suk Kim, Seunghyun Cheon, Sang Hun Ji, Seonghyeon Park, Sanghyun Woo, Jong Oh Kim, Sung Giu Jin and Han-Gon Choi

Materials & Design, 2024, 247, 113371
DOI: 10.1016/j.matdes.2024.113371

Microneedles for in situ tissue regeneration

Linyu Long, Dan Ji, Cheng Hu, Li Yang, Shibo Tang and Yunbing Wang

Materials Today Bio, 2023, 19, 100579
DOI: 10.1016/j.mtbio.2023.100579

Revolutionizing diabetic wound healing: The power of microneedles

Chun Liang, Ren Wang, Tian He, Dongsheng Chen, Guangliang Zhang, Xiangye Yin, Hongyu Wang, Jiale Xie, Yujing Li and Youbai Chen

Chinese Journal of Plastic and Reconstructive Surgery, 2023, 5, 185
DOI: 10.1016/j.cjprs.2023.12.004

Polymeric Microneedles for Biomedical Applications: Innovations in Transdermal Drug Delivery and Biosensing Technologies

Wendel A. Alves, Jose E. U. Rojas, Ana C. H. Castro-Kochi, Leandro T. Kochi, Ana C. D. L. V. Reis, Freddy A. N. Esteves, Priscila S. Ferreira, Fabíola L. de Castro, Rafael C. Otoni, Jonas B. Barreto, Vivian L. de Oliveira and Ana A. Zaneli

Biomedical Materials & Devices, 2026, 4, 1325
DOI: 10.1007/s44174-025-00330-4

Advances of Microneedles for Cancer Diagnosis and Therapy

Chunli Yang, Li Zhang, Siyi Wang, Angxi Zhou, Run Tian, Maya Xiang, Ya Ren, Yang Yu, Rong Li and Maling Gou

MedComm – Biomaterials and Applications, 2025, 4
DOI: 10.1002/mba2.70018

Wearable bioelectronics for cancer theranostics

Zhichen Hua, Changhao Dai, Yufan Yang and Yu Song

Microsyst Nanoeng, 2025, 11
DOI: 10.1038/s41378-025-01048-5

Fiber-Reinforced Silk Microneedle Patches for Improved Tissue Adhesion in Treating Diabetic Wound Infections

Yixin Wang, Pengpeng Guan, Ruiyi Tan, Zhenghui Shi, Qing Li, Bitao Lu, Enling Hu, Weiwei Ding, Wenyi Wang, Bowen Cheng, Guangqian Lan and Fei Lu

Adv. Fiber Mater., 2024, 6, 1596
DOI: 10.1007/s42765-024-00439-z

Advancements in Materials for 3D-Printed Microneedle Arrays: Enhancing Performance and Biocompatibility

Mahmood Razzaghi, Joel Alexander Ninan and Mohsen Akbari

Micromachines, 2024, 15, 1433
DOI: 10.3390/mi15121433

Cutting-edge microneedle innovations: Transforming the landscape of cardiovascular and metabolic disease management

Xiaoning Zhang, Ming Li, Qiang Gao, Xiaoya Kang, Jingyao Sun, Yao Huang, Hong Xu, Jing Xu, Songren Shu, Jian Zhuang and Yuan Huang

iScience, 2024, 27, 110615
DOI: 10.1016/j.isci.2024.110615

Dendrobium polysaccharide-based microneedles loaded with Celosia cristata flavonoids and adapalene nanoparticles for efficacious treatment of acne vulgaris

Fanglin Li, Shuqin Pang, Shiqi Hao, Yuanyuan Liu, Wenwen Lei, Wenying Zhong and Keming Xu

International Journal of Biological Macromolecules, 2025, 310, 143480
DOI: 10.1016/j.ijbiomac.2025.143480

Harnessing Polymeric Dissolvable Microneedles: Precision Delivery of Therapeutics for Oral Ulcers

Maria Nison, Megha Kotian, Vasudev R. Pai, Sony Priyanka Bandi, Popat Mohite and Deepanjan Datta

ACS Omega, 2025, 10, 56932
DOI: 10.1021/acsomega.5c05654

An aptamer-integrated conductive microneedle biosensor for real-time transdermal cortisol monitoring

Li Yue Jing, Yangkai Fan, Bo Zhi Chen, Dehui Li, Yu Ting He, Guo Liang Zhang, Ling Liang, Jie Du, Yuan Wang and Xin Dong Guo

Chemical Engineering Journal, 2024, 502, 157488
DOI: 10.1016/j.cej.2024.157488

Natural polysaccharide-based microneedles: A promising frontier in cancer immunotherapy

Chunling Zhang, Min Tang, Ye Wu, Jiayi Lin, Jiyuan Zhang, Weidong Zhang, Bei Wang and Xin Luan

