A new family of luminescent iridium complexes: synthesis, optical, and cytotoxic studies

Gonzalo Millán, Mattia Nieddu, Icíar P. López, Cintia Ezquerro, Jesús R. Berenguer, Ignacio M. Larráyoz, José G. Pichel and Elena Lalinde

Dalton Trans., 2023, 52, 6360
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Tuning the organelle specificity and cytotoxicity of iridium(iii) photosensitisers for enhanced phototheranostic applications

Jing-Hui Zhu, Guang-Xi Xu, Justin Shum, Lawrence Cho-Cheung Lee and Kenneth Kam-Wing Lo

Chem. Commun., 2021, 57, 12008
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Novel heterobimetallic Ir(iii)–Re(i) complexes: design, synthesis and antitumor mechanism investigation

Jun-Jian Lu, Xiu-Rong Ma, Kai Xie, Pei-Xin Yang, Rong-Tao Li and Rui-Rong Ye

Dalton Trans., 2022, 51, 7907
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Bioorthogonal dissociative rhenium(i) photosensitisers for controlled immunogenic cell death induction

Guang-Xi Xu, Lawrence Cho-Cheung Lee, Peter Kam-Keung Leung, Eunice Chiu-Lam Mak, Justin Shum, Kenneth Yin Zhang, Qiang Zhao and Kenneth Kam-Wing Lo

Chem. Sci., 2023, 14, 13508
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Bioorthogonally activated probes for precise fluorescence imaging

Youxin Fu, Xing Zhang, Luling Wu, Miaomiao Wu, Tony D. James and Run Zhang

Chem. Soc. Rev., 2025, 54, 201
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A Concerted Enzymatic and Bioorthogonal Approach for Extra‐ and Intracellular Activation of Environment‐Sensitive Ruthenium(II)‐Based Imaging Probes and Photosensitizers

Justin Shum, Lawrence Cho‐Cheung Lee, Michael Wai‐Lun Chiang, Yun‐Wah Lam and Kenneth Kam‐Wing Lo

Angew Chem Int Ed, 2023, 62
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Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

Lawrence Cho‐Cheung Lee and Kenneth Kam‐Wing Lo

Small Methods, 2024, 8
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A Concerted Enzymatic and Bioorthogonal Approach for Extra‐ and Intracellular Activation of Environment‐Sensitive Ruthenium(II)‐Based Imaging Probes and Photosensitizers

Justin Shum, Lawrence Cho‐Cheung Lee, Michael Wai‐Lun Chiang, Yun‐Wah Lam and Kenneth Kam‐Wing Lo

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202303931

Link to glow - iEDDA conjugation of a Ruthenium(II) tetrazine complex leading to dihydropyrazine and pyrazine complexes with improved 1O2 formation ability

Carolin Müller, Pascal Wintergerst, Shruthi Santhosh Nair, Nicolas Meitinger, Sven Rau and Benjamin Dietzek-Ivanšić

Journal of Photochemistry and Photobiology, 2022, 11, 100130
DOI: 10.1016/j.jpap.2022.100130

Bioorthogonal strategy-triggered In situ co-activation of aggregation-induced emission photosensitizers and chemotherapeutic prodrugs for boosting synergistic chemo-photodynamic-immunotherapy

Yu Teng, Dianyu Wang, Ziyu Yang, Ruxuan Wang, Shuyi Ning, Rongrong Zhang, Hong Yang, Xinchi Feng, Jianfeng Liu, Lijun Yang and Yulin Tian

Biomaterials, 2025, 317, 123092
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Toward Precise Antitumoral Photodynamic Therapy Using a Dual Receptor‐Mediated Bioorthogonal Activation Approach

Jacky C. H. Chu, Clarence T. T. Wong and Dennis K. P. Ng

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202214473

Organometallic d6, d8 and d10 metal complexes for biosensing and imaging, cancer therapy and theranosis

Yam-Yuet Lam, Nga-Sze Lee, Shun-Fung Lee and Clive Yik-Sham Chung

Journal of Organometallic Chemistry, 2024, 1005, 122982
DOI: 10.1016/j.jorganchem.2023.122982

Bioorthogonal Postlabeling Reveals Nuclear Localization of a Highly Cytotoxic Half‐Sandwich Ir(III) Tetrazine Complex in Live Cells

Alfonso Annunziata, Sadek Amhaz, Jérémy Forté, Geoffrey Gontard, Romain Morichon, Joëlle Sobczak‐Thépot and Michèle Salmain

