Immobilization of metal active centers in reticular framework materials for photocatalytic energy conversion

Shuo Wang, Wei Guo, Chao Li, Bo Weng, Shuai Liu, Ning Han, Jinlin Long and Honglei Zhang

J. Mater. Chem. A, 2024, 12, 12907
DOI: 10.1039/D4TA01683A

Recent progress in lactate oxidase-based drug delivery systems for enhanced cancer therapy

Lu Li, Tian Yue, Jie Feng, Yujun Zhang, Jun Hou and Yi Wang

Nanoscale, 2024, 16, 8739
DOI: 10.1039/D3NR05952A

Host molecules inside metal–organic frameworks: host@MOF and guest@host@MOF (Matrjoschka) materials

Qiao Wu, Jun Liang, Dan Wang, Ruihu Wang and Christoph Janiak

Chem. Soc. Rev., 2025, 54, 601
DOI: 10.1039/D4CS00371C

Facile and scale-up syntheses of high-performance enzyme@meso-HOF biocatalysts

Zhengyi Di, Yu Qi, Xin-Xin Yu, Hai-Ruo Li, Meng-Xuan Zuo, Tian-Tian Ren, Cheng-Peng Li and Yanli Zhao

Chem. Sci., 2024, 15, 16987
DOI: 10.1039/D4SC04619F

An amino acid-fortified in situ encapsulation strategy for constructing highly active enzyme@HOF biocomposites

Qiaoyi Cen, Huairou Zhu, Jiayin Huang, Dan Yan, Ningyi Zhong, Xinyuan Zhu, Fang Zhu, Guosheng Chen, Wei Yi, Siming Huang and Gangfeng Ouyang

Nanoscale, 2025, 17, 23473
DOI: 10.1039/D5NR03273C

Asymmetric heterogeneous catalysis using crystalline porous materials

Teng Li, Yan-Ting Chen, Xiao-Bin Zhang, Rong-Rong Du, Lin-Na Ma and Ya-Qian Lan

Chem. Soc. Rev., 2025, 54, 5912
DOI: 10.1039/D4CS00538D

Design of BODIPY functional ZIF-90 towards enhanced visible-light driven antibacterial performance

Dong-Mei Chen, Guang-Qi He, Qiu-Yun Chen, Gao-Ji Wang, Cheng Chen, Ying Dong and Ling-Ling Qu

New J. Chem., 2023, 47, 8152
DOI: 10.1039/D3NJ00397C

Design of enzyme@metal organic framework composites with thermo-responsivity for colourimetric detection of glucose

Muhammad Ali Tajwar, Cheng Cheng and Li Qi

Nanoscale, 2023, 15, 14055
DOI: 10.1039/D3NR03514J

Engineering a versatile nanoscale COF-based multienzyme loading strategy to enhance cancer therapy

Wen-Xiu Ren, Qing-Yun Huang, Jie Feng, Yue-Lu Tian, Ya-Ni Wu, Seeram Ramakrishna and Yu-Bin Dong

Mater. Chem. Front., 2025, 9, 1364
DOI: 10.1039/D4QM01129E

Enzyme-encapsulated metal–organic framework ZIF-8-mediated biosensor for ultrasensitive detection of urinary prostatic exosomal protein using a glucose meter

Mutu Lin, Qiaohong Wang, Yun Dai, Jinyuan Chen and Yiming Lin

RSC Adv., 2024, 14, 34848
DOI: 10.1039/D4RA05460A

Access to enzyme@porous organic framework biocomposites based on mechanochemical synthesis

Qing Chen, Zhi-Wei Li, Siming Huang, Guosheng Chen and Gangfeng Ouyang

RSC Mechanochem., 2025, 2, 336
DOI: 10.1039/D4MR00134F

ROS-scavenging biomaterials for periodontitis

Enni Chen, Tianyou Wang, Yuan Tu, ZhiYuan Sun, Yi Ding, Zhipeng Gu and Shimeng Xiao

J. Mater. Chem. B, 2023, 11, 482
DOI: 10.1039/D2TB02319A

Hydrogen-bonded organic frameworks: new horizons in biomedical applications

Dongqin Yu, Haochen Zhang, Jinsong Ren and Xiaogang Qu

Chem. Soc. Rev., 2023, 52, 7504
DOI: 10.1039/D3CS00408B

A molecular container providing supramolecular protection against acetylcholine hydrolysis

Yi-Long Lu, Jing Su, Jian-Wei Li and Wen-Rong Xu

Org. Biomol. Chem., 2024, 22, 1634
DOI: 10.1039/D4OB00024B

Enhancing carbon capture efficiency with a large-sized bionic jellyfish-carbonic anhydrase complex

Xing Zhu, Chenxi Du, Bo Gao and Bin He

Green Chem., 2023, 25, 9926
DOI: 10.1039/D3GC02804F

Recent progress in the synthesis and applications of covalent organic framework-based composites

Mingxuan Ma, Yonghao Yang, Zhonghua Huang, Fuhong Huang, Quanliang Li and Hongyu Liu

Nanoscale, 2024, 16, 1600
DOI: 10.1039/D3NR05797F

Amyloid detection in neurodegenerative diseases using MOFs

Ketan Maru, Amarendra Singh, Ritambhara Jangir and Komal Kumar Jangir

J. Mater. Chem. B, 2024, 12, 4553
DOI: 10.1039/D4TB00373J

In situ synthesis of bioorthogonally catalyzed drugs based on hydrogen-bonded organic frameworks for cancer therapy

Yan Wang, Luwen Zhang, Jiarui Qiao, Xianhao Wei, Tingyan Jiang, Junhe Ou and Maolin Pang

Inorg. Chem. Front., 2025, 12, 8626
DOI: 10.1039/D5QI01690H

Enzyme immobilization in a Ru(N^N)3-modified covalent organic framework for photoenzymatic cascade catalysis

Yanxia Wang, Bingchen Guo, Zhihua Chai, Ming Gao, Yanlin Li, Yang Yu and Shengli Huang

J. Mater. Chem. A, 2024, 12, 18537
DOI: 10.1039/D4TA02594F

A polymer deposition-mediated surface-charge reformation strategy: reversing the MOF biomineralization behavior

Yanbin Xu, Huangsheng Yang, Anlian Huang, Linjing Tong, Wei Huang, Guosheng Chen, Wei Yi, Siming Huang and Gangfeng Ouyang

Chem. Sci., 2024, 15, 19609
DOI: 10.1039/D4SC05935B

Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis

Weiqing Xu, Yu Wu, Wenling Gu, Dan Du, Yuehe Lin and Chengzhou Zhu

Chem. Soc. Rev., 2024, 53, 137
DOI: 10.1039/D3CS00767G

A charge-assisted hydrogen-bonded organic framework as a host platform for enzyme immobilization and robust biocatalysis

Jie Xu, Mengxuan Zuo, Hanyuan Zhang, Zhengyi Di and Cheng-Peng Li

Inorg. Chem. Front., 2025, 12, 2459
DOI: 10.1039/D4QI03044C

Covalent organic framework-derived CoRu nanoalloy doped macro–microporous carbon for efficient electrocatalysis

Huihui Zhao, Xinghao Zhang, Yaowen Zhang, Yuzhuang Song, Chen Li, Kang Liu and Dingxuan Ma

J. Mater. Chem. A, 2022, 10, 25272
DOI: 10.1039/D2TA08224A

Encapsulation of an enzyme-immobilized smart polymer membrane in a metal–organic framework for enhancement of catalytic performance

Rubina Jabeen, Nasir Ali, Muhammad Ali Tajwar, Yutong Liu, Dong Luo, Dan Li and Li Qi

J. Mater. Chem. B, 2024, 12, 3996
DOI: 10.1039/D4TB00162A

A biocatalytic reticular framework via enzyme immobilization for environmental pollutant monitoring

Rui Gao, Xiaoxue Kou, Jing Li, Siming Huang, Jiehao Yu, Zhi-Wei Li, Guosheng Chen and Gangfeng Ouyang

Chem. Commun., 2026, 62, 6503
DOI: 10.1039/D5CC07082A

Hierarchically mesoporous Ce-based MOFs with enhanced alkaline phosphatase-like activity for phosphorylated biomarker sensing

Rui Gao, Niru Ye, Xiaoxue Kou, Yujian Shen, Huangsheng Yang, Tong Wu, Siming Huang, Guosheng Chen and Gangfeng Ouyang

Chem. Commun., 2022, 58, 12720
DOI: 10.1039/D2CC04895G

Catalytic reduction of NAD(P)+ to NAD(P)H

Shunichi Fukuzumi, Yong-Min Lee and Wonwoo Nam

Chem. Commun., 2025, 61, 3271
DOI: 10.1039/D4CC06254J

A facile phase transformation-mediated mechanochemical assembly strategy facilitates the scale-up synthesis of enzyme@MOF biocomposites

Qing Chen, Lihong Guo, Xiaoxue Kou, Rui Gao, Ningyi Zhong, Anlian Huang, Rongwei He, Siming Huang, Fang Zhu, Guosheng Chen and Gangfeng Ouyang

Green Chem., 2025, 27, 5591
DOI: 10.1039/D5GC01222H

Aggregation behaviour of pyrene-based luminescent materials, from molecular design and optical properties to application

Xing Feng, Xiaohui Wang, Carl Redshaw and Ben Zhong Tang

Chem. Soc. Rev., 2023, 52, 6715
DOI: 10.1039/D3CS00251A

Exploring enzyme-immobilized MOFs and their application potential: biosensing, biocatalysis, targeted drug delivery and cancer therapy

Om Prakash, Deepika Verma and Poonam C. Singh

J. Mater. Chem. B, 2024, 12, 10198
DOI: 10.1039/D4TB01556H

Emerging enzyme-based nanocomposites for catalytic biomedicine

Minchao Liu, Hongyue Yu, Tiancong Zhao and Xiaomin Li

Dalton Trans., 2023, 52, 15203
DOI: 10.1039/D3DT01381B

Monitoring Enzyme Clustering in a Highly Crystalline Metal–Organic Framework by Small‐Angle Neutron Scattering

Xiaoliang Wang, Lilin He, Shuo Qian, Shengyi Su, Omar K. Farha and Shengqian Ma

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202522967

Recent progress in porous organic frameworks for electrochemical sensing of environmental pollutants

Zesen Zuo, Hao Zhang, Sanshuang Gao, Chunqiong Wang, Wen-Tong Chen and Guangzhi Hu

Journal of Environmental Chemical Engineering, 2024, 12, 113263
DOI: 10.1016/j.jece.2024.113263

Protein‐Integrated Hydrogen‐Bonded Organic Frameworks: Chemistry and Biomedical Applications

