Emergency diagnosis made easy: matrix removal and analyte enrichment from raw saliva using paper-arrow mass spectrometry

Yufeng Zhou, Tung-Ting Sham, Cedric Boisdon, Barry L. Smith, Joanne C. Blair, Daniel B. Hawcutt and Simon Maher

Analyst, 2023, 148, 5366
DOI: 10.1039/D3AN00850A

Extraction and untargeted analysis of metabolome from undemineralised cortical bone matrix

Andrea Bonicelli, George Taylor and Noemi Procopio

Molecular Omics, 2024, 20, 517
DOI: 10.1039/D4MO00015C

Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line

Julia M. Malinowska, Taina Palosaari, Jukka Sund, Donatella Carpi, Ralf J. M. Weber, Gavin R. Lloyd, Maurice Whelan and Mark R. Viant

Arch Toxicol, 2023, 97, 721
DOI: 10.1007/s00204-022-03439-3

Olaris Global Panel (OGP): A Highly Accurate and Reproducible Triple Quadrupole Mass Spectrometry-Based Metabolomics Method for Clinical Biomarker Discovery

Masoumeh Dorrani, Jifang Zhao, Nihel Bekhti, Alessia Trimigno, Sangil Min, Jongwon Ha, Ahram Han, Elizabeth O’Day and Jurre J. Kamphorst

Metabolites, 2024, 14, 280
DOI: 10.3390/metabo14050280

Clinical advances in analytical profiling of signature lipids: implications for severe non-communicable and neurodegenerative diseases

Sutanu Sarkar, Deotima Roy, Bhaskar Chatterjee and Rajgourab Ghosh

Metabolomics, 2024, 20
DOI: 10.1007/s11306-024-02100-7

Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay

Elena Sostare, Tara J. Bowen, Thomas N. Lawson, Anne Freier, Xiaojing Li, Gavin R. Lloyd, Lukáš Najdekr, Andris Jankevics, Thomas Smith, Dorsa Varshavi, Christian Ludwig, John K. Colbourne, Ralf J. M. Weber, David M. Crizer, Scott S. Auerbach, John R. Bucher and Mark R. Viant

Chem. Res. Toxicol., 2024, 37, 923
DOI: 10.1021/acs.chemrestox.4c00002

Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research

Stanislava Rakusanova, Oliver Fiehn and Tomas Cajka

TrAC Trends in Analytical Chemistry, 2023, 158, 116825
DOI: 10.1016/j.trac.2022.116825

Lipid Profiling of Pacific Abalone (Haliotis discus hannai) at Different Developmental Stages Using Ultrahigh Performance Liquid Chromatography‐Tandem Mass Spectrometry

Hey Gene Lee, MinJoong Joo, Jong-Moon Park, Mi Ae Kim, JeongHun Mok, Seong-Hyeon Cho, Young Chang Sohn, Hookeun Lee and María José Trujillo-Rodríguez

Journal of Analytical Methods in Chemistry, 2022, 2022
DOI: 10.1155/2022/5822562

Optimization Strategies for Mass Spectrometry-Based Untargeted Metabolomics Analysis of Small Polar Molecules in Human Plasma

Michał Kaczmarek, Nanyun Zhang, Ludmila Buzhansky, Sharon Gilead and Ehud Gazit

Metabolites, 2023, 13, 923
DOI: 10.3390/metabo13080923

Scaling-up metabolomics: Current state and perspectives

Ghina Hajjar, Millena C. Barros Santos, Justine Bertrand-Michel, Cécile Canlet, Florence Castelli, Nicolas Creusot, Sylvain Dechaumet, Binta Diémé, Franck Giacomoni, Patrick Giraudeau, Yann Guitton, Etienne Thévenot, Marie Tremblay-Franco, Christophe Junot, Fabien Jourdan, François Fenaille, Blandine Comte, Pierre Pétriacq and Estelle Pujos-Guillot

TrAC Trends in Analytical Chemistry, 2023, 167, 117225
DOI: 10.1016/j.trac.2023.117225

Development and Application of an LC-MS/MS Untargeted Exposomics Method with a Separated Pooled Quality Control Strategy

Gianfranco Frigerio, Camilla Moruzzi, Rosa Mercadante, Emma L. Schymanski and Silvia Fustinoni

Molecules, 2022, 27, 2580
DOI: 10.3390/molecules27082580

Evaluation of Two Simultaneous Metabolomic and Proteomic Extraction Protocols Assessed by Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Ruba A. Zenati, Alexander D. Giddey, Hamza M. Al-Hroub, Yousra A. Hagyousif, Waseem El-Huneidi, Yasser Bustanji, Eman Abu-Gharbieh, Mohammad A. Y. Alqudah, Mohd Shara, Ahmad Y. Abuhelwa, Nelson C. Soares and Mohammad H. Semreen