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202500090

Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4

Madeline Denison, Justin J. Ahrens, Marilyn N. Dunbar, Habon Warmahaye, Aliza Majeed, Claudia Turro, Thomas A. Kocarek, Irina F. Sevrioukova and Jeremy J. Kodanko

Inorg. Chem., 2023, 62, 3305
DOI: 10.1021/acs.inorgchem.3c00059

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lawrence Cho-Cheung Lee and Kenneth Kam-Wing Lo

Chem. Rev., 2024, 124, 8825
DOI: 10.1021/acs.chemrev.3c00629

Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications

Lawrence Cho-Cheung Lee and Kenneth Kam-Wing Lo

J. Am. Chem. Soc., 2022, 144, 14420
DOI: 10.1021/jacs.2c03437

Supramolecular Materials and Strategies for Bioorthogonal Chemical Transformations

Annechien A. H. Laporte and Joost N. H. Reek

Chem. Rev., 2025, 125, 7223
DOI: 10.1021/acs.chemrev.5c00047

Syntheses, physicochemical characterizations, crystal structures and quantum-mechanical calculations of novel heteroleptic Cu(I) complexes with applications in dye-sensitized solar cells

Federico M.A. Tomás, María P. Zelaya, Natalia L. Calvo, Patricio A. Orrillo, Faustino E. Morán Vieyra, Martha Díaz Salazar, Analía Moreno, Mariana Tamasi, Daniel R. Vega, Néstor E. Katz and Florencia Fagalde

Inorganic Chemistry Communications, 2025, 182, 115650
DOI: 10.1016/j.inoche.2025.115650

Brightening New Horizons: Luminescent Transition Metal Complexes in Optical Imaging and Theranostic Applications

Lawrence Cho-Cheung Lee and Kenneth Kam-Wing Lo

ACS Cent. Sci., 2025, 11, 1289
DOI: 10.1021/acscentsci.5c00975

Phosphorogenic Iridium(III) bis‐Tetrazine Complexes for Bioorthogonal Peptide Stapling, Bioimaging, Photocytotoxic Applications, and the Construction of Nanosized Hydrogels

Alex Man‐Hei Yip, Calvin Kin‐Ho Lai, Ken Shek‐Man Yiu and Kenneth Kam‐Wing Lo

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202116078

Conditional Relay Activation of Theranostic Prodrug by Pretargeting Bioorthogonal Trigger and Fluorescence‐Guided Visible Light Irradiation

Shihong Li, Jing Pang, Yuanjun Sun, Yuchen Zhang and Ya‐Qiu Long

Angew Chem Int Ed, 2025, 64
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Controlled Dual Activation of Rhenium(I) Photosensitizers and Profluorophores/Prodrugs via a Dissociative Bioorthogonal Tetrazine–Isonitrile Reaction

Eunice Chiu‐Lam Mak, Lawrence Cho‐Cheung Lee and Kenneth Kam‐Wing Lo

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202516957

Conditional Relay Activation of Theranostic Prodrug by Pretargeting Bioorthogonal Trigger and Fluorescence‐Guided Visible Light Irradiation

Shihong Li, Jing Pang, Yuanjun Sun, Yuchen Zhang and Ya‐Qiu Long

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202422023

Phosphorescent Iridium(III) Phenanthrolinedione Complexes as Lifetime‐Responsive Bioorthogonal Probes for Wash‐Free Time‐Resolved Bioimaging of Cellular Labeling

Peiling Dai, Chenxiao Luo, Zhiqi Xu, Shuaishuai Sun, Yuyang Tian, Kenneth Yin Zhang, Kenneth Kam‐Wing Lo, Shujuan Liu, Wei Huang, Huan Wang and Qiang Zhao

Angew Chem Int Ed, 2025, 64
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Narrowband Pure Near‐Infrared (NIR) Ir(III) Complexes for Solution‐Processed Organic Light‐Emitting Diode (OLED) with External Quantum Efficiency Over 16 %

Xiaolong Yang, Shipan Xu, Yan Zhang, Chengyun Zhu, Linsong Cui, Guijiang Zhou, Zhao Chen and Yuanhui Sun

Angewandte Chemie, 2023, 135
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Bioorthogonal Chemistry in Cellular Organelles