Lijuan Li, Tianyu Ma and Ming Wang

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202400926

Recent progress in antimicrobial strategies of controlled-release nanomaterials for secondary caries

Yiyi Wang, Xushuo Du, Yanmin Jia, Lu Qin, Fei Liu, Yingchun Cai and Suping Wang

Front. Cell. Infect. Microbiol., 2025, 15
DOI: 10.3389/fcimb.2025.1669643

Biomedical and environmental applications via nanobiocatalysts and enzyme immobilization

Yosri A. Fahim, Waleed Mahmoud Ragab, Ibrahim W. Hasani and Ahmed M. El-Khawaga

Eur J Med Res, 2025, 30
DOI: 10.1186/s40001-025-02782-2

Sequential release of photodynamic hybrid HOFs and CeO₂ via a bilayer dynamic SIS hydrogel for periodontitis therapy

Shiqing Ma, Yujia Xiao, Yang Yu, Xiaotong Liu, Jiayin Deng, Yilin Yang, Shiyu Yao, Beibei Ma, Yo Shibata, Jun Zhou, Bo Zhao and Yuzhu Mu

Chemical Engineering Journal, 2026, 535, 175582
DOI: 10.1016/j.cej.2026.175582

Lipase immobilization via dynamic defect-engineered ZIF-8: A bioactivity-enhanced platform for high-efficiency screening of herbal lipase inhibitors

Wenxiang Hu, Jiangyu Zong, Jiajun Gong, Rong Xue, Yangbin Lv, Biao Liu, Wenting Dai, Yajun Wang and Chu Chu

International Journal of Biological Macromolecules, 2026, 335, 149264
DOI: 10.1016/j.ijbiomac.2025.149264

Fabrication of Biomimetic Cascade Nanoreactor Based on Covalent Organic Framework Capsule for Biosensing

Dali Wei, Mingwei Li, Fengxiang Ai, Kun Wang, Nuanfei Zhu, Ying Wang, Daqiang Yin and Zhen Zhang

Anal. Chem., 2023, 95, 11052
DOI: 10.1021/acs.analchem.3c01308

Metal–Organic Framework‐Based Artificial Organelle Corrects Microenvironment Interference for Accurate Intratumoral Glucose Analysis

Weiqing Xu, Yu Wu, Yuling Xu, Xiaoli Cai, Wenling Gu and Chengzhou Zhu

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202308827

Pore‐Engineered Hydrogen‐Bonded Supramolecular Fluorosensor for Ultrasensitive Determination of Copper Ions

Haiting Chen, Haoquan Huang, Huiying Xu, Tong Wu, Yanbin Xu, Xiaomin Ma, Wei Yi, Guosheng Chen, Siming Huang and Gangfeng Ouyang

Small, 2024, 20
DOI: 10.1002/smll.202308716

Opportunities and Challenges of Metal–Organic Framework Micro/Nano Reactors for Cascade Reactions

Peng Wu, Yanhua Zhao, Xinglong Zhang, Yun Fan, Suoying Zhang, Weina Zhang and Fengwei Huo

JACS Au, 2023, 3, 2413
DOI: 10.1021/jacsau.3c00344

In-situ encapsulation and construction of Lac@HOFs/hydrogel composite for enhancing laccase stability and azo dyes decolorization efficiency

Xue Yang, Fei Shi, Xiaolei Su, Artur Cavaco-Paulo, Hongbo Wang and Jing Su

Carbohydrate Polymers, 2023, 320, 121157
DOI: 10.1016/j.carbpol.2023.121157

Encapsulating and stabilizing enzymes using hydrogen-bonded organic frameworks

Guosheng Chen, Siming Huang, Xiaomin Ma, Rongwei He and Gangfeng Ouyang

Nat Protoc, 2023, 18, 2032
DOI: 10.1038/s41596-023-00828-5

Recent advances in metal–organic framework/biomolecule hybrids for biomarker detection and bioimaging

Huafeng Wang, You Wu, Xinyi Wang, Fan Wu, Wenwen Tu, Wei Li and Zhihui Dai

TrAC Trends in Analytical Chemistry, 2026, 195, 118597
DOI: 10.1016/j.trac.2025.118597

Imparting insoluble-soluble property to Cyt c by immobilizing Cyt c in UCST-pH dual responsive polymer for highly sensitive detection of phenol

Yuanyuan Wang, Weimin Guan, Yulin Yang, Huiling Lan, Yu Wang, Yun Wang, Juan Han and Lei Wang

Colloids and Surfaces B: Biointerfaces, 2025, 245, 114344
DOI: 10.1016/j.colsurfb.2024.114344

Solution‐Mediated Photoreversible Switch Between 2D and 3D Hydrogen‐Bonded Organic Frameworks

Xiao Liu, Yingxiang Ye, Xu He, Qingyu Niu and Zhiqiang Li

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202508976

Pore Size Tunable Trypsin@ZIF-90 and Hydrogel Integrated Lateral Flow Point-of-Care Platform for ATP Detection

Wei Liu, Yuan Deng, Yuni Yuan, Stephen L. Ouyang, Qi Liu and Xiaoqing Chen

ACS Appl. Mater. Interfaces, 2023, 15, 21690
DOI: 10.1021/acsami.3c02888

Enzyme‐Embedded Amorphous Fluorescent Covalent Organic Frameworks for the Construction of Pesticides Biosensor

Yijie Wang, Mengxue Li, Changshun Su, Xiaomin Liu, Jinbei Wei, Peng Sun, Yuehe Lin, Geyu Lu, Hongxia Li, Zhenlin Xu and Xu Yan

Adv Funct Materials, 2026, 36
DOI: 10.1002/adfm.202519443

In situ co-encapsulation preparation of enhanced biocatalytic efficiency enzyme-mediator@covalent organic frameworks for continuous removal of pollutants

Qixuan Mu, Xinyue Li, Xiuxiu Li, Ruijun Li and Yibing Ji

Separation and Purification Technology, 2026, 382, 135869
DOI: 10.1016/j.seppur.2025.135869

Nanomaterials for co‐immobilization of multiple enzymes

Jingyu Zhang, Jonathan F. Lovell, Jiafu Shi and Yumiao Zhang

BMEMat, 2025, 3
DOI: 10.1002/bmm2.12080

Pushing the boundaries: The path of mechanosynthesis toward the assembly of supramolecular organic frameworks

Danilo Marchetti, Riccardo Testa, Alessandro Pedrini and Chiara Massera

Coordination Chemistry Reviews, 2026, 555, 217600
DOI: 10.1016/j.ccr.2026.217600

Direct Imaging of Protein Clusters in Metal–Organic Frameworks

Yu Liu, Shitong Cui, Wenjun Ma, Yibo Wu, Ruobing Xin, Yunxiu Bai, Zhuo Chen, Jianhong Xu and Jun Ge

J. Am. Chem. Soc., 2024, 146, 12565
DOI: 10.1021/jacs.4c01483

Advances in porous organic cage composites for next-generation water remediation and desalination

Divya Bajpai Tripathy, Pooja Agarwal and Subhalaxmi Pradhan

Materials Research Bulletin, 2026, 201, 114113
DOI: 10.1016/j.materresbull.2026.114113

Bio‐Templated Chiral Zeolitic Imidazolate Framework for Enantioselective Chemoresistive Sensing

Minkyu Kim, Moon Jong Han, Hansol Lee, Paraskevi Flouda, Daria Bukharina, Kellina J. Pierce, Katarina M. Adstedt, Madeline L. Buxton, Young Hee Yoon, William T. Heller, Srikanth Singamaneni and Vladimir V. Tsukruk

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202305646

Polyhedral oligomeric silsesquioxane-modulated mesoporous amorphous bimetallic organic frameworks for the efficient isolation of immunoglobulin G

Lan Liu, Kai Xie, Yuheng Wang, Haoran Wang, Jinyi Wang, Yuting Zhuang and Yue Zhang

Talanta, 2025, 282, 126949
DOI: 10.1016/j.talanta.2024.126949

Structural and Functional Insights into the Biomineralized Zeolite Imidazole Frameworks

Anlian Huang, Linjing Tong, Xiaoxue Kou, Rui Gao, Zhi-Wei Li, Siming Huang, Fang Zhu, Guosheng Chen and Gangfeng Ouyang

ACS Nano, 2023, 17, 24130
DOI: 10.1021/acsnano.3c09118

Monitoring Enzyme Clustering in a Highly Crystalline Metal–Organic Framework by Small‐Angle Neutron Scattering

Xiaoliang Wang, Lilin He, Shuo Qian, Shengyi Su, Omar K. Farha and Shengqian Ma

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202522967

Tailoring Artificial Hydration Microenvironments in Covalent Organic Frameworks for Enhanced Enzymatic Catalysis in Organic Media

Chunyan Xing, Zhenjie Mu, Bixiao Li, Jianwei Yang, Xiao Feng, Yuanyuan Zhang and Bo Wang

J. Am. Chem. Soc., 2025, 147, 30084
DOI: 10.1021/jacs.5c07600

Biomaterials and biosensing technologies in the detection and removal of pesticide residues: Current trends and future prospects

Zhuliang Chen, Ruibing Feng, Qiuzhong Zhou, Xinya Zhang, Yu Fan, Dafeng Fang, Rongbo Zheng, Wei Zhang, Zhaoyang Lu, Jincan Chen, Qing-Wen Zhang, Changlong Jiang, Peng Li, Hua Yu and Guodong Li

Coordination Chemistry Reviews, 2026, 547, 217110
DOI: 10.1016/j.ccr.2025.217110

Anion Bridged One‐Dimensional Copper‐Based Metal Organic Frameworks as Peroxidase Mimics for Glucose Detection in Apple Fruits

Yuzhang Yang, Minji Li, Yunqian Gong, Xingliang Li, Jia Zhou, Qinping Wei and Junke Zhang

Applied Organom Chemis, 2025, 39
DOI: 10.1002/aoc.7957

Development of TiO2/Hemin@MAF-7 composites for Photo-Fenton-like degradation of tetracycline antibiotics and cyanobacteria

Lina Yang, Suimin Deng, Hailing Liu, Xiangfeng Wang, Pingye Deng, Yuan Liu and Mengxia Xie

Journal of Molecular Structure, 2025, 1328, 141328
DOI: 10.1016/j.molstruc.2025.141328

Dissipative enzymatic catalysis-driven modulation of coordination mode and cation valence in MOFs responsive for dual-modality enzyme assay

Yi Yang, Licheng Yu, Xiaowen Jiang, Yijun Li, Xiwen He, Langxing Chen and Yukui Zhang

Sensors and Actuators B: Chemical, 2024, 401, 135090
DOI: 10.1016/j.snb.2023.135090

<italic>In situ</italic> assembly of enzyme@hydrogen-bonded organic frameworks composites