IJMS, 2023, 24, 1354
DOI: 10.3390/ijms24021354

Analysis of Relationships between Metabolic Changes and Selected Nutrient Intake in Women Environmentally Exposed to Arsenic

Monika Sijko-Szpańska and Lucyna Kozłowska

Metabolites, 2024, 14, 75
DOI: 10.3390/metabo14010075

Tips and tricks for LC–MS-based metabolomics and lipidomics analysis

Stanislava Rakusanova and Tomas Cajka

TrAC Trends in Analytical Chemistry, 2024, 180, 117940
DOI: 10.1016/j.trac.2024.117940

Metabolomics in chemical risk analysis – A review

M. Hernández-Mesa, B. Le Bizec and G. Dervilly

Analytica Chimica Acta, 2021, 1154, 338298
DOI: 10.1016/j.aca.2021.338298

An Optimised Monophasic Faecal Extraction Method for LC-MS Analysis and Its Application in Gastrointestinal Disease

Patricia E. Kelly, H Jene Ng, Gillian Farrell, Shona McKirdy, Richard K. Russell, Richard Hansen, Zahra Rattray, Konstantinos Gerasimidis and Nicholas J. W. Rattray

Metabolites, 2022, 12, 1110
DOI: 10.3390/metabo12111110

Supplementation with willow containing condensed tannins shifted nitrogen excretion from urine to faeces in yearling ewes

J.P. Thompson, O. Cristobal-Carballo, T. Yan, W.E. Zeller, S. Huws, L. Safoi, A.D. Southam, C. Ludwig, G.R. Lloyd, S. Stergiadis and K. Theodoridou

animal, 2025, 19, 101698
DOI: 10.1016/j.animal.2025.101698

HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium

Lucyna Kozłowska, Tiina Santonen, Radu Corneliu Duca, Lode Godderis, Karolina Jagiello, Beata Janasik, An Van Nieuwenhuyse, Katrien Poels, Tomasz Puzyn, Paul T. J. Scheepers, Monika Sijko, Maria João Silva, Anita Sosnowska, Susana Viegas, Jelle Verdonck and Wojciech Wąsowicz

Metabolites, 2022, 12, 362
DOI: 10.3390/metabo12040362

Porous Silicon Particle-Assisted Mass Spectrometry Technology Unlocks Serum Metabolic Fingerprints in the Progression From Chronic Hepatitis B to Hepatocellular Carcinoma

Xinrong Jiang, Liye Tao, Shuo Cao, Zhengao Xu, Shuang Zheng, Huafang Zhang, Xinran Xu, Xuetong Qu, Xingyue Liu, Jiekai Yu, Xiaoming Chen, Jianmin Wu and Xiao Liang

ACS Appl. Mater. Interfaces, 2025, 17, 5893
DOI: 10.1021/acsami.4c17563

Metabolomics and Lipidomics for Studying Metabolic Syndrome: Insights into Cardiovascular Diseases, Type 1 & 2 Diabetes, and Metabolic Dysfunction-Associated Steatotic Liver Disease

S Rakusanova and T Cajka

Physiol Res, 2024, S165
DOI: 10.33549/physiolres.935443

Multiomics Approach Reveals Serum Biomarker Candidates for Congenital Zika Syndrome

Patricia Sosa-Acosta, Mauricio Quiñones-Vega, Jéssica de S. Guedes, Danielle Rocha, Letícia Guida, Zilton Vasconcelos, Fábio C. S. Nogueira and Gilberto B. Domont

J. Proteome Res., 2024, 23, 1200
DOI: 10.1021/acs.jproteome.3c00677

Saliva metabolome alterations after acute stress

Liat Morgan, Rune Isak Dupont Birkler, Shira Shaham-Niv, Yonghui Dong, Tal Wachsman, Lior Carmi, Boris Yakobson, Lihi Adler-Abramovich, Hagit Cohen, Joseph Zohar, Melissa Bateson and Ehud Gazit

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-23136-6

Assessment of Biphasic Extraction Methods of Mouse Fecal Metabolites for Liquid Chromatography–Mass Spectrometry-Based Metabolomic Studies

Shuting Yu, Jianxin Fan, Lin Zhang, Xuemei Qin and Zhenyu Li

J. Proteome Res., 2021, 20, 4487
DOI: 10.1021/acs.jproteome.1c00450

Untargeted metabolomic and lipidomic profiling in a hyperuricemic rabbit model: a pilot study

Junyoung Ahn, Bo Young Hwang, Kyo Bin Kang, Nak-Hoon Son, Hyang-Ja Lee, Jongwon Oh, Mi-Young Kim, Sanghoo Lee, Mikyeong Lee, Kyoung-Ryul Lee, Sung Kweon Cho and Jeong-Ho Kim

