Synthesis and SARs of benzimidazoles: insights into antimicrobial innovation (2018–2024)

Ahmed A. Ibrahim, Eman G. Said, Asmaa M. AboulMagd, Noha H. Amin and Hamdy M. Abdel-Rahman

RSC Adv., 2025, 15, 22097
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Benzimidazole(s): synthons, bioactive lead structures, total synthesis, and the profiling of major bioactive categories

Lotfi M. Aroua, Fahad M. Alminderej, Hind R. Almuhaylan, Abdulelah H. Alosaimi, Faten Medini, Hamdoon A. Mohammed, Suliman A. Almahmoud, Riaz A. Khan and Nejib H. Mekni

RSC Adv., 2025, 15, 7571
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Biological assessments of novel ultrasound-synthesized 2-arylbenzimidazole derivatives: antiproliferative and antibacterial effects

Ivana Sokol, Anja Rakas, Dajana Kučić Grgić, Leentje Persoons, Dirk Daelemans and Tatjana Gazivoda Kraljević

RSC Med. Chem., 2025, 16, 3197
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New metal complexes of 1H-benzimidazole-2-yl hydrazones: Cytostatic, proapoptotic and modulatory activity on kinase signaling pathways

Maria Argirova, Emiliya Cherneva, Rositsa Mihaylova, Georgi Momekov and Denitsa Yancheva

Archives of Biochemistry and Biophysics, 2025, 764, 110245
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Radical Scavenging Mechanisms of 1-Arylhydrazone Benzimidazole Hybrids with Neuroprotective Activity

Miglena K. Georgieva, Neda Anastassova, Denitsa Stefanova and Denitsa Yancheva

J. Phys. Chem. B, 2023, 127, 4364
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Synthesis and Antifungal Activity of Coumarin Derivatives Containing Hydrazone Moiety

Zibo Zhang, Dongxian Geng, Zhou Yang, Le Pan and Lu Jin

Chemistry & Biodiversity, 2024, 21
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Benzimidazoles Containing Piperazine Skeleton at C-2 Position as Promising Tubulin Modulators with Anthelmintic and Antineoplastic Activity

Kameliya Anichina, Anelia Mavrova, Dimitar Vuchev, Galya Popova-Daskalova, Giada Bassi, Arianna Rossi, Monica Montesi, Silvia Panseri, Filip Fratev and Emilia Naydenova

Pharmaceuticals, 2023, 16, 1518
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Benzimidazole-Triazole Hybrids as Antimicrobial and Antiviral Agents: A Systematic Review

Maria Marinescu

Antibiotics, 2023, 12, 1220
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Acetylresveratrol (AC-Res): An Evolving Frontier in Modulating Gene Expression

Uttam Prasad Panigrahy, Rahul Subhash Buchade, Sandhya Subhadra, Anoop Kumar Narayanan, Sachinkumar Dnyaneshwar Gunjal, Ezhilarasan Selvakumari, Narendra Kumar Pandey and Ankita Wal

CGT, 2025, 25, 210
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Radical scavenging mechanism of 1H-benzimidazole-2-yl hydrazones and kinetics with physiologically relevant radicals: A computational study

Miglena К. Georgieva, Maria Argirova and Denitsa Yancheva

Computational and Theoretical Chemistry, 2025, 1254, 115491
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Antiproliferative and Pro-Apoptotic Activity and Tubulin Dynamics Modulation of 1H-Benzimidazol-2-yl Hydrazones in Human Breast Cancer Cell Line MDA-MB-231

Denitsa Yancheva, Maria Argirova, Irina Georgieva, Vanya Milanova, Maya Guncheva, Miroslav Rangelov, Nadezhda Todorova and Rumiana Tzoneva

Molecules, 2024, 29, 2400
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Modulation Effect on Tubulin Polymerization, Cytotoxicity and Antioxidant Activity of 1H-Benzimidazole-2-Yl Hydrazones

Maria Argirova, Maya Guncheva, Georgi Momekov, Emiliya Cherneva, Rositsa Mihaylova, Miroslav Rangelov, Nadezhda Todorova, Petko Denev, Kameliya Anichina, Anelia Mavrova and Denitsa Yancheva

Molecules, 2022, 28, 291
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Design, synthesis, and mechanistic evaluation of novel benzimidazole-hydrazone compounds as dual inhibitors of EGFR and HER2: Promising candidates for anticancer therapy

Tebyan O. Mirgany, A.F.M. Motiur Rahman and Mohammed M. Alanazi

Journal of Molecular Structure, 2024, 1309, 138177
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Multistimuli Luminescence and Anthelmintic Activity of Zn(II) Complexes Based on 1H-Benzimidazole-2-yl Hydrazone Ligands

Alexey Gusev, Elena Braga, Alexandr Kaleukh, Michail Baevsky, Mikhail Kiskin and Wolfgang Linert

Inorganics, 2024, 12, 256
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Transition metal complexes of benzimidazole-based ligands: Synthesis, characterization, biological, and catecholase activities

Nouman, Manish Rana, Saiema Ahmedi, Rabiya Mehandi, Manjeet Dhama, Nikhat Manzoor and Rahisuddin