Wei Huang, Huangsheng Yang, Siming Huang, Guosheng Chen and Gangfeng Ouyang

Sci. Sin.-Chim, 2024, 54, 1576
DOI: 10.1360/SSC-2024-0107

Co-immobilization of LAAO and Pt NPs in HOFs: An enzyme-metal coupled catalysis for enhancing the one-pot synthesis of α-keto acid

Lijun Yang, Tiantian Zhou, Zhiyi Zhang, Wei Qi and Mengfan Wang

International Journal of Biological Macromolecules, 2025, 311, 143899
DOI: 10.1016/j.ijbiomac.2025.143899

Tailored Metal‐Organic Framework‐Based Enzyme Hybrids: Immobilization Strategies, Improved Performance, and Biological Applications

Xiang Xu, Jiacheng Wan, Jun Sun, Lina Wu and Jianping Lei

Small Science, 2025, 5
DOI: 10.1002/smsc.202500222

In Situ Synthesis of Enzyme-Confined Crystalline Porous Frameworks: A Triad of Linkage, Pore, and Interface Engineering

Guosheng Chen, Siming Huang, Xiaomin Ma, Jia-Wei Wang and Gangfeng Ouyang

Acc. Chem. Res., 2026
DOI: 10.1021/acs.accounts.6c00073

Nanozyme engineering in structurally explicit framework: Design mechanisms and biosensing applications

Yanbin Xu, Anlian Huang, Wei Yi, Guosheng Chen, Siming Huang and Gangfeng Ouyang

Coordination Chemistry Reviews, 2024, 500, 215517
DOI: 10.1016/j.ccr.2023.215517

Investigating the 3D coupling of mechanical and electrical effects on porous materials via Green’s function

Muzammal Hameed Tariq and Yue-Ting Zhou

Mechanics Research Communications, 2025, 144, 104381
DOI: 10.1016/j.mechrescom.2025.104381

Unlocking of Hidden Mesopores for Enzyme Encapsulation by Dynamic Linkers in Stable Metal‐Organic Frameworks

Meng Qiao, Youcong Li, Yanqi Li, Mengting Chang, Xing Zhang and Shuai Yuan

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202409951

Integrating Enzymes with Reticular Frameworks To Govern Biocatalysis

Linjing Tong, Siming Huang, Guosheng Chen and Gangfeng Ouyang

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202421192

Biocatalytic hydrogen-bonded organic frameworks: Design and biomedical applications

Dongqin Yu, Ke Zhang, Chao Qi and Kaiyong Cai

Biomaterials, 2026, 327, 123734
DOI: 10.1016/j.biomaterials.2025.123734

Merging MOF Chemistry & Biocatalysis: A Perspective for Achieving Efficient Organic Synthetic Processes and Applications in the Chemical Industry?

Harald Gröger, Adil Allahverdiyev, Jianing Yang and Johannes Stiehm

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202304794

Ultrasound/GSH dual responsive ZIF-8-GOx@Cu-PDA@liposome-L-arginine nanoparticles for ion interference/starvation/gas synergistic tumor therapy

Yingpei Yao, Tian Zhang, Yunzhu Wang, Dong Cen, Yike Fu and Xiang Li

Nano Research, 2025, 18, 94907373
DOI: 10.26599/NR.2025.94907373

Customized anion-exchange covalent organic frameworks for efficient extraction of natural products

Sainan Zhang, Yunlong Zheng, Wentao Sun, Heng Hu, Chun Li, Zhenjie Zhang and Yao Chen

Separation and Purification Technology, 2024, 342, 127072
DOI: 10.1016/j.seppur.2024.127072

DNA-directed assembly of core-satellite MOF structures for spatially compartmentalized multi-enzyme cascade catalysis

Wanning Gao, Shengyuan Shi, Youcong Li, Fangyuan Liu, Yudi Cheng, Jie Zheng, Meng Qiao, Shuai Yuan and Xing Zhang

Chemical Engineering Journal, 2026, 529, 173137
DOI: 10.1016/j.cej.2026.173137

Incorporation of porous organic cages in the shell of organosilica network capsules for enzyme immobilization

Jiafang Wang, Bingchen Guo, Boyu Zhang, Yexin Dai, Yiran Cheng, Shilong Chang, Zhenhua Wu, Shujing Zhang, Dong Yang, Jiafu Shi and Zhongyi Jiang

Chemical Engineering Science, 2026, 325, 123413
DOI: 10.1016/j.ces.2026.123413

Compartmentalized Nano-MOFs as Co-delivery Systems for Enhanced Antitumor Therapy

Wenxiu Duan, Lifeng Hang, Yinchu Ma, Qin Wang, Xinfeng Tang, Wei Jiang, Yi Wu, Weifu Lv and Yucai Wang

ACS Appl. Mater. Interfaces, 2023, 15, 39039
DOI: 10.1021/acsami.3c04296

Fabricating Polymeric Micelles with Enrichment and Cavity Effect for In Situ Enzyme Imobilization from Natural Biosystems

Yuanyuan Wang, Huiling Lan, Yulin Yang, Qing Man, Yuanyuan Liu, Juan Han, Weimin Guan, Yun Wang and Lei Wang

Biomacromolecules, 2024, 25, 5873
DOI: 10.1021/acs.biomac.4c00557

Cobalt MOF-hybridized nanozyme catalysts breaking pH limitations for boosted chlorpyrifos sensing performance

Ruiqi Zou, Junxiao Shi, Qi Lu, Chunyan Sun, Haiqing Ye, Xu Yan, Fangjie Tian and Hongxia Li

Food Chemistry, 2025, 475, 143399
DOI: 10.1016/j.foodchem.2025.143399

Ru Nanoparticles and Lipase on Metal–Organic Frameworks for the Reductive Esterification of Aldehydes

Yuxuan Zhou, Fang Gao, Youting Wang, Fan Yu, Rui Zhu and Liang Zhang

ACS Appl. Nano Mater., 2026, 9, 3779
DOI: 10.1021/acsanm.5c05517

Stimuli-responsive proton conduction in crystalline porous materials

Xiao-Min Li, Dongbo Liu, Junchao Jia, Banglin Chen and Junkuo Gao

Coordination Chemistry Reviews, 2025, 544, 216953
DOI: 10.1016/j.ccr.2025.216953

Covalent Organic Frameworks for Enzyme Immobilization: Synthesis, Pore Structure Modification, and Applications

Yongheng Shi, Lingmei Dai, Dehua Liu and Wei Du

ACS Materials Lett., 2025, 7, 3320
DOI: 10.1021/acsmaterialslett.5c00905

On the Importance of Squaramide and Squarate Derivatives as Metal–Organic Framework Building Blocks

Catalina Nicolau, María de las Nieves Piña, Jeroni Morey and Antonio Bauzá

Crystals, 2025, 15, 294
DOI: 10.3390/cryst15040294

Synergistic bimetallic competition and defect engineering in hierarchically porous MOF-enzyme composites to enhance the enzymatic synthesis of rare ginsenoside CK

Mengmeng Zhang, Xinjian Huang, Wenfei Shao, Runze Li, Qianqian Shen, Zhansheng Wu and Chun Li

International Journal of Biological Macromolecules, 2026, 357, 151512
DOI: 10.1016/j.ijbiomac.2026.151512

A one-two punch strategy for diabetic wound management based on an antibiotic-hybrid biomineralized iron sulfide nanoparticle

Shuangpiao Deng, Kaixin Ou, Chenyu Zhang, Daojing Yuan, Xiaowen Cai, Fengtan Li, Xuetao Wang, Jing Yin, Chuanshan Xu, Yanli Li and Teng Gong

Acta Biomaterialia, 2024, 181, 333
DOI: 10.1016/j.actbio.2024.04.027

Enzyme-based electrochemical biosensor for antimonite detection in water

Rui Pei, Li Ye and Chuanyong Jing

Biosensors and Bioelectronics, 2023, 229, 115244
DOI: 10.1016/j.bios.2023.115244

Design, Synthesis, and Application of Immobilized Enzymes on Artificial Porous Materials

Lu Ran, Yuan Lu, Li Chen, Mengru He and Zhangshuang Deng

Advanced Science, 2025, 12
DOI: 10.1002/advs.202500345

Enhancing Chymotrypsin Activity and Stability of Capillary Immobilized Enzyme Microreactors Using Zeolitic Imidazolate Frameworks as Encapsulation Materials

Shuyi Zhang, Yijia Gan, Han Wang, Xingyi Qi, Ping Su, Jiayi Song and Yi Yang

Anal. Chem., 2024, 96, 9228
DOI: 10.1021/acs.analchem.4c01425

Spin Sensor-Integrated Covalent Organic Frameworks Reveal the Effect of Host–Guest Interactions on the Catalytic Activity of Immobilized Enzymes

Jingru Feng, Xiaohui Liu, Siming Huang, Hankang Zhong, Can Xue, Guosheng Chen, Xiantai Zhou and Gangfeng Ouyang

J. Am. Chem. Soc., 2025, 147, 28912
DOI: 10.1021/jacs.5c06528

Enzyme–inspired coordination chemistry in confined and interfacial microenvironments: Insights from MOFs and MXenes

Brij Mohan, Virender Virender, Rakesh Kumar Gupta, M.Fátima C. Guedes da Silva, Armando J.L. Pombeiro, Yuchen Qiao and Xuemei Yang

Coordination Chemistry Reviews, 2026, 561, 217926
DOI: 10.1016/j.ccr.2026.217926

Sustainable hybrid photo/electro-enzyme systems for CO2 conversion

Wanrong Dong, Jinde Cai, Qimei Sun, Likun Luan, Xiuling Ji, Shaojuan Zeng and Yuhong Huang

Green Chemical Engineering, 2025, 6, 518
DOI: 10.1016/j.gce.2025.06.006

A Synergetic Pore Compartmentalization and Hydrophobization Strategy for Synchronously Boosting the Stability and Activity of Enzyme

Lihong Guo, Rongwei He, Guosheng Chen, Huangsheng Yang, Xiaoxue Kou, Wei Huang, Rui Gao, Shuyao Huang, Siming Huang, Fang Zhu and Gangfeng Ouyang

J. Am. Chem. Soc., 2024, 146, 17189
DOI: 10.1021/jacs.4c03286

Engineering hydrogen-bonded organic frameworks for efficient enzyme encapsulation and diagnostic applications

Bing Liu, Jiahui Cheng, Tingyuan Zheng, Sapana Jadoun, Parashuram Kallem, Garima Tripathi, Rakesh Kumar Gupta, Zhongquan Li and Di Sun

Coordination Chemistry Reviews, 2026, 558, 217798
DOI: 10.1016/j.ccr.2026.217798

Albumin Corona‐Coated Nanoscale Metal–Organic Framework for Enzyme‐Mediated Cascade Metabolization of Uric Acid in Hyperuricemia