Analytical Biochemistry, 2026, 713, 116072
DOI: 10.1016/j.ab.2026.116072

Automated green sample preparation for quantitative extraction of lipids in different sample matrices

Pia Wittenhofer, Lidia Montero, Oliver J. Schmitz and Sven W. Meckelmann

Green Analytical Chemistry, 2024, 10, 100128
DOI: 10.1016/j.greeac.2024.100128

Characterization of Monophasic Solvent-Based Tissue Extractions for the Detection of Polar Metabolites and Lipids Applying Ultrahigh-Performance Liquid Chromatography–Mass Spectrometry Clinical Metabolic Phenotyping Assays

Andrew D. Southam, Harriet Pursell, Gianfranco Frigerio, Andris Jankevics, Ralf J. M. Weber and Warwick B. Dunn

J. Proteome Res., 2021, 20, 831
DOI: 10.1021/acs.jproteome.0c00660

Formic Acid Pretreatment Enhances Untargeted Serum and Plasma Metabolomics

Tereza Kacerova, Elisabete Pires, Abigail Dixon, Rachel Williams, Isabelle Legge, Mia Hippisley, Abi G. Yates, A. David Smith, Daniel C. Anthony, Fay Probert and James S. O. McCullagh

Anal. Chem., 2025, 97, 23014
DOI: 10.1021/acs.analchem.5c03725

Integrative Metabolomics and Proteomics Allow the Global Intracellular Characterization of Bacillus subtilis Cells and Spores

Yixuan Huang, Bhagyashree N. Swarge, Winfried Roseboom, Jurre D. Bleeker, Stanley Brul, Peter Setlow and Gertjan Kramer

J. Proteome Res., 2024, 23, 596
DOI: 10.1021/acs.jproteome.3c00386

Utilising a Clinical Metabolomics LC-MS Study to Determine the Integrity of Biological Samples for Statistical Modelling after Long Term −80 °C Storage: A TOFI_Asia Sub-Study

Aidan Joblin-Mills, Zhanxuan E. Wu, Ivana R. Sequeira-Bisson, Jennifer L. Miles-Chan, Sally D. Poppitt and Karl Fraser

Metabolites, 2024, 14, 313
DOI: 10.3390/metabo14060313

Biochemical Features and Clinical Factors Influencing Response to Surfactant Treatment Among Infants Born Late Preterm with Respiratory Distress Syndrome

Lucia Lanciotti, Anna Sartori, Manuela Simonato, Alessio Correani, Paola Cogo, Ilaria Burattini, Chiara Giorgetti, Roberta Centorrino, Barbara Loi, Daniele De Luca and Virgilio Carnielli

The Journal of Pediatrics, 2025, 284, 114644
DOI: 10.1016/j.jpeds.2025.114644

The Effects of Two Kinds of Dietary Interventions on Serum Metabolic Profiles in Haemodialysis Patients

Lucyna Kozlowska, Karolina Jagiello, Krzesimir Ciura, Anita Sosnowska, Rafal Zwiech, Zbigniew Zbrog, Wojciech Wasowicz and Jolanta Gromadzinska

Biomolecules, 2023, 13, 854
DOI: 10.3390/biom13050854

Current status and advances in untargeted LC-MS tissue lipidomics studies in cardiovascular health

Ana Carolina Alves dos Santos and Dajana Vuckovic

TrAC Trends in Analytical Chemistry, 2024, 170, 117419
DOI: 10.1016/j.trac.2023.117419

Multiscale workflow for the profiling and identification of urinary food bioactives metabolites Part I: Optimizing urine extraction

Evangelos Kalampokis, Theodora Nikou, Stavros Beteinakis and Maria Halabalaki

Analytica Chimica Acta, 2025, 1353, 343947
DOI: 10.1016/j.aca.2025.343947

Benchmarking One-Phase Lipid Extractions for Plasma Lipidomics

Marcus Höring, Christoph Stieglmeier, Katja Schnabel, Tucker Hallmark, Kim Ekroos, Ralph Burkhardt and Gerhard Liebisch

Anal. Chem., 2022, 94, 12292
DOI: 10.1021/acs.analchem.2c02117

Liquid chromatography–mass spectrometry–based metabolomics approaches for foodomics research

Tomas Cajka

Current Opinion in Food Science, 2024, 58, 101201
DOI: 10.1016/j.cofs.2024.101201

Unlocking the potential of willow condensed tannins: effects on rumen fermentation, microbiome, and metabolome for sustainable ruminant nutrition