Inorganica Chimica Acta, 2025, 574, 122392
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Synthesis and In Vitro Biological Studies of Heterocyclic Benzimidazole Derivatives as Potential Therapeutics for Trichinellosis

Kameliya Anichina, Galya Popova-Daskalova, Dimitar Vuchev, Maya Guncheva, Denitsa Yancheva and Nikolai Georgiev

Applied Sciences, 2025, 15, 6758
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Novel Fluorescent Benzimidazole-Hydrazone-Loaded Micellar Carriers for Controlled Release: Impact on Cell Toxicity, Nuclear and Microtubule Alterations in Breast Cancer Cells

Rayna Bryaskova, Nikolai Georgiev, Nikoleta Philipova, Ventsislav Bakov, Kameliya Anichina, Maria Argirova, Sonia Apostolova, Irina Georgieva and Rumiana Tzoneva

Pharmaceutics, 2023, 15, 1753
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Scaffolds imparting anthelmintic activity: recent advancements and SAR studies

Pawan Kumar, Rohit Bhatia and Naresh Kumar Rangra

Mol Divers, 2025, 29, 783
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Green Synthesis of Silver Oxide Nanoparticles using Zingiber officinale Extract: Catalytic and Antibacterial Potentials of 2-Phenyl Benzimidazole Derivatives

Qurat Ul Ain Yasin, Rabia Sattar and Muhammad Amin

CENG, 2025, 124
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Two 5-Methoxyindole Carboxylic Acid-Derived Hydrazones of Neuropharmacological Interest: Synthesis, Crystal Structure, and Chemiluminescent Study of Radical Scavenging Properties

Neda Anastassova, Nadya Hristova-Avakumova, Rusi Rusew, Boris Shivachev and Denitsa Yancheva

Crystals, 2024, 14, 396
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Stability and Reactivity of Two Benzimidazole Hydrazide-Hydrazone Compounds: A Theoretical Study by DFT Method

Amon Assoma, Affoué Bede, Patrick-Armand Achi and Siomenan Coulibali

IJCTC, 2024, 12, 10
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Benzimidazole and its derivatives: Recent Advances (2020–2022)

Oluwakemi Ebenezer, Funsho Oyetunde-Joshua, Oluwadamilare D. Omotoso and Micheal Shapi

Results in Chemistry, 2023, 5, 100925
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A Review on Functionalization of Benzo‐5,6‐Fused Bicyclic Heteroaromatic Compounds

Marappan Pradeep Kumar, Aksa S Annie, Vikash Kumar Bind, Ramesh Adithya, P. Amaladass and Vasudevan Dhayalan

Chemistry An Asian Journal, 2024, 19
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Nanoformulations for Hydrazones; Synthesis, Characterization, Parasitology, and Histopathology Investigations

Eman M. Hassan, Ahmed R. Rabee, Saied M. Soliman, Mohamed Hagar, Esraa A. Moneer, Sherif Ramadan, Assem Barakat, Hamida Abdel-Hamid, Ahmed Zakaria and Hanaa A. Rasheed

ACS Omega, 2025, 10, 20226
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Fused Triazinobenzimidazoles Bearing Heterocyclic Moiety: Synthesis, Structure Investigations, and In Silico and In Vitro Biological Activity

Kameliya Anichina, Nikolai Georgiev, Nikolay Lumov, Dimitar Vuchev, Galya Popova-Daskalova, Georgi Momekov, Emiliya Cherneva, Rositsa Mihaylova, Anelia Mavrova, Stela Atanasova-Vladimirova, Iskra Piroeva and Denitsa Yancheva

Molecules, 2023, 28, 5034
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Novel Benzimidazole-Endowed Chalcones as α-Glucosidase and α-Amylase Inhibitors: An Insight into Structural and Computational Studies

Prashasthi V. Rai, Ramith Ramu, P. Akhileshwari, Sudharshan Prabhu, Nupura Manish Prabhune, P. V. Deepthi, P. T. Anjana, D. Ganavi, A. M. Vijesh, Khang Wen Goh, Mohammad Z. Ahmed and Vasantha Kumar

Molecules, 2024, 29, 5599
DOI: 10.3390/molecules29235599

Aerobic oxidation of 2-hydrazinyl-1-methyl-1H-benzo[d]imidazole in situ: A quantum chemical insight into the reaction background

Andrei V. Erkin and Viktor I. Krutikov

Chemical Data Collections, 2024, 53, 101161
DOI: 10.1016/j.cdc.2024.101161

Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin

Silviya Abarova, Katerina Stoitchkova, Svetlin Tzonev, Maria Argirova, Denitsa Yancheva, Neda Anastassova and Boris Tenchov

PHAR, 2024, 71, 1
DOI: 10.3897/pharmacia.71.e112385

Synthesis of 2-Substituted Benzimidazole Derivatives as a Platform for the Development of UV Filters and Radical Scavengers in Sunscreens

Kameliya K. Anichina and Nikolai I. Georgiev

Organics, 2023, 4, 524
DOI: 10.3390/org4040036