Mingchen Lv, Jiaxi Xu, Ran Chen, Wei Hu, Yuxiao Zhou, Min Sun, Zhen Fan and Jianzhong Du

Small, 2025, 21
DOI: 10.1002/smll.202412612

Recent advances of multivalent metal nanozymes in analysis and detection

Zhao Li, Weidan Na, Chuangeng Tian, Jianguo Dong, Lin Tian, Ming Ma, Tognxiang Li and Yu Zhang

Chemical Engineering Journal, 2025, 526, 171146
DOI: 10.1016/j.cej.2025.171146

Integrating Enzymes with Reticular Frameworks To Govern Biocatalysis

Linjing Tong, Siming Huang, Guosheng Chen and Gangfeng Ouyang

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202421192

Electro‐Driven Multi‐Enzymatic Cascade Conversion of CO2 to Ethylene Glycol in Nano‐Reactor

Likun Luan, Yingfang Zhang, Xiuling Ji, Boxia Guo, Shaoyu Song, Yuhong Huang and Suojiang Zhang

Advanced Science, 2024, 11
DOI: 10.1002/advs.202407204

Tuning Microenvironment over Metal–Organic Frameworks for Efficient Enzyme Immobilization and Sensitive Immunoassay

Guo Chen, Weiqing Xu, Wenling Gu and Chengzhou Zhu

Anal. Chem., 2025, 97, 16019
DOI: 10.1021/acs.analchem.5c03157

Bifunctional COF-templated synthesis of immobilized enzyme catalysts for efficient bioconversion

Yang Yang, Jiafu Shi, Yu Chen, Shihao Li, Han Wang, Wenping Li, Shusong Liu, Xinyu Mao, Hong Wu and Zhongyi Jiang

Chemical Engineering Science, 2025, 313, 121717
DOI: 10.1016/j.ces.2025.121717

Encapsulating β-Glucosidase within Nanoporous ZIF-8-Cu Nanoparticles Enables High-Temperature Activity

Rui Jiao, Yanming Wang, Yuxia Pang, Dongjie Yang, Hongming Lou and Xueqing Qiu

ACS Appl. Nano Mater., 2023, 6, 17902
DOI: 10.1021/acsanm.3c03168

Spatial distribution and proximity effect-dependent multi-enzyme cascades catalysis operating in dendritic mesoporous silica nanoparticles

Hongxia Yang, Xuefang Zhu, Kai Hua, Fengzhong Yuan, Jing Zhang and Yucheng Jiang

Molecular Catalysis, 2023, 547, 113290
DOI: 10.1016/j.mcat.2023.113290

The synthesis, characterization and applications of metal-organic frameworks

Ming-Liang Gao, Tianwei Xue, Jiangnan Li, Lixia Guo, He-Qi Zheng, Jiangfeng Lu, Li Peng, Sihai Yang, Yuanjing Cui, Guodong Qian, Gang Xu and Hai-Long Jiang

Chin. Sci. Bull., 2026, 71, 370
DOI: 10.1360/TB-2024-1353

A New Phosphorylated Protein Analysis Strategy based on Trypsin Encapsulated in Metal–Organic Frameworks with High Efficiency and a Simplified Workflow

Wenkang Zhang, Xingyi Qi, Zhuo Mi, Han Wang, Shaojuan Lv, Yongfeng Song, Ping Su, Jiayi Song and Yi Yang

Anal. Chem., 2025, 97, 7456
DOI: 10.1021/acs.analchem.5c00324

Integration of Multiple Enzymes Within Hydrogen‐Bonded Organic Frameworks for Efficient Cascade Photocatalytic CO2‐to‐Methanol Conversion in Water

Jiakang Tang, Yifei Lei, Qingxuan Tang, Shixing Lei, Qiao‐Yan Qi, Zhan‐Ting Li and Jia Tian

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202516599

Protein‐Integrated Hydrogen‐Bonded Organic Frameworks: Chemistry and Biomedical Applications

Lijuan Li, Tianyu Ma and Ming Wang

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202400926

Hydrogen-bonded supramolecular crystal: A manual exoskeleton for bioentity

Anlian Huang, Huangsheng Yang, Siming Huang, Guosheng Chen and Gangfeng Ouyang

Matter, 2023, 6, 2635
DOI: 10.1016/j.matt.2023.06.002

Dynamic and transformable Cu12 cluster-based C-H···π-stacked porous supramolecular frameworks

Chengkai Zhang, Zhi Wang, Wei-Dan Si, Hongxu Chu, Lan Zhou, Tong Li, Xian-Qiang Huang, Zhi-Yong Gao, Mohammad Azam, Chen-Ho Tung, Ping Cui and Di Sun

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-42201-w

Bio‐Templated Chiral Zeolitic Imidazolate Framework for Enantioselective Chemoresistive Sensing

Minkyu Kim, Moon Jong Han, Hansol Lee, Paraskevi Flouda, Daria Bukharina, Kellina J. Pierce, Katarina M. Adstedt, Madeline L. Buxton, Young Hee Yoon, William T. Heller, Srikanth Singamaneni and Vladimir V. Tsukruk

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202305646

Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis

Kun-Yu Wang, Jiaqi Zhang, Yu-Chuan Hsu, Hengyu Lin, Zongsu Han, Jiandong Pang, Zhentao Yang, Rong-Ran Liang, Wei Shi and Hong-Cai Zhou

Chem. Rev., 2023, 123, 5347
DOI: 10.1021/acs.chemrev.2c00879

Two-Dimensional Acid–Base Hydrogen-Bonded Organic Framework toward a Highly Conductive Proton Exchange Membrane

Chen Wang, Zhirong Yang, Wenjia Wu, Chongchong Chen, Yifan Li, Runnan Zhang, Wenpeng Li, Kun Dai and Jingtao Wang

Chem. Mater., 2024, 36, 8255
DOI: 10.1021/acs.chemmater.4c01043

Enhancing thermal stability of cytochrome c enzyme via IR-MOF-74-VI encapsulation: Insights from molecular dynamics simulations

Zahra Chavoshpour-Natanzi and Nahid Farzi

Surfaces and Interfaces, 2025, 59, 105933
DOI: 10.1016/j.surfin.2025.105933

Controllable synthesis of hydrogen-bonded organic framework encapsulated enzyme for continuous production of chiral hydroxybutyric acid in a two-stage cascade microreactor

Danyang Zhao, Qiangqiang Xue, Yujun Wang and Guangsheng Luo

Chinese Journal of Chemical Engineering, 2025, 77, 175
DOI: 10.1016/j.cjche.2024.09.020

Encapsulation of lipase in zeolitic imidazolate framework-8 induced by polyethyleneimine to form a honeycomb structure with enhanced activity

Meiai Huang, Zhuolin Luo, Qian Zhang, Quan Zeng, Bizhu Sun, Hao Li, Panliang Zhang and Kewen Tang

International Journal of Biological Macromolecules, 2024, 254, 127787
DOI: 10.1016/j.ijbiomac.2023.127787

Chiral metal-organic frameworks materials for racemate resolution

Qingsong Cheng, Qian Ma, Hebing Pei, Hao Liang, Xuejiao Zhang, Xuening Jin, Nijuan Liu, Ruibin Guo and Zunli Mo

Coordination Chemistry Reviews, 2023, 484, 215120
DOI: 10.1016/j.ccr.2023.215120

Lipase-based HKUST-1 (Cu) biocomposites as chiral stationary phase for enantiomer separation in capillary electrochromatography

Mengxue Tang, Jiale Zhang, Qixuan Mu, Keyan Chen and Yibing Ji

Analytica Chimica Acta, 2026, 1389, 345102
DOI: 10.1016/j.aca.2026.345102

One-step reagentless colorimetric analysis platform of biomineralized Ce-UiO-66 for universal detection of biomarkers

Zhixiong Guo, Zhimin Tian and Yongquan Qu

Sensors and Actuators B: Chemical, 2023, 397, 134705
DOI: 10.1016/j.snb.2023.134705

3D Visualization of Proteins within Metal–Organic Frameworks via Ferritin‐Enabled Electron Microscopy

Rakia Dhaoui, Saira L. Cazarez, Li Xing, Elmira Baghdadi, Justin T. Mulvey, Nehal S. Idris, Paul J. Hurst, M. Paula Vena, Giuseppe Di Palma and Joseph P. Patterson

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202312972

Biomimetic metal–organic frameworks for biological applications

Renzeng Chen, Xianheng Chen, Yuanbo Wang and Bo Wang

Trends in Chemistry, 2023, 5, 460
DOI: 10.1016/j.trechm.2023.03.007

Chiral nanoenzymes: synthesis and applications

Xiaohui Niu, Jianying Zhang, Mei Yuan, Yongqi Liu, Yuewei Wang, Hongxia Li and Kunjie Wang

Microchim Acta, 2024, 191
DOI: 10.1007/s00604-024-06803-5

Integrating Vitamin B12 with Immobilized Lipase for a Recyclable Chemoenzymatic Cascade

Shan Wang, Xiankun Wu, René Hübner and Changzhu Wu

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.70215

Fertile ground for homeostatic reformation: Engineered release platforms for enhanced regenerative outcomes

Pei Wang, Yan Gong, Xiansong Wang and Xiaoxi Lin

Journal of Drug Delivery Science and Technology, 2025, 106, 106740
DOI: 10.1016/j.jddst.2025.106740

Reticular Chemistry for Enhancing Bioentity Stability and Functional Performance

Mengchu Feng, Chunyan Xing, Yehao Jin, Xiao Feng, Yuanyuan Zhang and Bo Wang

J. Am. Chem. Soc., 2024, 146, 32883
DOI: 10.1021/jacs.4c09259

Homogeneous Catalysis and Enzyme Mimics Catecholase, Phenoxazine Synthase and Tyrosinase Pathways

Oussama Riouchi, Mohamed El Boutaybi, Zakariae Abbaoui and Rachid Touzani

BIO Web Conf., 2026, 212, 01009
DOI: 10.1051/bioconf/202621201009

Ordered heterogeneity in dual-ligand MOF to enable high electrochemiluminescence efficiency for bioassay with DNA triangular prism as signal switch

Yan-Qi Xue, Ni Liao, Yan Li, Wen-Bin Liang, Xia Yang, Xia Zhong and Ying Zhuo

Biosensors and Bioelectronics, 2022, 217, 114713
DOI: 10.1016/j.bios.2022.114713

A 3D ordered hierarchical crystalline porous organic salt for large-sized enzyme immobilization

Jinman Wang, Guolong Xing, Yu Zhao, Jinming Zhou, Bo Song, Li-Hua Chen, Weidong Zhu, Bao-Lian Su and Teng Ben

