Fluorescent probes for ferroptosis bioimaging: advances, challenges, and prospects

Junling Yin, Jingting Zhan, Qingxia Hu, Shuhong Huang and Weiying Lin

Chem. Soc. Rev., 2023, 52, 2011
DOI: 10.1039/D2CS00454B

Fluorescent probes for formaldehyde based on formaldehyde-promoted C–N cleavage of azanyl carbamates

Wanjin Xing, Yang Li, Yulin Que, Huan Xu, Wei Wang and Kaiyan Lou

Org. Biomol. Chem., 2024, 22, 7349
DOI: 10.1039/D4OB01198H

Recent advances in small-molecule fluorescent probes for studying ferroptosis

Ya-Lin Qi, Hai-Rong Wang, Li-Li Chen, Yong-Tao Duan, Sheng-Yu Yang and Hai-Liang Zhu

Chem. Soc. Rev., 2022, 51, 7752
DOI: 10.1039/D1CS01167G

An endoplasmic reticulum-targeting hydroxyl radical fluorescent probe for imaging of ferroptosis and screening of natural protectants

Hongyu Li, Xue Luo, Yue Jian, Jiajia Lv, Xinmin Li, Jie Gao, Wen Shi, Xiaohua Li, Zeli Yuan and Huimin Ma

Chem. Sci., 2025, 16, 4136
DOI: 10.1039/D4SC07953A

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Karandeep Grover, Alla Koblova, Aidan T. Pezacki, Christopher J. Chang and Elizabeth J. New

Chem. Rev., 2024, 124, 5846
DOI: 10.1021/acs.chemrev.3c00819

Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications

Tingting Meng, Danfeng He, Zhuolei Han, Rong Shi, Yuhan Wang, Bibo Ren, Cheng Zhang, Zhengwei Mao, Gaoxing Luo and Jun Deng

Nano-Micro Lett., 2024, 16
DOI: 10.1007/s40820-024-01455-9

Recent advances of luminescent sensors for iron and copper: Platforms, mechanisms, and bio-applications

Zhangping Li, Ji-Ting Hou, Shan Wang, Lei Zhu, Xiaojun He and Jianliang Shen

Coordination Chemistry Reviews, 2022, 469, 214695
DOI: 10.1016/j.ccr.2022.214695

A single mitochondria-targetable fluorescent probe for visualizing cysteine and glutathione in ferroptosis of myocardial ischemia/reperfusion injury

Jiayu Zeng, Minhui Liu, Ting Yang, Songjiao Li, Dan Cheng and Longwei He

Talanta, 2024, 270, 125610
DOI: 10.1016/j.talanta.2023.125610

Formaldehyde Promoted Tumor Cell Growth Through Reinforced Lactylation of Poly (ADP‐Ribose) Polymerase 1

Junfeng Wang and Huan Xu

J of Applied Toxicology, 2025, 45, 1285
DOI: 10.1002/jat.4773

Recent Advances of Fe(II) Fluorescence Probes Based on N-Oxide Structure

Hanyue Xiang, Shaoyin Wei, Yuji Wang and Nao Xiao

Chinese Journal of Organic Chemistry, 2025, 45, 1137
DOI: 10.6023/cjoc202407041

Photodynamic anticancer activity evaluation of novel 5-aminolevulinic acid and 3-hydroxypyridinone conjugates

Jingqi Zhang, Shengli Yuan, Miaoliang Fan, Keren Wang, Jianan Guo, Anjie Zang, Jinhui Ren, Weike Su, Changjun Zhang and Yuanyuan Xie

Bioorganic & Medicinal Chemistry, 2024, 105, 117726
DOI: 10.1016/j.bmc.2024.117726

Mitochondria-targeted fluorescent probes based on the FRET principle for the detection of sulfite

Zilong Gu, Xianteng Meng, Guoxing Hu, Chen Yang, Hui Yi, Changbin Gong, Wenge Yang and Yonghong Hu

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2026, 349, 127316
DOI: 10.1016/j.saa.2025.127316

Recent advances in organic small-molecule fluorescent probes for the detection of iron ions

Ning Duan, Jianxiong Hao, Dandan Zhao, Hongyu Tian and Shaoxiang Yang

Coordination Chemistry Reviews, 2026, 556, 217671
DOI: 10.1016/j.ccr.2026.217671

Recent Advances of Fluorescence Probes for Imaging of Ferroptosis Process

Hongyu Li, Yan An, Jie Gao, Mingyan Yang, Junjun Luo, Xinmin Li, Jiajia Lv, Xiaohua Li, Zeli Yuan and Huimin Ma

Chemosensors, 2022, 10, 233
DOI: 10.3390/chemosensors10060233

Versatile Switchable Targeted Polysiloxanes for High-Resolution Visualization of Mitochondrial and Lysosomal Interactions during Ferroptosis

Kun Zhang, Ying Lan, Fanfan Wang, Zhiming Gou, Mei Yan and Yujing Zuo

Anal. Chem., 2023, 95, 6303
DOI: 10.1021/acs.analchem.2c05137

Ferroptosis-driven metabolic reprogramming in macrophages: Reshaping glucose utilization landscapes