Veronika Šlachtová, Marek Chovanec, Michal Rahm and Milan Vrabel

Top Curr Chem (Z), 2024, 382
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Controlled Dual Activation of Rhenium(I) Photosensitizers and Profluorophores/Prodrugs via a Dissociative Bioorthogonal Tetrazine–Isonitrile Reaction

Eunice Chiu‐Lam Mak, Lawrence Cho‐Cheung Lee and Kenneth Kam‐Wing Lo

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202516957

Leveraging the Aminothiol-Specific Phosphorogenic Response of Iridium(III) Thioester Complexes for the Development of Intracellular Sensors and Cancer Phototherapeutics

Eunice Chiu-Lam Mak, Ziyong Chen, Lawrence Cho-Cheung Lee, Liang-Liang Yan, Vivian Wing-Wah Yam and Kenneth Kam-Wing Lo

JACS Au, 2025, 5, 2825
DOI: 10.1021/jacsau.5c00413

High-definition and robust visualization of latent fingerprints utilizing ultrabright aggregation-induced emission of iridium developer

Ling Di, Yang Xing, Zhanxu Yang, Chun Li, Zongbao Yu, Xiaoning Wang and Zhengqiang Xia

Talanta, 2023, 264, 124775
DOI: 10.1016/j.talanta.2023.124775

Phosphorogenic Iridium(III) bis‐Tetrazine Complexes for Bioorthogonal Peptide Stapling, Bioimaging, Photocytotoxic Applications, and the Construction of Nanosized Hydrogels

Alex Man‐Hei Yip, Calvin Kin‐Ho Lai, Ken Shek‐Man Yiu and Kenneth Kam‐Wing Lo

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202116078

Phosphorescent Ir(III) Complexes for Biolabeling and Biosensing

Byung Hak Jhun, Dayoon Song, Soo Young Park and Youngmin You

Top Curr Chem (Z), 2022, 380
DOI: 10.1007/s41061-022-00389-3

Recent advances in developing bioorthogonally activatable photosensitizers for photodynamic therapy

Shuyi Ning, Yuanyuan Yao, Xinchi Feng and Yulin Tian

European Journal of Medicinal Chemistry, 2025, 291, 117672
DOI: 10.1016/j.ejmech.2025.117672

Engineered Bacteria Labeled with Iridium(III) Photosensitizers for Enhanced Photodynamic Immunotherapy of Solid Tumors

Wenkai Lin, Yu Liu, Jinhui Wang, Zhennan Zhao, Kai Lu, He Meng, Ruiqi Luoliu, Xiaojun He, Jianliang Shen, Zong‐Wan Mao and Wei Xia

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202310158

Narrowband Pure Near‐Infrared (NIR) Ir(III) Complexes for Solution‐Processed Organic Light‐Emitting Diode (OLED) with External Quantum Efficiency Over 16 %

Xiaolong Yang, Shipan Xu, Yan Zhang, Chengyun Zhu, Linsong Cui, Guijiang Zhou, Zhao Chen and Yuanhui Sun

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202309739

Engineered Bacteria Labeled with Iridium(III) Photosensitizers for Enhanced Photodynamic Immunotherapy of Solid Tumors

Wenkai Lin, Yu Liu, Jinhui Wang, Zhennan Zhao, Kai Lu, He Meng, Ruiqi Luoliu, Xiaojun He, Jianliang Shen, Zong‐Wan Mao and Wei Xia

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202310158

Phosphorescent Iridium(III) Phenanthrolinedione Complexes as Lifetime‐Responsive Bioorthogonal Probes for Wash‐Free Time‐Resolved Bioimaging of Cellular Labeling

Peiling Dai, Chenxiao Luo, Zhiqi Xu, Shuaishuai Sun, Yuyang Tian, Kenneth Yin Zhang, Kenneth Kam‐Wing Lo, Shujuan Liu, Wei Huang, Huan Wang and Qiang Zhao

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202504230

Toward Precise Antitumoral Photodynamic Therapy Using a Dual Receptor‐Mediated Bioorthogonal Activation Approach

Jacky C. H. Chu, Clarence T. T. Wong and Dennis K. P. Ng

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202214473

Tetrazine-Mediated Bioorthogonally Activated Therapeutic (TBAT) Platforms

Jungryun Kim, Snehasish Debnath, Eunji Kim, Changyu Yoon, Jiwoo Seo, Siwei Hua and Jong Seung Kim

J. Am. Chem. Soc., 2026, 148, 9169
DOI: 10.1021/jacs.5c23084