Chem Synth, 2024, 4
DOI: 10.20517/cs.2024.24

Covalent organic framework-immobilized enzymes: A robust engineered catalytic platform for diverse applications

Fengyi Yang, Pengye Zhang, Jiafu Qu, Yahui Cai, Xiaogang Yang, Chang Ming Li and Jundie Hu

Nano Energy, 2025, 136, 110682
DOI: 10.1016/j.nanoen.2025.110682

Enzyme@bismuth-ellagic acid: a versatile platform for enzyme immobilization with enhanced acid-base stability

Junyang Xu, Guanhua Liu, Ying He, Liya Zhou, Li Ma, Yunting Liu, Xiaobing Zheng, Jing Gao and Yanjun Jiang

Front. Chem. Sci. Eng., 2023, 17, 784
DOI: 10.1007/s11705-022-2278-4

Smart chemistry and applied perceptions of enzyme-coupled nano-engineered assemblies to meet future biocatalytic challenges

Ayesha Anwar, Muhammad Imran and Hafiz M.N. Iqbal

Coordination Chemistry Reviews, 2023, 493, 215329
DOI: 10.1016/j.ccr.2023.215329

Protein-Templated Ultrasmall Pt Nanocluster in Adenosine ATP-Responsive MOF Nanoarchitectonics for Ultrasensitive Point-of-Care Detection

Huan Jin, Huangsheng Yang, Wei Huang, Ningyi Zhong, Yanbin Xu, Anlian Huang, Xiaohui Liu, Siming Huang, Fang Zhu, Guosheng Chen and Gangfeng Ouyang

Anal. Chem., 2025, 97, 19982
DOI: 10.1021/acs.analchem.5c04930

Covalent organic frameworks as multifunctional nanoplatforms for precise cancer therapy: design principles, applications, and future perspectives

Baogang Zhang, Xi Su, Ju Kang and Long Chen

Coordination Chemistry Reviews, 2026, 549, 217250
DOI: 10.1016/j.ccr.2025.217250

Two-Site Enhanced Porphyrinic Metal–Organic Framework Nanozymes and Nano-/Bioenzyme Confined Catalysis for Colorimetric/Chemiluminescent Dual-Mode Visual Biosensing

Huining Chai, Yujie Li, Kun Yu, Zhishuang Yuan, Jing Guan, Weiqiang Tan, Jiping Ma, Xueji Zhang and Guangyao Zhang

Anal. Chem., 2023, 95, 16383
DOI: 10.1021/acs.analchem.3c03872

Recent Progress in Covalent Organic Frameworks (COF)-Based Hybrid Materials for Environmental Monitoring: a Review

Tahir, Muhammad Balal Arain, Abdul Niaz and Mustafa Soylak

Analytical Letters, 2026, 1
DOI: 10.1080/00032719.2026.2654736

Nanozymes for biomedical applications

Xin Wang, Yutong Fang and Ying-Wei Yang

APL Materials, 2024, 12
DOI: 10.1063/5.0237766

Metal–Organic Framework‐Based Artificial Organelle Corrects Microenvironment Interference for Accurate Intratumoral Glucose Analysis

Weiqing Xu, Yu Wu, Yuling Xu, Xiaoli Cai, Wenling Gu and Chengzhou Zhu

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202308827

Porphyrin-engineered metal−organic frameworks for photo/electrochemical sensing: Preparation and mechanisms

Zhishuang Yuan, Huining Chai, Yi Huang, Ziyan Zhang, Weiqiang Tan, Yingjie Sun, Jiping Ma and Guangyao Zhang

Coordination Chemistry Reviews, 2025, 527, 216385
DOI: 10.1016/j.ccr.2024.216385

Developing Covalent Organic Framework Biocatalysts through Enzyme Encapsulation

Rui Gao, Xiaoxue Kou, Siming Huang, Guosheng Chen and Gangfeng Ouyang

ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400339

Postmethylation of BODIPY-Based Covalent Organic Framework Nanostructures for Improving Photothermal and Photodynamic Bacterial Inactivation

Lin Ma, Guoli Sun, Hongmei Kong, Jing Wang, Yingying Ma, Zhengxuan Pan, Bin Wang and Baolong Zhou

ACS Appl. Nano Mater., 2024, 7, 21471
DOI: 10.1021/acsanm.4c03235

Microenvironmental Self‐Optimizing HOFs Biocatalysts for Boosting Disulfidptosis‐Mediated Antitumor Immunotherapy

Ke Zhang, Xiaotong Lu, Yuhong Zhuo, Ya Li, Ting Yao, Yusi Li, Wei Yao, Dongqin Yu, Chao Qi and Kaiyong Cai

Adv Funct Materials, 2026, 36
DOI: 10.1002/adfm.202512644

Protocol for mechanochemistry-guided assembly strategy for enzyme encapsulation using covalent organic frameworks

Rui Gao, Xiaoxue Kou, Rongwei He, Yujiang Shen, Lihong Guo, Hao Wang, Siming Huang, Guosheng Chen and Gangfeng Ouyang

STAR Protocols, 2023, 4, 102421
DOI: 10.1016/j.xpro.2023.102421

Hierarchical enzyme immobilization: encapsulating mesoporous polymer nanospheres in covalent organic frameworks for enhanced reusability and stability

Mingran Ma, Shuang Hou, Fangshuo Yu, Rong Chen, Xiangfei Jin and Weiyang Shen

Microchim Acta, 2026, 193
DOI: 10.1007/s00604-026-08046-y

Spatial Localization of Two Enzymes at Pickering Emulsion Droplet Interfaces for Cascade Reactions

Ke Li, Houbing Zou, Rammile Ettelaie, Jingxia Zhang and Hengquan Yang

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202300794

Polyoxometalates-based functional materials in chemiresistive gas sensors and electrochemical sensors

Li Chen, Jing Geng, Zheng Guo and Xing-Jiu Huang

TrAC Trends in Analytical Chemistry, 2023, 167, 117233
DOI: 10.1016/j.trac.2023.117233

Frontiers in design and applications of biomacromolecule@COFs composites

Wenhai Feng, Can Guo, Rui Xu, Zhi Yang, Haifu Zhang, Luanhua Zhou, Hai-Ning Wang, Yifa Chen and Ya-Qian Lan

Coordination Chemistry Reviews, 2024, 515, 215965
DOI: 10.1016/j.ccr.2024.215965

Enzyme‐Engineered Metal‐Organic Frameworks for the Construction of Organophosphorus Pesticide Biosensor

Hongxia Li, Qi Lu, Junxiao Shi, Xiaoguang Zhang, Peng Sun, Xu Yan and Geyu Lu

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202309383

A novel carboxylesterase HylD3 with efficient hydrolytic activity against phthalate esters: Enzymatic characterization, catalytic mechanism, and recycling catalysis through immobilization

Jinghui Lai, Xinyue Zhang, Jie Deng, Xianing Wang, Hongyun Lu, Enxiang Zong, Mingquan Huang, Zhiguo Huang, Youqiang Xu and Baoguo Sun

Bioresource Technology, 2026, 442, 133731
DOI: 10.1016/j.biortech.2025.133731

MOF and MOF-derived composites for flexible energy storage devices

Yingying Wang, Tao Pan, Guoqiang Yuan, Qing Li and Huan Pang

Composites Communications, 2024, 52, 102144
DOI: 10.1016/j.coco.2024.102144

Metal-pyrimidine nanocubes immobilized enzymes with pH-switchable multienzyme-like activity for broad-pH-responsive sensing assay for organophosphorus pesticides

Changbao Gong, Bo Chen, Yifei Xing and Huimin Zhao

Journal of Hazardous Materials, 2024, 463, 132849
DOI: 10.1016/j.jhazmat.2023.132849

Construction of heterogeneously connected cobalt-based MOF-COF and its application in highly selective separation of trace lead ions

Wei-Tao Li, Shuo Zhang, Huanhuan Guo, Ling Yu and Cuijuan Xing

Talanta, 2024, 278, 126546
DOI: 10.1016/j.talanta.2024.126546

Hydrogen-Bonded Supramolecular Nanotrap Enabling the Interfacial Activation of Hosted Enzymes

Siming Huang, Jiansheng Li, Yuhong Lin, Linjing Tong, Ningyi Zhong, Anlian Huang, Xiaomin Ma, Shuyao Huang, Wei Yi, Yong Shen, Guosheng Chen and Gangfeng Ouyang

J. Am. Chem. Soc., 2024, 146, 1967
DOI: 10.1021/jacs.3c09647

Construction and Application of a Pepsin‐Functionalized Covalent Organic Framework with Prominent Chiral Recognition Ability

Jiale Zhang, Xue Liu, Qixuan Mu, Ruijun Li and Yibing Ji

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202303827

Recent Advances in Multifunctional Reticular Framework Nanoparticles: A Paradigm Shift in Materials Science Road to a Structured Future

Maryam Chafiq, Abdelkarim Chaouiki and Young Gun Ko

Nano-Micro Lett., 2023, 15
DOI: 10.1007/s40820-023-01180-9

Novel biocatalysts based on enzymes in complexes with nano- and micromaterials

M. G. Holyavka, S. S. Goncharova, Y. A. Redko, M. S. Lavlinskaya, A. V. Sorokin and V. G. Artyukhov

Biophys Rev, 2023, 15, 1127
DOI: 10.1007/s12551-023-01146-6

Hierarchically Micro-, Meso-, and Macro-Porous MOF Nanosystems for Localized Cross-Scale Dual-Biomolecule Loading and Guest-Carrier Cooperative Anticancer Therapy

Qiaomei Ke, Ke Jiang, Hong Li, Ling Zhang and Banglin Chen

ACS Nano, 2024, 18, 21911
DOI: 10.1021/acsnano.4c02288

Hydrophobic Ionic Liquid Gel Microspheres as Bi‐Component Carriers with a Liquid Phase to Immobilize Enzymes for Enhanced Performance

Chuxuan Ben, Shujie Zhao, Qiong Wu, Hongjiang He, Meng Yu, Dong Liu, Dongqing He, Xi‐Ming Song and Zhining Song

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202407913

Core‐Shell Reactor Partitioning Enzyme and Prodrug by ZIF‐8 for NADPH‐Sensitive In Situ Prodrug Activation

Bo Wang, Sheng Zhang, Zi‐Tao Shen, Ting Hou, Yi‐Han Zhao, Meng‐Sheng Huang, Jian Li, Huan Chen, Peng‐Hui Hu, Zi‐Jiang Luo, Shuai Yuan, Feng‐Min Wang, Wei Li, Chang Shu, Xing‐Hua Xia and Ya Ding

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202314025

Nano-sized mesoporous hydrogen-bonded organic frameworks for in situ enzyme immobilization

