Urolithin B protects mice from diet-induced obesity, insulin resistance, and intestinal inflammation by regulating gut microbiota composition

Peng Chen, Rong Wang, Jiexin Lei, Lihua Feng and Benhong Zhou

Food Funct., 2024, 15, 7518
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Epigallocatechin-3-gallate alleviates galactose-induced aging impairment via gut–brain communication

Yi-Ping Luo, Xiao-Fang Tang, Yi-Chi Zhang, Su-Mei Chen, Qiong Wu and Wen-Juan Li

Food Funct., 2022, 13, 11200
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Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice

Wenwen Sun, Jiahao Zhu, Guanyu Qin, Yujie Huang, Siying Cheng, Zhengzhi Chen, Yeyang Zhang, Yifan Shu, Xiaoxiong Zeng and Renpeng Guo

International Journal of Biological Macromolecules, 2023, 245, 125517
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How to increase dietary polyphenol bioavailability: Understanding the roles of modulating factors, lifestyle and gut microbiota

Courage Sedem Dzah

Food and Humanity, 2025, 4, 100602
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Microbiome-based therapeutics towards healthier aging and longevity

Saurabh Kadyan, Gwoncheol Park, Tejinder P. Singh, Cole Patoine, Saiful Singar, Teresa Heise, Christin Domeier, Chester Ray, Manoj Kumar, Pradip V. Behare, Paramita Chakrabarty, Philip Efron, Julia Sheffler and Ravinder Nagpal

Genome Med, 2025, 17
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Polyphenol blend enhances zootechnical performance, improves meat quality, and reduces the severity of wooden breast in broiler chickens

Vivian Aparecida Rios de Castilho Heiss, Maria Fernanda de Castro Burbarelli, Bruna Barreto Przybulinski, Letícia Cuer Garcia, João Ricardo Rodrigues Ferreira Vieira, Rodrigo Garófallo Garcia, Fabiana Ribeiro Caldara, Elizabeth Santin, Claudia Andrea Lima Cardoso and Claudia Marie Komiyama

Front. Vet. Sci., 2025, 12
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Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF‐κB pathway

Yajun Li, Qi Zhuang, Lihong Tao, Kai Zheng, Shuangshuang Chen, Yunshang Yang, Chengcheng Feng, Zhifang Wang, Haiwei Shi, Jiandong Shi, Yiling Fang, Long Xiao, Dechun Geng and Zhirong Wang

Cell Proliferation, 2022, 55
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Recent Advances and Perspectives on the Health Benefits of Urolithin B, A Bioactive Natural Product Derived From Ellagitannins

Peng Chen, Zhiei Guo, Fuchao Chen, Yue Wu and Benhong Zhou

Front. Pharmacol., 2022, 13
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An experimental and theoretical study on mechanistic insights into urolithin-based ratiometric fluorescent probe for instant quantitative detection of fluoride ions

Yuanyue Wang, ChuChu Yang, Xiaoqing Feng and Yanying Zhao

Talanta, 2024, 276, 126220
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Natural polyphenols in the treatment of IBD: pathological intervention activities and delivery system constructions

Yi Zhang, Yi Chen, Yuyu Zhang, Qi Zhang, Lijuan Wang, Qingmei Liu, Liping Chen, Qin Dong, Yihao Wen, Ziyou He, Yawen Hu, Yuxin He, Zhejie Chen and Ling Li

Food Research International, 2026, 232, 118760
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Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases

Eman K. E. Anwer, Muhammad Ajagbe, Moustafa Sherif, Abobaker S. Musaibah, Shuaib Mahmoud, Ali ElBanbi and Anwar Abdelnaser

Biomedicines, 2025, 13, 100
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Disruption of intestinal epithelial permeability in the Co-culture system of Caco-2/HT29-MTX cells exposed individually or simultaneously to acrylamide and ochratoxin A

Jiawen Lu, Dan Su, Ying Yang, Mengni Shu, Yuting Wang, Xingtao Zhou, Qiang Yu, Chang Li, Jianhua Xie and Yi Chen

Food and Chemical Toxicology, 2024, 186, 114582
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Cow Placenta Peptides Ameliorate D-Galactose-Induced Intestinal Barrier Damage by Regulating TLR/NF-κB Pathway