Glycoscience & Therapy, 2025, 1, 100010
DOI: 10.1016/j.glycos.2025.100010

Strategies to develop polymeric microneedles for controlled drug release

Bo Zhi Chen, Yu Ting He, Ze Qiang Zhao, Yun Hao Feng, Ling Liang, Juan Peng, Chen Yu Yang, Hiroshi Uyama, Mohammad-Ali Shahbazi and Xin Dong Guo

Advanced Drug Delivery Reviews, 2023, 203, 115109
DOI: 10.1016/j.addr.2023.115109

Advances in microneedle-based therapy for bone disorders

Zengping Lin, Kanghua Zheng, Jiping Zhong and Xufeng Zheng

Biomedicine & Pharmacotherapy, 2023, 165, 115013
DOI: 10.1016/j.biopha.2023.115013

Leveraging Microneedles for Raised Scar Management

Zhengyun Jin, Young-Seong Kim and Joong Yeon Lim

Polymers, 2025, 17, 108
DOI: 10.3390/polym17010108

Application of Convergent Science and Technology toward Ocular Disease Treatment

Ayça Bal-Öztürk, Ece Özcan-Bülbül, Hazal Ezgi Gültekin, Berivan Cecen, Ebru Demir, Atefeh Zarepour, Sibel Cetinel and Ali Zarrabi

Pharmaceuticals, 2023, 16, 445
DOI: 10.3390/ph16030445

Collagen‐Based Dissolving Microneedles with Flexible Pedestals: A Transdermal Delivery System for Both Anti‐Aging and Skin Diseases

Hongqian Lv, Nan Gao, Qixin Zhou, Yan Wang, Guixia Ling and Peng Zhang

Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202203295

Double-layered microneedle patch loaded with bioinspired nano-vaccine for melanoma treatment and wound healing

Zesheng Chen, Zicheng Guo, Tao Hu, Bohan Huang, Qihang Zheng, Xun Du, Lei Huang and Weikang Hu

International Journal of Biological Macromolecules, 2024, 262, 129961
DOI: 10.1016/j.ijbiomac.2024.129961

Microneedles‐Integrated Photothermal‐Based Combinational Therapeutics for Cancer Treatment

Dinesh Kumar, Harpreet Singh, Akash Deep, Joerg Opitz, Natalia Beshchasna and Sanjeev Soni

Adv Materials Technologies, 2026
DOI: 10.1002/admt.71039

Dissolving alginate-based blend microneedles with enhanced mechanical performance for transdermal delivery of vitamin B12

Shatha Salameh, Hala Dawud and Aiman Abu Ammar

Journal of Drug Delivery Science and Technology, 2024, 102, 106391
DOI: 10.1016/j.jddst.2024.106391

Upconverting Nanoparticle‐Loaded Microneedles for Near‐Infrared Responsive Delivery of Gonadotropins to Increase Success of In Vitro Fertilization

Vivienne Tam, Rusvir Trana, Alfonso Nieto‐Arguello, Ore‐Oluwa Olasubulumi, Samuel Babity, Artiom Skripka, Fiorenzo Vetrone, Davide Brambilla and Marta Cerruti

Small, 2026, 22
DOI: 10.1002/smll.202513138

Microneedles Based on a Biodegradable Polymer—Hyaluronic Acid

Jagoda Chudzińska, Agata Wawrzyńczak and Agnieszka Feliczak-Guzik

Polymers, 2024, 16, 1396
DOI: 10.3390/polym16101396

High-density AuNP-decorated microneedle electrochemical aptasensor for minimally invasive CEA detection in interstitial fluid

Ziwei Lian, Tianlang Ou, Kuo Men, Qianhui Wei, Feng Wei, Hongbin Zhao, Zhimin Yang and Hailing Tu

Microchim Acta, 2025, 192
DOI: 10.1007/s00604-025-07622-y

Transdermal Drug Delivery System: Current Status and Clinical Application of Microneedles

Yanan Xue, Cheng Chen, Xiangyu Mi, Rong Tan, Ji Wang, Sufan Wu, Yue Wang, Rong Xiong, Mengxiao Chen, Wei-Qiang Tan and Haojian Lu

ACS Materials Lett., 2024, 6, 801
DOI: 10.1021/acsmaterialslett.3c01317

Microneedle sensors for dermal interstitial fluid analysis

Gwangmook Kim, Hyunah Ahn, Joshua Chaj Ulloa and Wei Gao

Med-X, 2024, 2
DOI: 10.1007/s44258-024-00028-0

Advances in chitosan-based materials for oral ulcer treatment

Xinying Zhang, Jiayun Lei, Tingting Qu and Xiangyan Zhang

Carbohydrate Polymers, 2025, 368, 124110
DOI: 10.1016/j.carbpol.2025.124110