Wenping Li, Jiafu Shi, Yu Chen, Xinyue Liu, Xiangxuan Meng, Zheyuan Guo, Shihao Li, Boyu Zhang and Zhongyi Jiang

Chemical Engineering Journal, 2023, 468, 143609
DOI: 10.1016/j.cej.2023.143609

Advances in aldo-keto reductases immobilization for biocatalytic synthesis of chiral alcohols

Wen Zhang, Zi-Qing Shao, Zhi-Xiu Wang, Yuan-Fan Ye, Shu-Fang Li and Ya-Jun Wang

International Journal of Biological Macromolecules, 2024, 274, 133264
DOI: 10.1016/j.ijbiomac.2024.133264

MOF-based nanozymes: Rational design and biomedical applications

Rui Chen, Ying Bao, Rong Huang, Huan Liu, Yang Luo and Dinglin Zhang

Biomaterials, 2026, 333, 124201
DOI: 10.1016/j.biomaterials.2026.124201

Covalent Organic Framework Based Crosslinked Porous Microcapsules for Enzymatic Catalysis

Mengchu Feng, Ziru Niu, Chunyan Xing, Yehao Jin, Xiao Feng, Yuanyuan Zhang and Bo Wang

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202306621

Eu3+-Modified Covalent Organic Frameworks for the Detection of a Vinyl Chloride Monomer Exposure Biomarker

Yinsheng Liu, Mingyue Wang, Yingfei Hui, Jiaying Tian, Jiaxi Xu, Zongyan Lu, Zeyun Yang, Hao Guo and Wu Yang

ACS Sens., 2024, 9, 315
DOI: 10.1021/acssensors.3c02015

Transforming RNA-Based Gene Therapy with Innovative Nanocarriers for siRNA and miRNA Delivery

Jitendra Singh Chaudhary, Dilip Kumar Chanchal, Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain, Anubhav Dubey, Mahima Pandey and Shahbaz Khan

CGT, 2026, 26, 1
DOI: 10.2174/0115665232355294250330002630

Engineering covalent organic frameworks with defect for high-performance immunosensor

Tianci Zhou, Ying Deng, Yu Sun, Keqin Ying, Dongmei Zhang, Xiafei Hu, Jinlong Li and Genxi Li

Nano Research, 2026, 19, 94908061
DOI: 10.26599/NR.2025.94908061

MOFs/COFs-based hybrids for agricultural sensors: Current state of art and beyond

Xin Liu, Peidi Fan, Xiaoyu Su, Lei Cai, Cui Wu, Yong Qiu, Weijie Yu, Feng Xu, Jianfeng Ping, Ping Wang, Hao Wan and Yuxiang Pan

TrAC Trends in Analytical Chemistry, 2024, 172, 117603
DOI: 10.1016/j.trac.2024.117603

Enzyme‐Immobilized Metal‐Organic Frameworks: From Preparation to Application

Jia‐Jing Li, Li Yin, Zi‐Fan Wang, Yi‐Chen Jing, Zhuo‐Lin Jiang, Ya Ding and Huai‐Song Wang

Chemistry An Asian Journal, 2022, 17
DOI: 10.1002/asia.202200751

Enzyme Immobilization using Covalent Organic Frameworks: From Synthetic Strategy to COFs Functional Role

Xiying Fan, Shibo Zhai, Song Xue and Linjie Zhi

ACS Appl. Mater. Interfaces, 2024, 16, 40371
DOI: 10.1021/acsami.4c06556

Triple-Enzyme Mimetic Flexible-Interlaced Ferromagnetic Porous-Organic-Polymer for Self-Adaptive Antibacterial Cascade Therapy via Microenvironment-Reprogramming and Photosensitizer-Aggregation-Suppression

Dandan Xu, Sue Cao, Weiwei Bian, Xiaoming Shi, Dong Zhang, Baolong Zhou, Kun Li, Yan Jiang, Yijun Liu, Yuyu Wang, Junjie Li and Xinkai Han

ACS Appl. Polym. Mater., 2025, 7, 9617
DOI: 10.1021/acsapm.5c00977

Ionic Liquid‐Mediated Dynamic Polymerization for Facile Aqueous‐Phase Synthesis of Enzyme‐Covalent Organic Framework Biocatalysts

Rui Gao, Xiaoxue Kou, Linjing Tong, Zhi‐Wei Li, Yujian Shen, Rongwei He, Lihong Guo, Hao Wang, Xiaomin Ma, Siming Huang, Guosheng Chen and Gangfeng Ouyang

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202319876

Recent Advances in Crystalline Porous Materials for Antibacterial Applications

Peijie Wu, Luofei Wei, Rui Yao, Bingyu Liu, Shuai‐Liang Yang, Liang Qiao, Xiao Wang, Wei Gong, Yan Liu, Yong Cui and Jinqiao Dong

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.202401961

A detailed insight into the role of nanosized drug carriers for the management of diabetic wounds

Abhinab Goswami, Pratap Kalita, Bedanta Bhattacharjee, Sandhanam K and Partha Pratim Dutta

Journal of Drug Delivery Science and Technology, 2025, 105, 106688
DOI: 10.1016/j.jddst.2025.106688

Solvent-free synthesis of a sulfur-containing magnetic porous organic framework for high efficiency removal of mercury

Zhiyu Zhou, Jinnan Zhang, Juan Yang, Feng Chen and Lijin Huang

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2026, 729, 138839
DOI: 10.1016/j.colsurfa.2025.138839

Covalent Organic Framework Based Crosslinked Porous Microcapsules for Enzymatic Catalysis

Mengchu Feng, Ziru Niu, Chunyan Xing, Yehao Jin, Xiao Feng, Yuanyuan Zhang and Bo Wang

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202306621

Exploring of laccase-like nanozyme and membrane filters for efficient removal of tetracycline hydrochloride

Yun Wang, Dan Wang, Qixuan Mu, Yanke Zhai, Jun Hai, Yibing Ji and Ruijun Li

Chemical Engineering Journal, 2024, 502, 158021
DOI: 10.1016/j.cej.2024.158021

Ionic organic cage as a versatile platform for immobilizing chemical and enzymatic sites for chemoenzymatic catalysis

Ke Zhao, Liang-Xiao Tan, Ning Gao and Jian-Ke Sun

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-60292-5

Integration of Multiple Enzymes Within Hydrogen‐Bonded Organic Frameworks for Efficient Cascade Photocatalytic CO2‐to‐Methanol Conversion in Water

Jiakang Tang, Yifei Lei, Qingxuan Tang, Shixing Lei, Qiao‐Yan Qi, Zhan‐Ting Li and Jia Tian

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202516599

Recent advances in analytical sensing detection of heavy metal ions based on covalent organic frameworks nanocomposites

Libo Li, Xiaoya Bi, Meiyang Zhen, Yue Ren, Li Zhang and Tianyan You

TrAC Trends in Analytical Chemistry, 2024, 171, 117488
DOI: 10.1016/j.trac.2023.117488

A Structural Mimic of Carbonic Anhydrase in Zeolitic Imidazolate Frameworks via Trans-functionalization for Enhancing Hydrolytic Activity

Fanchen Meng, Cheng Xu, Linghai Zhang, Xiaohan Huang, Xinglong Zhang, Wenlei Zhang, Yongqi Luo, Weina Zhang, Wei Huang, Fengwei Huo and Suoying Zhang

Research, 2024, 7
DOI: 10.34133/research.0434

MOFs and CRISPR: A powerful duo for biosensing nucleic acid and proteins

Snehlata Kujur, Sneha Kumari Binha and Dinesh Prasad

Microchemical Journal, 2025, 219, 116143
DOI: 10.1016/j.microc.2025.116143

Robust Nanozyme capsule-based PEC sensor for sensitive catechol analysis across broad pH and temperature ranges

Lianxi Pu, Yuanhao Liu, Hanyang Jiao, Tianshuo Wang, Shiling Wang, Dandan Huang, Jiahao Zhang, Zhenzhou Liu, Lijun Ding and Kun Wang

Microchemical Journal, 2026, 225, 118220
DOI: 10.1016/j.microc.2026.118220

Harnessing Self-Repairing and Crystallization Processes for Effective Enzyme Encapsulation in Covalent Organic Frameworks

Yufeng Zhang, Chunyan Xing, Zhenjie Mu, Ziru Niu, Xiao Feng, Yuanyuan Zhang and Bo Wang

J. Am. Chem. Soc., 2023, 145, 13469
DOI: 10.1021/jacs.3c04183

Leveraging histidine-nickel coordination for stable enzyme immobilization on metal-organic frameworks

Chenyang Huang, Wanning Gao, Mengting Chang, Xing Zhang, Junhua Tao, Yamei Lin and Lei Lin

Biochemical Engineering Journal, 2026, 227, 110050
DOI: 10.1016/j.bej.2025.110050

Efficient enzyme immobilization in hydrophilic cavities of porous aromatic frameworks for ester hydrolysis and kinetic resolution

Yuhui Zhai, Hengtao Lei, Zhaofu Zhang, Tingting Ma, He Xu, Hongxia Zhang, Yuyang Tian and XiaoYu Cao

Materials Today Chemistry, 2026, 53, 103485
DOI: 10.1016/j.mtchem.2026.103485

Reticular Synthesis of Highly Crystalline Three-Dimensional Mesoporous Covalent–Organic Frameworks for Lipase Inclusion

Haoyu Liu, Yi Zhou, Jinbiao Guo, Rui Feng, Gaoli Hu, Jiandong Pang, Yao Chen, Osamu Terasaki and Xian-He Bu

J. Am. Chem. Soc., 2023, 145, 23227
DOI: 10.1021/jacs.3c07904

A strategy to prepare robust enzyme@covalent organic framework microcapsules: a new platform for biosensing

Ying Ding, Jianming Liu, Longsheng Pei, Yuan Li, Yaqin Duan, Yonghai Song, Longfei Miao, Limin Liu and Li Wang

Bioactive Materials, 2025, 52, 623
DOI: 10.1016/j.bioactmat.2025.06.026

Electro-enzyme coupling systems for selective reduction of CO2

Yuman Guo, Xueming Hong, Ziman Chen and Yongqin Lv

Journal of Energy Chemistry, 2023, 80, 140
DOI: 10.1016/j.jechem.2023.01.041

Enantioseparation Membranes: Research Status, Challenges, and Trends

Qingsong Cheng, Qian Ma, Hebing Pei, Simin He, Rui Wang, Ruibin Guo, Nijuan Liu and Zunli Mo

Small, 2023, 19
DOI: 10.1002/smll.202300376

Applications of covalent organic frameworks (COFs)-based sensors for food safety: Synthetic strategies, characteristics and current state-of-art

