Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles

Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay and Tugba Boyunegmez Tumer

RSC Med. Chem., 2025, 16, 732
DOI: 10.1039/D4MD00495G

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu and Yan Cheng

Advanced Science, 2026, 13
DOI: 10.1002/advs.202520863

Impact of silencing eEF2K expression on the malignant properties of chordoma

Esra Aydemir, Emre Can Tüysüz, Ömer Faruk Bayrak, Didem Tecimel, Ayşen Aslı Hızlı-Deniz and Fikrettin Şahin

Mol Biol Rep, 2023, 50, 3011
DOI: 10.1007/s11033-023-08257-z

The Potential Role of Boron in the Modulation of Gut Microbiota Composition: An In Vivo Pilot Study

Nermin Basak Sentürk, Burcu Kasapoglu, Eray Sahin, Orhan Ozcan, Mehmet Ozansoy, Muzaffer Beyza Ozansoy, Pinar Siyah, Ugur Sezerman and Fikrettin Sahin

Pharmaceuticals, 2024, 17, 1334
DOI: 10.3390/ph17101334

Repurposing drugs for EGFR-targeted cancer therapy: An in silico and in vitro study with pharmacophore-based insights

Pınar Siyah and Firat Baris Barlas

Journal of Molecular Graphics and Modelling, 2026, 144, 109288
DOI: 10.1016/j.jmgm.2026.109288

Recent Advancements in Refashioning of NSAIDs and their Derivatives as Anticancer Candidates

Asmaa E. Kassab and Ehab M. Gedawy

CPD, 2024, 30, 1217
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Advanced Computational Pipeline for FAK Inhibitor Discovery: Combining Multiple Docking Methods with MD and QSAR for Cancer Therapy

Pinar Siyah

Computation, 2024, 12, 222
DOI: 10.3390/computation12110222

Targeting eukaryotic elongation factor 2 kinase (eEF2K) with small-molecule inhibitors for cancer therapy

Huiping Wang, Wenke Jin, Zixiang Li, Chuanxin Guo, Lan Zhang and Leilei Fu

Drug Discovery Today, 2024, 29, 104155
DOI: 10.1016/j.drudis.2024.104155

Exploring the antineoplastic potential of novel NSAID derivatives in combatting mammary tumorigenesis: a comprehensive review

Rashmi Dewangan, Nidhi Agrawal, S. K. Lanjhiyana and Meenakshi Jaiswal

Med Chem Res, 2025, 34, 764
DOI: 10.1007/s00044-025-03377-6

Endoplasmic Reticulum Stress–Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells

Serdar Karakurt, Hatice Gül Batur, Kemal Bas and Pinar Siyah

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202403305

Targeting IL‐23 with Small Molecule Inhibitors: A New Horizon In Psoriasis Therapy

Raghad Sharbaji and Pinar Siyah

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202406013

Unravelling the oncogenic role of eukaryotic elongation factor 2 kinase: A revisited review from underlying mechanisms to targeted therapy

Lingjuan Zhu, Minru Liao, Zhichao Fan, Yu Tang, Junning Wen, Qingbo Liu and Bo Liu

International Journal of Biological Macromolecules, 2025, 330, 148014
DOI: 10.1016/j.ijbiomac.2025.148014

A concise review on recent development of indole derivatives for anticancer activities

B.T. Sridhar, Nagesh Gunavanthrao Yernale, Ramesh S. Gani, Nidhi Gupta, Sharanabasava V. Ganachari and Basavarajaiah Suliphuldevara Mathada

Journal of the Indian Chemical Society, 2024, 101, 101282
DOI: 10.1016/j.jics.2024.101282

Synthesis and In Silico Evaluation of Piperazine-Substituted 2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone Derivatives as Potential PARP-1 Inhibitors

Ulviyye Nemetova, Pınar Si̇yah, Tuğçe Boran, Çiğdem Bi̇lgi̇, Mustafa Özyürek and Sibel Şahi̇nler Ayla

ACS Omega, 2024
DOI: 10.1021/acsomega.4c04915

Combination eEF2K gene and drug delivery for treatment of breast cancer

Cansu Umran Tunc, Nitish Khurana and Hamidreza Ghandehari

Journal of Bioactive and Compatible Polymers, 2024, 39, 440
DOI: 10.1177/08839115241267809