Yasheng Deng, Yafang Zheng, Qian Zhou, Taijin Lan and Qiu Chen

Chinese Medical Journal, 2026
DOI: 10.1097/CM9.0000000000004046

Fe2+ imaging in ferroptosis and drug-induced liver injury with a ratiometric near-infrared fluorescent probe

Shumin Feng, Junrong Zheng, Jinzheng Zhang, Zhisheng Gui and Guoqiang Feng

Sensors and Actuators B: Chemical, 2022, 371, 132512
DOI: 10.1016/j.snb.2022.132512

The Potential Role of Iron Homeostasis and Ferroptosis in Exercise Nutrition and Health

Qi Wang, Ruiyang Gao, Kongdi Zhu, Huilong Qiu, Jiaqiang Huang and Xia Zhang

Nutrients, 2026, 18, 139
DOI: 10.3390/nu18010139

Binding- and activity-based small molecule fluorescent probes for the detection of Cu+, Cu2+, Fe2+ and Fe3+ in biological systems

Yongqing Zhou, Xiaofeng Yang, Won Jun Jang, Mei Yan and Juyoung Yoon

Coordination Chemistry Reviews, 2025, 522, 216201
DOI: 10.1016/j.ccr.2024.216201

Accumulation of Intracellular Ferrous Iron in Inflammatory-Activated Macrophages

Huijuan Ma, Qi Shu, Dan Li, Tingqian Wang, Linyi Li, Xiaodong Song, Kaiyan Lou and Huan Xu

Biol Trace Elem Res, 2023, 201, 2303
DOI: 10.1007/s12011-022-03362-9

A NIR fluorescent probe for imaging labile iron(II) pools in ferroptosis-related disorders

Meirong Yi, Yuting Wang, Ruipeng Shen, Tao Ma, Jintao Zhao, Fei Han, Jirong Liu, Xinming Li, Baoxin Zhang and Jianguo Fang

Sensors and Actuators B: Chemical, 2026, 446, 138726
DOI: 10.1016/j.snb.2025.138726

Advances in ferroptosis: Synergistic therapies and fluorescent probes as arrows to target cancer's achilles heel

Baoshuai Wang, Longfang Ren, Mingli Li, Xi Zhang, Wei Hu, Fei Cheng, Luling Wu, Tony D. James and Taotao Qiang

Coordination Chemistry Reviews, 2025, 541, 216779
DOI: 10.1016/j.ccr.2025.216779

Ferroptosis Detection: From Approaches to Applications

Fantian Zeng, Sureya Nijiati, Longguang Tang, Jinmin Ye, Zijian Zhou and Xiaoyuan Chen

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202300379

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Tong-Mei Shi, Xiao-Fei Chen and Huihui Ti

J. Med. Chem., 2024, 67, 2238
DOI: 10.1021/acs.jmedchem.3c01749

Interaction between macrophages and ferroptosis: Metabolism, function, and diseases

Qiaoling Jiang, Rongjun Wan, Juan Jiang, Tiao Li, Yantong Li, Steven Yu, Bingrong Zhao and Yuanyuan Li

Chinese Medical Journal, 2025, 138, 509
DOI: 10.1097/CM9.0000000000003189

The impact of macrophage infiltration on [18F]FDG PET accuracy in identifying mediastinal and abdominal lymph node metastases: A retrospective cohort study

Jing Wei, Weijing Tao, Tianshuo Yang, Jie Dong and Carmelo Caldarella

PLoS One, 2026, 21, e0340327
DOI: 10.1371/journal.pone.0340327

Myricetin Alleviates Formaldehyde‐Exacerbated Inflammation in Asthmatic Mice Through Inhibition of Ferrous Iron Accumulation in Pulmonary Macrophages

Huijuan Ma, Peiyao Wang, Junfeng Wang and Huan Xu

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202501341

Iron homeostasis and ferroptosis in muscle diseases and disorders: mechanisms and therapeutic prospects

Qin Ru, Yusheng Li, Xi Zhang, Lin Chen, Yuxiang Wu, Junxia Min and Fudi Wang

Bone Res, 2025, 13
DOI: 10.1038/s41413-024-00398-6

Development of a NIR Iridium(III) Complex-Based Probe for the Selective Detection of Iron(II) Ions

Wanyi Wang, Zixi Zhang, Jingqi Liu, Lingtan Kong, Wanhe Wang, Chung-Hang Leung and Jing Wang

Biosensors, 2024, 14, 369
DOI: 10.3390/bios14080369

Ferroptosis Detection: From Approaches to Applications

Fantian Zeng, Sureya Nijiati, Longguang Tang, Jinmin Ye, Zijian Zhou and Xiaoyuan Chen

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202300379

Recent advance in the development of the fluorescent responsive probes for the study of ferroptosis

Baoli Dong, Shijing Li, Yan Wang, Xiaochan Tang, Ruifei Wang, Xiuqi Kong and Tao Yue

TrAC Trends in Analytical Chemistry, 2023, 168, 117327
DOI: 10.1016/j.trac.2023.117327