Yaru Li, Lu Zhao, Yunfeng Bai and Feng Feng

Food Chemistry, 2025, 469, 142495
DOI: 10.1016/j.foodchem.2024.142495

In Situ Enzyme Immobilization by Covalent Organic Frameworks

Clémence Sicard

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202213405

Building the future: the research frontiers and industrial prospects in framework chemistry

Kan Yue, San-Yuan Ding, Hao Lei, Xian-He Bu, Xiao-Ming Chen and Xuefeng Fu

Sci. Sin.-Chim, 2024, 54, 815
DOI: 10.1360/SSC-2024-0009

Enzyme-Immobilized Porous Crystals for Environmental Applications

Hao Wang, Xiaoxue Kou, Rui Gao, Siming Huang, Guosheng Chen and Gangfeng Ouyang

Environ. Sci. Technol., 2024, 58, 11869
DOI: 10.1021/acs.est.4c01273

Biomimetic multienzyme nanocomplex for efficient cascade reactions

Hao Yuan, Shuting Yi, Lufan Jia, Sicheng Chen, Ting Guo and Tao Meng

Chemical Engineering Journal, 2023, 454, 140276
DOI: 10.1016/j.cej.2022.140276

Triple-helix as a target converter for trace pesticide detection based on CRISPR/Cas12a-based ECL biosensor

Wen Li, Yan Li, Li-Dan Zhao, Ruo Yuan, Ying Zhuo and Xia Zhong

Sensors and Actuators B: Chemical, 2024, 409, 135599
DOI: 10.1016/j.snb.2024.135599

Site-Selective Functionalization of Outer Surface and Different Inner Spaces of Nanoscale Hierarchically Mesoporous MOFs for the Specific Detection of Cancer Cells

Yuxin Zhou, Jingwen Chen, Fan Xia, Ximeng Liu, Jian Yang and Jinlou Gu

ACS Appl. Nano Mater., 2024, 7, 18006
DOI: 10.1021/acsanm.4c03381

Recent advances on biomedical applications of zirconium-based Nanozymes: A review

Mostafa Ghafori-Gorab, Amir Kashtiaray, Mahdi Karimi, Hooman Aghamirza Moghim Aliabadi, Fatemeh Bakhtiyar, Faegheh Daraei Ghadikolaei, Maryam Mohajeri and Ali Maleki

Chemical Engineering Journal, 2025, 505, 159464
DOI: 10.1016/j.cej.2025.159464

Enhancing Enzyme Activity Using Hydrophilic Hollow Layered Double Hydroxides as Encapsulation Carriers

Wenting He, Yijia Gan, Xingyi Qi, Han Wang, Hanyue Song, Ping Su, Jiayi Song and Yi Yang

ACS Appl. Mater. Interfaces, 2023, 15, 34513
DOI: 10.1021/acsami.3c05237

Acoustomicrofluidic synthesis of ZIF-8/HRP metal–organic framework composites with enhanced enzymatic activity and stability

Emily Massahud, Heba Ahmed, Lizebona A. Ambattu, Amgad R. Rezk and Leslie Y. Yeo

Materials Today Chemistry, 2023, 33, 101694
DOI: 10.1016/j.mtchem.2023.101694

Recent Advances in Biomolecule‐Engineered Metal‐Organic Frameworks (Bio‐MOFs): From Design, Bioengineering, and Structural/functional Regulation to Biocatalytic Applications

Chenxi Du, Youyin Xu and Gang Wei

The Chemical Record, 2025, 25
DOI: 10.1002/tcr.202500001

Rationally Designed Ionic Covalent Organic Networks (iCONs) with Efficient Antimicrobial Activities

Atikur Hassan, Cevella Saritha, Vinod K. Rajana, Debabrata Mandal and Neeladri Das

ACS Macro Lett., 2023, 12, 376
DOI: 10.1021/acsmacrolett.2c00686

Phosphorescence Enzyme-Mimics for Time-Resolved Sensitive Diagnostics and Environment-Adaptive Specific Catalytic Therapeutics

Mingyue Cui, Lulu Qian, Menglin Wu, Peiling Dai, Xueke Pang, Wenxin Xu, Zhixia Feng, Qiang Zhao, Houyu Wang, Bin Song and Yao He

ACS Nano, 2023, 17, 21262
DOI: 10.1021/acsnano.3c05552

Reticular Chemistry: A Versatile Platform for Engineering Heterogenous Biocatalysts

Si Liu, Peiji Deng, Qianfan Chen, Qijun Sun, Yanhan Wang, Hongyu Shi and Kang Liang

Advanced Science, 2026, 13
DOI: 10.1002/advs.202519207

Ligand Screening for Enzyme Immobilization Enables Efficient Removal of Aflatoxin B1 in Continuous Flow System

Yujie Peng, Shenglong Mu and Jun Ge

Toxins, 2026, 18, 95
DOI: 10.3390/toxins18020095

Integrating Metal–Organic Framework Hybrid into Nucleic Acid–Based Hydrogel for Highly Selective Recognition and Sensitive Detection of Sarafloxacin

Hongtao Jiang, Shuo Qi, Xiaoze Dong, Beijun Ang, Yin Zhang and Zhouping Wang

Anal. Chem., 2025, 97, 10550
DOI: 10.1021/acs.analchem.4c05180

Enhancing Biocatalysis: Metal–Organic Frameworks as Multifunctional Enzyme Hosts

Fanrui Sha, Xiaoliang Wang, Kent O. Kirlikovali and Omar K. Farha

Acc. Chem. Res., 2024, 57, 3500
DOI: 10.1021/acs.accounts.4c00622

Advances in design and preparation of nanozymes and their applications for constructing higher sensitive lateral flow assays

Haiyin Li, Yue Peng, Xinda Huang, Rongyan Wan, Li Zhang, Xuan Wang, Lirong Han, Linsen Li, Chuanfeng Wang and Jianling Chen

Coordination Chemistry Reviews, 2024, 510, 215797
DOI: 10.1016/j.ccr.2024.215797

Solution‐Mediated Photoreversible Switch Between 2D and 3D Hydrogen‐Bonded Organic Frameworks

Xiao Liu, Yingxiang Ye, Xu He, Qingyu Niu and Zhiqiang Li

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202508976

Self‐Propelled, High‐Crystalline Hydrogen‐Bonded Enzymatic Framework Assembled by Bottom‐Up Strategy

Huangsheng Yang, Jiahui Fu, Wei Huang, Tong Wu, Siming Huang, Guosheng Chen and Gangfeng Ouyang

Small Structures, 2023, 4
DOI: 10.1002/sstr.202200346

In-situ synthesis of enzyme-encapsulated covalent organic framework capsules for ultrasensitive electrochemical detection of breast cancer exosomes

Minghui Wang, Cuifei Chen, Zhenyong Hu, Ying Deng, Tianci Zhou, Lai Zhang, Jie Yang and Genxi Li

Chemical Engineering Journal, 2025, 515, 163785
DOI: 10.1016/j.cej.2025.163785

Enzyme immobilization based on reticular framework materials: Strategy, food applications, and prospect

Xiaorong Liu, Manyan Qiu, Yiyi Zhang, Junyu Pan, Wei Zhang, Ling Guo, Xianlong Zhang and Yujun Jiang

Advances in Colloid and Interface Science, 2025, 344, 103589
DOI: 10.1016/j.cis.2025.103589

Robust Immobilization and Activity Preservation of Enzymes in Porous Frameworks by Silica‐Based “Inorganic Glue”

Guansheng Zheng, Zhuang Zhou, Junxian Yang, Liang Zhou, Orysia Zaremba, Stefan Wuttke and Wei Zhu

Advanced Materials, 2026, 38
DOI: 10.1002/adma.202407831

Improving Both Stability and Sensitivity of Immunosensor by Spatially Controlled Enzyme‐Engineered Covalent Organic Frameworks

Xu Yan, Congtian Wei, Changshun Su, Xiaomin Liu, Peng Sun, Zhenlin Xu, Geyu Lu, Yuehe Lin and Hongxia Li

Adv Funct Materials, 2025, 35
DOI: 10.1002/adfm.202420159

Enzyme immobilization on covalent organic framework supports

Qianqian Zhu, Yunlong Zheng, Zhenjie Zhang and Yao Chen

Nat Protoc, 2023, 18, 3080
DOI: 10.1038/s41596-023-00868-x

Green synthesis of stable hybrid biocatalyst using a hydrogen-bonded, π-π-stacking supramolecular assembly for electrochemical immunosensor

Wei Huang, Haitao Yuan, Huangsheng Yang, Xiaomin Ma, Shuyao Huang, Hongjie Zhang, Siming Huang, Guosheng Chen and Gangfeng Ouyang

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-39364-x

Coordination Polymer Packaging Approach for Simplifying the Isolation and Recovery of Dissolved Organic Matter from Water

Junlang Qiu, Yangjian Zhou, Chunhua Feng, Guosheng Chen and Xin Yang

Environ. Sci. Technol., 2025, 59, 8244
DOI: 10.1021/acs.est.4c11047

Charge‐Assisted Hydrogen‐Bonded Organic Frameworks: From Crystal Engineering to Multifunctional Materials

Xian‐Xian Xiao, Kai Zheng, Hao‐Ran Yu, Fang‐Di Dong, Ding‐Yi Hu and Rui‐Biao Lin

Chemistry Methods, 2025, 5
DOI: 10.1002/cmtd.202400082

Cold to Hot: Tumor Immunotherapy by Promoting Vascular Normalization Based on PDGFB Nanocomposites

Shouzheng Ma, Zhimin Tian, Lei Liu, Jun Zhu, Jing Wang, Shoujie Zhao, Yejing Zhu, Jianfei Zhu, Wenchen Wang, Runmin Jiang, Yongquan Qu, Jie Lei, Junlong Zhao and Tao Jiang

Small, 2024, 20
DOI: 10.1002/smll.202308638

Open-Architecture Monolayered Metal–Organic Framework for Seamless Enzyme Integration in Photoenzymatic Catalysis

Yufeng Zhang, Kun Wang, Jiayu Wu, An Li, Hang Yu, Zhaobo Lyu, Zi Yang, Senhai Zeng, Xin Zhou, Jun Liu, Xiong Zhou, Ya-Wen Zhang and Guangxu Lan

J. Am. Chem. Soc., 2026, 148, 9049
DOI: 10.1021/jacs.5c22717

Hydrogen-bonded organic framework for regulating pathogenic autoantigen and oxidative stress in psoriasis treatment

Yuhang Li, Hui Yuan, Yi-Lun Cheng, Qiu-Xia Li, Rong Cao, Jin-Lin Li, Qi Yin, Can-Zhong Lu and Tian-Fu Liu

National Science Review, 2025, 12
DOI: 10.1093/nsr/nwaf132

Interface‐Adaptive Dual‐Color Hydrogel with Self‐Repairing Function and High Adhesion as Flexible Wearable Sensor for Minimally‐Invasive Monitoring Pesticide Residue in Living Crop