Yuquan Zhao, Zhi Zeng, Weijian Zheng, Zeru Zhang, Hanwen Zhang, Yuxin Luo, Kunshan Zhao, Yuyan Ding, Wei Lu, Fuxing Hao, Yixin Huang and Liuhong Shen

Veterinary Sciences, 2025, 12, 229
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The Therapeutic Relevance of Urolithins, Intestinal Metabolites of Ellagitannin-Rich Food: A Systematic Review of In Vivo Studies

Wai-Kit Tow, Pui-Ying Chee, Usha Sundralingam and Uma Devi Palanisamy

Nutrients, 2022, 14, 3494
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Urolithin B as a renoprotective agent against 5-fluorouracil-induced nephrotoxicity: Role of Nrf2/Keap1/HO-1, SIRT1/FOXO3, and NF-кB/TNF-α signaling pathways

Mohammed W. Al-Rabia, Hani Z. Asfour, Rasha A. Mansouri, Wesam H. Abdulaal, Hani Choudhry, Dina S. El-Agamy, Nabil A. Alhakamy, Rakan Nasser Alrabea, Rami M. Mosaoa, Gamal A. Mohamed, Sabrin R.M. Ibrahim and Mahmoud Elshal

Food and Chemical Toxicology, 2025, 195, 115129
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2′-Fucosyllactose Ameliorates Oxidative Stress Damage in d-Galactose-Induced Aging Mice by Regulating Gut Microbiota and AMPK/SIRT1/FOXO1 Pathway

Jin Wang, Jia-Qiang Hu, Yu-Jie Song, Jia Yin, Yuan-Yi-Fei Wang, Bo Peng, Bo-Wei Zhang, Jing-Min Liu, Lu Dong and Shuo Wang

Foods, 2022, 11, 151
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Synthesis of urolithin derivatives and their anti-inflammatory activity

Xintong Li, Zhengzheng Zhang, Guangsen Xu, Zhiying Li, Chunhua Lu and Yuemao Shen

Biochemical and Biophysical Research Communications, 2024, 704, 149711
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The Gut Microbiota Metabolite Urolithin B Mitigates Cholestatic Liver Injury in Mice via Modulating the Crosstalk Between PPARα, Nrf2, and NF-κB Signaling Pathways

Hani M. Alrawili, Mahmoud Elshal, Marwa S. Serrya and Dina S. El-Agamy

JoX, 2025, 15, 128
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Neuroprotective effects of Urolithin A and B in an intracerebroventricular streptozotocin-induced Alzheimer’s-like model in rats

Mona Taghizade Salari, Kianoush Gholami, Leila Khani, Hananeh Ahmadnia, Milad Iranshahy, Mehrdad Iranshahi, Mohammad Tohidy Majd, Morteza Behnam-Rassouli, Omid Yazarlu and Maede Hasanpour

BMC Pharmacol Toxicol, 2026
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Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases

Nan Chen, Carmen K. Chan, Farhan Ullah Khan, Priya Makhijani, Taylor R. Valentino, Shawn Winer, Cynthia T. Luk and Daniel A. Winer

Ageing Research Reviews, 2026, 116, 103036
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Investigating the anticancer properties of urolithin B in triple negative breast cancer: In vivo and in vitro insights

Saeide Mansoori, Seyed Isaac Hashemy, Moein Eskandari, Azar Khorrami, Masoud Homayouni and Atefeh Ghahremanloo

Toxicology and Applied Pharmacology, 2025, 495, 117224
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Mechanistic Role of Coumarins Useful in Mitigating Inflammatory Bowel Disease

Bhagyabhumi Shah, Aditi Sharma, Vaidehi Prajapati, Nishtha Shah, Madhav Maheshwari and Nilay Solanki

Rev. Bras. Farmacogn., 2025, 35, 547
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Exogenous Nucleotides Ameliorate Ageing-Related Intestinal Inflammation in Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice

Mei You, Rui Liu, Chan Wei, Xiujuan Wang, Xiaochen Yu, Zhen Li, Ruixue Mao, Jiani Hu, Na Zhu, Xinran Liu, Rui Fan, Yong Li and Meihong Xu

Nutrients, 2023, 15, 2533
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Dietary supplementation of ark clams protects gut health and modifies gut microbiota in d‐galactose‐induced aging rats