Joshua P. Thompson, Omar Cristobal-Carballo, Tianhai Yan, Katie Lawther, Nicholas J. Dimonaco, Wayne E. Zeller, Zhenbin Zhang, Sharon Huws, Laudina Safo, Andrew D. Southam, Christian Ludwig, Gavin R. Lloyd, Sokratis Stergiadis and Katerina Theodoridou

anim microbiome, 2025, 7
DOI: 10.1186/s42523-025-00444-6

Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

Florence Anne Castelli, Giulio Rosati, Christian Moguet, Celia Fuentes, Jose Marrugo-Ramírez, Thibaud Lefebvre, Hervé Volland, Arben Merkoçi, Stéphanie Simon, François Fenaille and Christophe Junot

Anal Bioanal Chem, 2022, 414, 759
DOI: 10.1007/s00216-021-03586-z

A rapid single-phase extraction for polar staphylococcal lipids

Kingsley Bimpeh and Kelly M. Hines

Anal Bioanal Chem, 2023, 415, 4591
DOI: 10.1007/s00216-023-04758-9

Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics

Tara J. Bowen, Andrew D. Southam, Andrew R. Hall, Ralf J. M. Weber, Gavin R. Lloyd, Ruth Macdonald, Amanda Wilson, Amy Pointon and Mark R. Viant

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-40333-7

Metal-organic framework derived Mn0.2Zn0.8Se/C amalgamated with nitrogen-doped graphene hydrogel for antioxidant trolox detection in food, environmental, and biological samples

Akash Ashokrao Jagtap, Rajalakshmi Sakthivel, Subbiramaniyan Kubendhiran, Lu-Yin Lin, Sayee Kannan Ramaraj, Xinke Liu, Dhanaprabhu Pattappan, Hsu-Wei, Yi-Ting Lai, Ching-Wei Tung and Ren-Jei Chung

Chemical Engineering Journal, 2024, 496, 154178
DOI: 10.1016/j.cej.2024.154178

Urine metabolomics for seronegative rheumatoid arthritis: an exploratory dual-platform analysis

Koteswari Peddi, Satyanarayana Swamy Cheekatla, Usharajeswari Davulury, Prathyash Ushus M J, Satish Mutyam, Siva Kumar Kandula, Vishnu Vardhan Reddy Munagala and Sivakumar Vallabhapurapu

Molecular Omics, 2026, 22
DOI: 10.1093/momics/aaiaf004

Metabolic Changes and Their Associations with Selected Nutrients Intake in the Group of Workers Exposed to Arsenic

Monika Sijko, Beata Janasik, Wojciech Wąsowicz and Lucyna Kozłowska

Metabolites, 2023, 13, 70
DOI: 10.3390/metabo13010070

HBM4EU E-waste study – An untargeted metabolomics approach to characterize metabolic changes during E-waste recycling

Lucyna Kozlowska, Susana Viegas, Paul T.J. Scheepers, Radu C. Duca, Lode Godderis, Carla Martins, Krzesimir Ciura, Karolina Jagiello, Maria João Silva, Selma Mahiout, Inese Mārtiņsone, Linda Matisāne, An van Nieuwenhuyse, Tomasz Puzyn, Monika Sijko-Szpanska, Jelle Verdonck and Tiina Santonen

Environment International, 2025, 196, 109281
DOI: 10.1016/j.envint.2025.109281

Establishing Quality Control Metrics for Large-Scale Plasma Proteomic Sample Preparation

Nekesa C. Oliver, Min Ji Choi, Albert B. Arul, Marsalas D. Whitaker and Renã A. S. Robinson

ACS Meas. Sci. Au, 2024, 4, 442
DOI: 10.1021/acsmeasuresciau.3c00070

Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice

Mark R. Viant, E. Amstalden, T. Athersuch, M. Bouhifd, S. Camuzeaux, D. M. Crizer, P. Driemert, T. Ebbels, D. Ekman, B. Flick, V. Giri, M. Gómez-Romero, V. Haake, M. Herold, A. Kende, F. Lai, P. E. G. Leonards, P. P. Lim, G. R. Lloyd, J. Mosley, C. Namini, J. R. Rice, S. Romano, C. Sands, M. J. Smith, T. Sobanski, A. D. Southam, L. Swindale, B. van Ravenzwaay, T. Walk, R. J. M. Weber, F. M. Zickgraf and H. Kamp

Arch Toxicol, 2024, 98, 1111
DOI: 10.1007/s00204-024-03680-y

Mass spectrometry-based characterisation of the cardiac microtissue metabolome and lipidome

Tara J. Bowen, Andrew R. Hall, Andrew D. Southam, Ossama Edbali, Ralf J. M. Weber, Amanda Wilson, Amy Pointon and Mark R. Viant

Metabolomics, 2025, 21
DOI: 10.1007/s11306-025-02252-0