Jianling Chen, Zihan Zhu, Yafei Li, Zizhe Wang, Wendong Wang, Hong Chen, Xuelian Xin, Zhenguo Chi and Haiyin Li

Advanced Science, 2026, 13
DOI: 10.1002/advs.202512386

Unlocking of Hidden Mesopores for Enzyme Encapsulation by Dynamic Linkers in Stable Metal‐Organic Frameworks

Meng Qiao, Youcong Li, Yanqi Li, Mengting Chang, Xing Zhang and Shuai Yuan

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202409951

Enzymatic CO2 reduction catalyzed by natural and artificial Metalloenzymes

Yunling Deng, Jing-Xiang Wang, Barshali Ghosh and Yi Lu

Journal of Inorganic Biochemistry, 2024, 259, 112669
DOI: 10.1016/j.jinorgbio.2024.112669

Boosted Enzyme Activity via Encapsulation within Metal–Organic Frameworks with Pores Matching Enzyme Size and Shape

Ying Liu, Ziman Chen, Zheng Wang and Yongqin Lv

Advanced Science, 2024, 11
DOI: 10.1002/advs.202309243

Crystal Phase Transition-Driven Integration of Enzymes into 2D Metal–Organic Frameworks

Ningyi Zhong, Rongwei He, Wei Huang, Lihong Guo, Linjing Tong, Anlian Huang, Siming Huang, Janusz Pawliszyn, Guosheng Chen and Gangfeng Ouyang

ACS Appl. Mater. Interfaces, 2025, 17, 25733
DOI: 10.1021/acsami.5c04981

Highly ordered macroporous hydrogen-bonded organic frameworks based on small biocompatible molecules

Qiu-Xia Li, Wan-Zhen Cai, Xiao-Liang Ye, Yi Zeng, A. R. Mahammed Shaheer, Zai-Sheng Ye and Tian-Fu Liu

Nat Commun, 2025, 17
DOI: 10.1038/s41467-025-67123-7

An Artificial Compartmentalized Biocatalytic Cascade System Constructed With Enzyme‐Caged Reticulate Nanoporous Membranes

Wangsuk Oh, Dawoon Jeong and Ji‐Woong Park

Adv Materials Inter, 2023, 10
DOI: 10.1002/admi.202300185

Aldehyde Directed In Situ Loading of Ag Nanodots Around the Open Metal Sites of MOFs for the Tandem Catalysis of Nitrate to Ammonia

Yuting Zhang, Jiahao Ma, Biwen Wang, Anqi Lv, Qiuyu Zhang and Sifei Zhuo

Small, 2025, 21
DOI: 10.1002/smll.202408602

Ionic Liquid‐Mediated Dynamic Polymerization for Facile Aqueous‐Phase Synthesis of Enzyme‐Covalent Organic Framework Biocatalysts

Rui Gao, Xiaoxue Kou, Linjing Tong, Zhi‐Wei Li, Yujian Shen, Rongwei He, Lihong Guo, Hao Wang, Xiaomin Ma, Siming Huang, Guosheng Chen and Gangfeng Ouyang

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202319876

Vapor‐Assisted Mechanochemical Synthesis of Enzyme and Hydrogen‐Bonded Organic Framework Biocomposites

Michael R. Hafner, Natalija Pantalon Juraj, Kate Flint, Helmar Wiltsche, Heimo Wolinski, Heinz Amenitsch, Christian J. Doonan, Krunoslav Užarević and Francesco Carraro

Small, 2025, 21
DOI: 10.1002/smll.202504744

Selective Removal of Denatured Proteins Using MOF Nanopores

Hirotaka Taketomi, Nobuhiko Hosono and Takashi Uemura

J. Am. Chem. Soc., 2024, 146, 16369
DOI: 10.1021/jacs.4c03886

Biohybrid hydrogen-bonded organic framework sandwiched between nanoporous membranes: Novel structure for ultrasensitive electrochemical detection of urea

Lei Guo and Hongfang Zhang

Microchemical Journal, 2025, 209, 112897
DOI: 10.1016/j.microc.2025.112897

In Situ Gelled Covalent Organic Frameworks Electrolyte with Long-Range Interconnected Skeletons for Superior Ionic Conductivity

Chaoqun Niu, Shu Zhao and Yuxi Xu

J. Am. Chem. Soc., 2024, 146, 3114
DOI: 10.1021/jacs.3c10312

In Situ Encapsulation of Cytochrome c within Covalent Organic Frames Using Deep Eutectic Solvents under Ambient Conditions

Liangwei Li, Xiaoling Wu, Yuxia Pang, Hongming Lou and Zhixian Li

ACS Appl. Mater. Interfaces, 2023, 15, 53871
DOI: 10.1021/acsami.3c14479

Site-specific surface amination strategy facilitates biomimetic encapsulation of enzymes within hydrogen-bonded organic framework

Haoquan Huang, Haiting Chen, Xinran Dong, Yanbin Xu, Anlian Huang, Qiaoyi Cen, Huairou Zhu, Guosheng Chen, Wei Yi, Siming Huang and Gangfeng Ouyang

Chinese Chemical Letters, 2025, 36, 111223
DOI: 10.1016/j.cclet.2025.111223

Ferrocene-Modified Nanoscale Covalent Organic Frameworks for Ferroptosis-Based Sonodynamic Therapy Inhibit Breast Cancer and Its Bone Metastasis

Ming Wu, Yiqing Zeng, JianGang Chen, Zhen Yang, Siyuan Song, Rongkai Yan, Taofik Al Hassan and Yan Zhang

Cyborg Bionic Syst, 2026, 7
DOI: 10.34133/cbsystems.0490

A colorimetric and surface-enhanced Raman scattering dual-mode “sandwich” immunosensor for ultrasensitive detection of Salmonella

Sijia Hu, Tao Huang, Fulai Li, Yihui Yang, Hong Duan and Shengnan Zhan

Talanta, 2025, 295, 128248
DOI: 10.1016/j.talanta.2025.128248

Biocatalytic nanomotor-assisted ultrafiltration membrane system for selective removal and transformation of phenolic contaminants

Shu Xu, Zimou Feng, Linyun Bao, Zhiyang Zhu, Shenyang Wu, Yi Yang and Xinglin Lu

Matter, 2025, 8, 102216
DOI: 10.1016/j.matt.2025.102216

Monodispersed covalent organic framework nanocrystals in aqueous solution for DNA inclusion

Xinheng Lyu, Lezhi Yi, Liang Zhang, Jin Liu and Hexiang Deng

Sci. China Chem., 2023, 66, 3161
DOI: 10.1007/s11426-023-1674-7

Metal–organic framework-engineered enzyme/nanozyme composites: Preparation, functionality, and sensing mechanisms

Yujie Li, Huining Chai, Zhishuang Yuan, Chaonan Huang, Shasha Wang, Yingjie Sun, Xueji Zhang and Guangyao Zhang

Chemical Engineering Journal, 2024, 496, 153884
DOI: 10.1016/j.cej.2024.153884

Preserving High Porosity of Covalent Organic Frameworks via Functional Polymer Guest Introduction

Tianwei Xue, Olga A. Syzgantseva, Li Peng, Ruiqing Li, Yuyu Guo, Chengbin Liu, Tongxin Qiao, Wenli Hao, Jiaran Li, Lilin Zhu, Shuliang Yang, Jun Li and Wendy L. Queen

J. Am. Chem. Soc., 2024, 146, 35098
DOI: 10.1021/jacs.4c10273

Core‐Shell Reactor Partitioning Enzyme and Prodrug by ZIF‐8 for NADPH‐Sensitive In Situ Prodrug Activation

Bo Wang, Sheng Zhang, Zi‐Tao Shen, Ting Hou, Yi‐Han Zhao, Meng‐Sheng Huang, Jian Li, Huan Chen, Peng‐Hui Hu, Zi‐Jiang Luo, Shuai Yuan, Feng‐Min Wang, Wei Li, Chang Shu, Xing‐Hua Xia and Ya Ding

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202314025

Spatial Localization of Two Enzymes at Pickering Emulsion Droplet Interfaces for Cascade Reactions

Ke Li, Houbing Zou, Rammile Ettelaie, Jingxia Zhang and Hengquan Yang

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202300794

Dual Stimulus-Responsive Enzyme@Metal–Organic Framework-Polymer Composites toward Enhanced Catalytic Performance for Visual Detection of Glucose

Muhammad Ali Tajwar and Li Qi

ACS Appl. Bio Mater., 2024, 7, 325
DOI: 10.1021/acsabm.3c00918

Coordination bond regulation in metal–organic framework composites: From precise synthesis to advanced catalysis and emerging adsorption/purification applications

Wenkai Yu, Aoyun Li, Zhanchuang Lu, Hui Jiang, Yang Jiang, Haiyong Ni, Yuhua Wang and Lei Chen

Separation and Purification Technology, 2026, 387, 136625
DOI: 10.1016/j.seppur.2025.136625

Highly Enantioselective Catalysis by Enzyme Encapsulated in Metal Azolate Frameworks with Micelle-Controlled Pore Sizes

Hao Ren, Jian Yuan, Yi-Ming Li, Wen-Jing Li, Yi-Hang Guo, Yi-Bo Zhang, Bing-Hao Wang, Kaili Ma, Lu Peng, Guping Hu, Wen-Qi Wang, Hailong He, Lien-Yang Chou, Ming-Hua Zeng, Yue-Biao Zhang and Lin Cheng

ACS Cent. Sci., 2024, 10, 358
DOI: 10.1021/acscentsci.3c01432

A Portable Electrochemical Biosensor Based on an Amino-Modified Ionic Metal–Organic Framework for the One-Site Detection of Multiple Organophosphorus Pesticides

Qi Wu, Yifei Wang, Linxia Wang, Yu Su, Guorong He, Xiaojiang Chen, Lei Hou, Wenyan Zhang and Yao-Yu Wang

ACS Appl. Mater. Interfaces, 2024
DOI: 10.1021/acsami.4c13087

In Situ Enzyme Immobilization by Covalent Organic Frameworks

Clémence Sicard

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202213405

Construction of hierarchically porous covalent organic frameworks with enhanced enzyme accessibility for sensitive dopamine detection

Chao Zhong, Yuandi Xue, Shaofeng Dong, Cong Hu and Zian Lin

Talanta, 2025, 287, 127645
DOI: 10.1016/j.talanta.2025.127645

Photonanozyme with Light Mediated Activity

Zeyu Gong, Linjing Tong, Junhui Wang, Siming Huang, Guosheng Chen and Gangfeng Ouyang

ChemPlusChem, 2023, 88
DOI: 10.1002/cplu.202300352