Tao Tong, Jingya Guo, Ying Wu, Divya Sharma, Madhuri Sangar, Neeracha Sangpreecha, Doyoung Song, Tatsuya Unno, Kyung‐Sik Ham and Seong‐Gook Kang

J Sci Food Agric, 2024, 104, 675
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Essential roles of ellagic acid-to-urolithin converting bacteria in human health and health food industry: An updated review

Ziyan Hua, Qing Wu, Yang Yang, Shu Liu, Tchuere G. Jennifer, Danyue Zhao and Yaowei Fang

Trends in Food Science & Technology, 2024, 151, 104622
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Inhibitory Effects of Urolithins, Bioactive Gut Metabolites from Natural Polyphenols, against Glioblastoma Progression

Ching-Kai Shen, Bor-Ren Huang, Vichuda Charoensaensuk, Liang-Yo Yang, Cheng-Fang Tsai, Yu-Shu Liu, Sheng-Wei Lai, Dah-Yuu Lu, Wei-Lan Yeh and Chingju Lin

Nutrients, 2023, 15, 4854
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Metabolomic changes following PMSG-induced estrus synchronization in Qianbei Ma goats

Feng-Xin Qiao, Yong-Hong Ju, Xiao-Dong Wang, Peng-Cheng An, Quan Ji, Rui-Yang Li, Ting-Ji Zeng, Qing Liu, Dai-Yue Zhang, Zu-Han Feng, Mao-Sheng Cao and Xiang Chen

Animal Reproduction Science, 2026, 288, 108145
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The gut–joint axis in osteoarthritis: integrating microbiota-driven metaflammation and immunosenescence

Guoping Yang, Shengrong Bi, Xueli Zhang, Jinjin Zhong and Luwei Wu

International Immunopharmacology, 2026, 179, 116612
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The intestinal immune system and gut barrier function in obesity and ageing

Sarah J. Shemtov, Rohini Emani, Olga Bielska, Anthony J. Covarrubias, Eric Verdin, Julie K. Andersen and Daniel A. Winer

The FEBS Journal, 2023, 290, 4163
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Roles of blood metabolites in mediating the relationship between vitiligo and autoimmune diseases: Evidence from a Mendelian randomization study

Siyu Yang, Xinglin Hu, Puyu Zou, Zhuotong Zeng, Yibo Hu and Rong Xiao

International Immunopharmacology, 2024, 133, 112132
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Differences in Gut Microbiota between Healthy Individuals and Patients with Perianal Abscess before and after Surgery

Hezhai Yin, Bairu Luo, Qi Wang, Zhonghua Hong, Huilin Chen, Lidong Shen, Bin Shen, Bo Hu and Guangtao Xu

Mediators of Inflammation, 2023, 2023, 1
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Ellagic Acid and Gut Microbiota: Interactions, and Implications for Health

Pinze Leng, Ye Wang and Minhao Xie

Food Science & Nutrition, 2025, 13
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Urolithin B Attenuates Cerebral Ischemia–reperfusion Injury by Modulating Nrf2-regulated Anti-oxidation in Rats

Zhi-wei Li, Hua Tang, Xin-xin Chen, Xuan-xuan Li, Huan-huan Xu, Mao-hua Chen, Hua-jun Ba, Qun Lin, Jun-xia Dai, Jian-yong Cai, Chuan Lu, Xian-dong Chen, Guo-sheng Han and Jun Sun

Neuroscience, 2024, 538, 46
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Urolithin A alleviates schizophrenic-like behaviors and cognitive impairment in rats through modulation of neuroinflammation, neurogenesis, and synaptic plasticity

Zhengyuan Huang, Zhongyu Ren, Sanwang Wang, Ling Xiao, Yipeng Ling, Yinping Xie, Gaohua Wang and Benhong Zhou

Sci Rep, 2025, 15
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From dysbiosis to longevity: a narrative review into the gut microbiome’s impact on aging

Ching-Hung Tseng and Chun-Ying Wu

J Biomed Sci, 2025, 32
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Opportunities and challenges of foodborne polyphenols applied to anti-aging health foods

Hong Zhuang, Xiaoliang Zhang, Sijia Wu, Pang Yong and Haiyang Yan

Food Sci Biotechnol, 2024, 33, 3445
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